IVF Treatment And Fertility
Every woman wants to feel the maternity. We try to see smiling on your face for that very small breath to be included into your world. We, as Huma IVF Center, plan to be with you in this process from the first step of your treatment to your birth with awareness of your infertility problems. We target to bring you together with the healthy individuals in your home while starting with the slogan ‘Let us Add Your Imagination into Your Life’, believe that you will feel safe and in peace in our center. We take the fair pride in presenting the high quality service to you with a principle trying to catch the world standards with our knowledge.
WHY IS HUMA IVF CENTER?
Our success in the assisted reproductive treatments is based on a team working in plan and in coordination.
Our team consisted of the gynaecologists, embryologists, nurses and the patient consultants expert at their subjects, open to share information shall be glad to give service to you in this way where you started in order to be able to have a child.
Huma IVF Center started out by making renewing itself every passing day in the infertility practices a rule. We are over the world standards at rates of pregnancy to be obtained by using the assisted reproductive techniques.
Our patient consultants are in your service in all stages of your treatments in order to ease the IVF center treatment processes of our patients who will come to our center for treatment from abroad. We enable accommodation at a discount in our contractual hotels and the transportation support, prepare the programs where you will be able to follow your treatment at a distance.
IVF Center Treatment Techniques
• TESE- TESA Practices
• PGT (Pre-implantation Genetic Diagnostic)
• Calcium Ionophore
• Intra lipid
• Asisted Hatching
• Microchip
• Embryoscopy
• Pool Method
• Uterus Resting
• PRP
Ear, Nose, Throat
Ear Nose Throat
In our Ear Nose and Throat Polyclinic, ear diseases such as ear infections, hearing loss, balance disorders and tinnitus, nasal congestion, nasal discharge, olfactory disorders, sinusitis, nasal diseases such as allergic rhinitis, throat diseases such as pharyngitis, tonsillitis, other rare diseases of the mouth and throat ; In addition to hoarseness, dysphagia and speech disorders, cancer diagnosis and treatment of the neck are performed. Our ENT polyclinic is equipped with devices and equipment that allow endoscopic examinations in addition to classical examination tools.
Nose Aesthetics (Rhinoplasty)
Rhinoplasty is an aesthetic operation performed to correct or reconstruct the appearance of the nose. Apart from visual purposes, rhinoplasty is also performed to eliminate structural defects that cause breathing problems. It is also a frequently performed surgery in the treatment of nasal fractures.
The size of the nose, shape and angle of the nose can be changed with Rhinoplasty (nose aesthetics), which is the most preferred operation among aesthetic surgeries and is performed to create a beautiful nose that is compatible with the face and liked by the person himself and his surroundings.
In which cases is rhinoplasty necessary?
• If the patient has aesthetic concerns
• If there are breathing problems due to various functional disorders
• In sinus problems
• In nasal fractures
• In case of cleft lip (with other operations)
• In severe facial burns
How Is Rhinoplasty Performed?
With the first examination to be performed by the surgeon, the patient's complaints, the desired visual changes and whether they are suitable for the nose or face structure are evaluated by sharing ideas between the doctor and the patient. With a detailed examination, it can be determined whether there is any problem in the nose that may prevent the rhinoplasty operation. In the absence of a structural problem, general health checks should also be carried out, and the presence of conditions that may interfere with the surgical operation, such as bleeding diseases, should be investigated. It is very important for the doctor and the patient to establish a good communication with the patient in terms of the shape changes to be made in the patients who are determined to be suitable for the operation, and to explain the patient's expectations to the doctor in a good way. The planning phase is completed by taking photographs of the nose from various angles.
When the day of the operation comes, general anesthesia is usually applied depending on the type of surgery. The duration of the operation also varies according to the procedures to be performed. On average, a rhinoplasty operation is expected to take approximately 1.5-2 hours. After the operation, which is performed by choosing the most suitable method for the patient, open or closed methods, the patients are discharged after being kept under observation for a certain period of time.
How long does the recovery process take in rhinoplasty?
After the rhinoplasty operation, it is of great importance to preserve the shape of the nose and the operation area in order to be successful in the treatment applications performed on the nose. Therefore, any trauma that will adversely affect the shape of the nose should be avoided. Apart from trauma, it is extremely important not to use heavy glasses, not to lie on your side or to apply pressure to the nose area for a period of time. After the surgery, resting adequately, especially for the first two or three days, and avoiding strenuous activities for a week will accelerate the healing process. In addition, medications prescribed by the physician should be used regularly. The control examinations given should not be interrupted, and if there is a dressing suggestion, they should be done regularly.
Today, rhinoplasty surgery gives extremely successful results thanks to the advanced techniques applied. Success in rhinoplasty means a nose that is both visually pleasing to the patient and performing its functions in a healthy way.
Who is suitable for Eyelid Aesthetics (Blepharoplasty)?
Eyelid aesthetics are mostly performed by individuals over the age of 35. It is possible for anyone with a medical need to have it done at any age. One of the first structures to show aging on the human face is the upper eyelid. Eyelid aesthetics (blepharoplasty) surgery cannot stop the ongoing aging of the eyelids; but the tired appearance on the face can be stopped for about 10 years.
How is upper eyelid aesthetics performed?
Upper eyelid aesthetics (blepharoplasty) or droopy eyelid surgery is the process of removing excess skin and fat tissue from the area due to the loss of tension in the skin. The surgical scar does not attract much attention as it will remain on the upper eyelid and will be open during the day. However, in order to avoid the scar, an incision is made from the eyelid fold line and aesthetic stitches are applied. Of course, this deformation of the skin does not occur only on the eyelid, so it gives better cosmetic results when applied together with forehead lift and eyebrow lifting operations.
In addition, interventions such as almond eye aesthetics along with upper eyelid aesthetics (blepharoplasty) are frequently preferred by patients.
How is lower eyelid aesthetics performed?
The fat pads located on the cheekbones atrophy (weak) with the effect of gravity along with the aging process. This causes signs of aging in the form of slumping or edema under the lower eyelid and prominent smile lines around the mouth. The lower eyelid should be evaluated by your physician and checked for bagging and sagging. The form of treatment should be evaluated. If surgery is required, the specialist physician should initiate the planning and process. In lower eyelid aesthetics, the surgical incision is made just below the eyelashes. The skin is lifted and the fat packets are removed. If the under-eye sunkenness continues after the surgery, an under-eye fat injection may be required after recovery.
How long does it take for Eyelid Aesthetics (Blepharoplasty) surgery and post-operative recovery?
After Eyelid Aesthetic Surgery, patients do not have serious pain. Movement is allowed, provided that it is nourished and not heavy. The patient, who is discharged on the same day, is evaluated again the next day and 5 days later. Stitches are often dissolving stitches. However, when necessary, the stitches are removed painlessly without waiting for them to dissolve. After the 5th day, it is allowed to shower and return to normal life. In order to reduce scars in Eyelid Aesthetics, scar reducing creams are sometimes recommended to patients.
PGD (Pre-implantation Genetic Diagnostic)
PREIMPLANTATION GENETIC DIAGNOSIS
In recent years, developments in genetics allow genetic analysis to be carried out on embryos developed in vitro by in vitro fertilization ethods and the placement of selected healthy embryos in the uterus of the mother before pregnancy occurs. This method is called pre- regnancy genetic diagnosis (Preimplantation Genetic Diagnosis-PGD).
One of the most important application areas of the PGT technique embryos that do not have a genetic disease but may not have a genetic disorder in their chromosomes.
These disorders are more common in women of advanced age (35 years and older). This situation may result in infertility as it both reduces the chance of attachment of the embryo (implantation) and may cause unwanted abortions. As a matter of fact, 40 out of every 100 pregnancies in women aged 39 and over have problems that occur due to a numerical chromosomal disorder
The aim of PGD is to increase implantation rates, reduce spontaneous abortions and increase healthy baby birth rates by selecting hromosomally normal embryos. Indeed, the miscarriage rate, which can reach up to 23 percent in normal pregnancy due to chromosomal disorders, may decrease to 9 percent after PGD.
Pre-pregnancy genetic diagnosis is performed by taking 1 or 2 cells from embryos developed as a result of fertilization of egg and sperm cells obtained from mother and father candidates in laboratory environment. Special methods called Fluorescence In Situ Hybridization (FISH), Microarray-based comparative genomic hybridization (aCGH) or Polymerase Chain Reaction (PCR) are used for genetic diagnosis. Diagnosis of numerical chromosomal disorders such as monosomy or trisomy (Down syndrome and other trisomies) and single gene diseases (such as hemophilia, Mediterranean anemia, cystic fibrosis, muscular dystrophies) in the baby to be born is possible with PGD. Thus, healthy babies are born by transferring disease-free, healthy embryos to the expectant mother.
DIAGNOSIS BEFORE PREGNANCY
- In couples with a genetic or hereditary disease carrier,
- In couples who have a child or children with a previous genetic disease,
- For the purpose of HLA genotyping (tissue typing),
- In the identification of diseases showing genetic predisposition (tendency)
- Women in the advanced age group (37 years and over) who have been accepted for assisted reproductive techniques,
- In couples with recurrent early pregnancy miscarriages,
- In couples who could not achieve pregnancy with assisted reproductive techniques despite multiple applications or who lost their pregnancy due to miscarriage,
- It is applied in cases of chromosomal disorders or genetic diseases associated with severe male infertility.
HOW IS THE PGT TEST DONE?
- Whether the patient is suitable for PGD is evaluated by the reproductive health specialist, genetic counselor and the doctor of the related disease.
- The couple is prepared for the IVF procedure.
- The egg taken from the mother is fertilized in the laboratory with the sperm taken from the father.
- 1-2 blastomere cells are removed from the obtained embryo by biopsy by embryologists
- Cells obtained by biopsy are prepared and tested according to the method to be applied.
- Embryos with genetic diseases or chromosomal disorders are selected and discarded and healthy embryos are transferred to the mothers womb.
Eyelid Aesthetic
Who is Eyelid Aesthetics (Blepharoplasty) suitable for?
Eyelid aesthetics are mostly performed by individuals over the age of 35. It is possible for anyone with a medical need to have it done at any age. One of the first structures on the human face to show aging is the upper eyelid. Eyelid aesthetics (Blepharoplasty) surgery cannot stop the ongoing aging of the eyelids; However, the tired look on the face can be stopped for about 10 years.
How is upper eyelid aesthetics performed?
Upper eyelid aesthetics (Blepharoplasty) or droopy eyelid surgery is the process of removing excess skin and fatty tissue in the area due to loss of skin tension. The surgery scar does not attract much attention as it will remain on the upper eyelid and will be open during the day.
However, to prevent the scar from being visible, an incision is made at the eyelid fold line and aesthetic stitches are applied. Of course, this deformation in the skin does not only occur on the eyelid, so it gives better cosmetic results when applied together with forehead lift and eyebrow lift operations.
In addition, interventions such as upper eyelid aesthetics (Blepharoplasty) and almond eye aesthetics are also frequently preferred by patients.
How is lower eyelid aesthetics performed?
The fat pads located on the cheekbones atrophy (weaken) with the aging process and the effect of gravity. This condition causes signs of aging in the form of collapse or edema under the lower eyelid and prominent laugh lines around the mouth. The lower eyelid should be evaluated by your physician and checked for bagging and sagging. The type of treatment should be evaluated. If surgery is required, the specialist physician should initiate the planning and process. In lower eyelid aesthetics, the surgical incision is made just below the eyelashes. The skin is lifted and the fat packets there are removed. If under-eye sunkenness continues after surgery, under-eye fat injection may be required after recovery.
How long does Eyelid Aesthetics (Blepharoplasty) surgery and post-operative recovery take?
After Eyelid Aesthetic Surgery, patients do not experience serious pain. Nutrition and movement are allowed provided that it is not heavy. The patient is discharged on the same day and is evaluated again the next day and 5 days later. Stitches are often dissolvable. However, when necessary, the stitches can be removed painlessly without waiting for them to dissolve. After the 5th day, you are allowed to shower and transition to normal life. In
order to reduce the scar in Eyelid Aesthetics, scar reducing creams are sometimes recommended to patients.
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Neurosurgery
Neurosurgery is a medical specialty focused on the surgical treatment of disorders related to the brain, spine, and nervous system. It involves both the diagnosis and the treatment of conditions that affect the central nervous system (CNS) and peripheral nervous system (PNS).
Here are some key areas within neurosurgery:
Brain Surgery: This includes procedures to treat brain tumors, traumatic brain injuries, aneurysms, and neurological disorders like epilepsy and Parkinson's disease. Neurosurgeons may also perform surgeries for congenital abnormalities or infections of the brain.
Spinal Surgery: Neurosurgeons often address spinal issues such as herniated discs, spinal stenosis, and spinal cord injuries. They may also perform surgery for scoliosis or other deformities of the spine.
Peripheral Nerve Surgery: This involves the surgical treatment of nerve injuries, entrapments, and diseases affecting the peripheral nervous system, like carpal tunnel syndrome.
Neurosurgery can range from minimally invasive procedures using advanced technologies to complex open surgeries that require detailed precision. It is closely related to other specialties such as neurology, radiology, and rehabilitation medicine.
Md. ERSAD BATMAZ
MD. ERSAD BATMAZ, has graduated from GATA Military Medical Faculty. He completed his specialty training at GATA Haydarpaşa Training Hospital. He started to work as a Gynecology and Obstetrics specialist in Erzincan Military Hospital in 1990. After 3 years of duty at Erzincan Military Hospital, he served in Kayseri Military Hospital and Ankara Mevki Military Hospital.
Ersad Batmaz, who served as the Head Physician in Kayseri Maternity Hospital in 2002, established Private Hüma Hospital, which is the first and only Gynecology and Maternity Hospital in Kayseri, in 2004.
Since 2004, he has been working as the Chairman of the Board of Directors and Obstetrics and Gynecology Specialist at Hüma Hospital with 31 years of experience as a physician.
In addition to his successful operations in gynecological and oncological surgery, he has performed 8.195 surgeries and 7.168 deliveries so far. Successful operations in female gynecological cancers, especially Wertheim (Radical Hysterectomy) Operations and Lymph Dissection, are in the first place.
In addition to this, laparoscopic surgeries, Vaginal Hysterectomy, surgery to repair structural defects of the uterus, removal of intrauterine polyps and fibroids, diagnostic laparoscopy for infertility diagnosis and treatment, hysteroscopic operations, endometriosis surgeries, ovarian cysts operations, postpartum vaginal incontinence operations. With its success, it is often mentioned
All the operations performed by MD. Ersad Batmaz
GYNECOLOGICAL OPERATIONS;
• Wertheim (Radical Hysterectomy) Operations
• Abdominal Hysterectomy
• Vaginal Hysterectomy
• Laparoscopic Hysterectomy
• Ovarian cyst operations
• TAH BSO
• Vaginal cuff prolapse repair
• Myomectomy
UROGINECOLOGICAL OPERATIONS;
• Rectocele
• Cystocele (Urinary Incontinence)
• Rectosystocele
• Operation Marshall- Marcetti Kranz
CLOSED SURGERY
• Laparoscopic surgeries
• Laparoscopic myoma removal
• Laporoscopic Removal of Ovarian Cysts
• Laparoscopic Endometriosis surgeries
• Diagnostic laparoscopy for infertility diagnosis and treatments
HYSTEROSCOPIC SURGERIES
• Surgery for Repairing Structural Disorders of the Uterus
• Surgery to remove intrauterine polps, myomas
GENITAL AESTHETIC OPERATIONS
• Perinoplasty
• Labiaplasty
• Enlargement of Vaginal Stenosis
OBSTETRIC OPERATIONS
• Normal birth
• Birth in water
• Cesarian section
Md. AKİF YILMAZ
AREAS OF INTEREST
Pregnancy Follow-up and Childbirth Risky Pregnancy Follow-up
Gynecological Surgeries
Genital Aesthetics
Treatment of Vaginal Infections
Childbirth in water
EDUCATION
Pregnancy Follow-up and Childbirth Risky Pregnancy Follow-up
Gynecological Surgeries
Genital Aesthetics
Treatment of Vaginal Infections
Childbirth in water
EDUCATION
Medical Training : İstanbul University
Speialist Training : Gülhane Military Medical Academy
EXPERIENCE
2006 - Currently :Private Hüma Obstetrician and Gynecology Hospital
Dietician Fatma Aybike BOZOKLU
Education:
2023 Nuh Naci Yazgan University faculty of health sciences
Work experience:
Çapa Faculty of Medicine Oncology Institute 2022
Areas of interest:
Nutrition in diseases
Nutrition after gastric sleeve surgery and stomach botox
sports nutrition
Pregnant and Breastfeeding Nutrition
Nutrition in diabetes
Baby-child-adult nutrition
Getting fat
Allergy-food intolerance and nutrition
Losing weight
Adequate balanced and healthy nutrition
Nutrition in eating behavior disorders
weight maintenance
institutional nutrition
sports nutrition
Md. ADEM ARIK
INTEREST AREAS
Premature Baby Follow-up and Treatment
Neonatal Intensive Care Treatments
Neonatal Jaundice
Healthy Child Follow-up
Growth Follow-up and Evaluation in Children
Infection in Children
Respiratory Disorders in Children
Loss of Appetite in Children
EDUCATION
Hacettepe University Faculty of Medicine
Atatürk University Faculty of Medicine Child Health and Diseases Clinic
WORK EXPERIENCE
2021 – Present Private Hüma Gynecology and Obstetrics Hospital
2018-2021 Kayseri City Hospital
2012 -2018 Kayseri Education and Research Hospital
2010 – 2012 Kırıkkale State Hospital
2008 – 2010 Private Elif Children's Center
2005 -2008 Kırıkkale Gynecology and Obstetrics Hospital
2002 -2005 Keskin State Hospital
MEMBERSHIPS
Kayseri Medical Chamber
Md. Seyfi Şahin
EDUCATION
Specialization: Erciyes University Faculty of Medicine
Medical Education: Ankara University Faculty of Medicine
WORK EXPERIENCE
1982 – Specialization: Private Clinic
2003 – Çare Medical Center
2007 – Dr. Seyfi Şahin ENT Center
2017 – Magnet Hospital
2019 – Sistem Hospital
2025 – Hüma Hospital
AREAS OF INTEREST
-
Ear diseases
-
Tinnitus
-
Hearing loss, vertigo, and balance disorders
-
Throat diseases and surgery
-
Recurrent upper respiratory tract infections
-
Nasal obstruction
-
Endoscopic sinus and skull base surgeries
-
Head and neck tumors
-
Hoarseness and laryngeal diseases
WHAT IS OVACULAR OVER STIMULATION SYNDROME? HOW IS THE TREATMENT?
“Ovarian hyperstimulation syndrome”, also known as Ovarian Hyperstimulation Syndrome (OHSS), in the most basic way; It can be explained as a reaction to the hormones given to women for the development of the ovaries. During IVF treatment, women are given hormone drugs to stimulate and support egg development. When these hormone drugs stimulate the ovaries more than necessary, the syndrome of overstimulation of the ovaries occurs.
How Ovaries Stimulation Happens?
Ovarian hyperstimulation syndrome (OHSS) is an undesirable consequence of IVF treatment. Although the aim of IVF treatment is to develop a large number of eggs, OHSS may occur if more than a certain number of eggs develop.
Women with polycystic ovary syndrome are much more likely to have ovarian overstimulation syndrome. Excessive response to the drugs given to stimulate the ovaries prepares the ground for encountering this syndrome. During the stimulation of the ovaries, there is a fine line between stimulating the desired number of eggs and over-stimulating the ovaries. It is not always possible to determine this point clearly. When there is overstimulation, reducing the dose of ovarian stimulating drugs and not giving the drug for a day or more, if needed, can prevent the excessive rise of estrogen.
Symptoms of ovarian hyperstimulation syndrome can be mild, moderate or severe. These symptoms are;
-Increased ovarian size
- Abdominal pain, bloating, shortness of breath, decreased urination
-Fluid accumulation in the abdominal cavity
-Coagulation disorders
It can be seen as fluid collection in the chest cavity. It is extremely important to follow these situations closely and to get medical support when necessary.
How is Ovarian Overstimulation Syndrome Treated?
OHSS treatment is carried out to relieve the expectant mother, reduce ovarian activity and prevent complications. However, OHSS can be performed in two different ways as drug and surgical treatment. In mild cases, no additional treatment is required other than outpatient follow-up and severe physical activity restriction, and the patient can usually recover in 10-14 days. Moderate and severe cases may require hospitalization and treatment. In most cases, women who have had OHSS can continue IVF. It is still possible to become pregnant despite OHSS, but these symptoms may worsen if pregnancy occurs. In this case, the patient is followed closely under the supervision of a doctor.
WHAT IS SECONDARY INFERTILITY?
In some cases, it is not enough if only the reproductive system is healthy for pregnancy to occur. Along with the reproductive system, it is extremely important for the pregnancy process that many factors work in harmony with each other. Depending on the factors that affect the process, pregnancy may not occur in people. This condition can also be observed if the person has already become pregnant or had a healthy birth.
Infertility, which occurs as a result of a couple having regular sexual intercourse for 12 months and not being able to get pregnant even though they are not using a method of protection, can be seen in two different ways. Never before pregnancy occurs when primary infertility; a live birth or not, regardless of if at least one pregnancy occurred, secondary (secondary) infertility is defined as.
You can continue reading our article about what is secondary infertility, what are its causes, important risk factors and treatment topics.
Causes of Secondary Infertility
Secondary infertility can occur due to both of the couples. The causes of secondary male infertility; the presence of varicose veins in sperm vessels, known as varicocele, infections, traumas and testicular tumors can be listed in the form of. The causes of secondary infertility in women are causes such as differences in ovulation patterns, damage or blockage of the tubes, deterioration of the structure of the uterus, and cervical and cervical cancer, especially as age progresses.
Autoimmune diseases and sexually transmitted diseases are also among the causes dec lead to secondary infertility.
In order to determine which of the many factors considered to cause the development of secondary infertility in people and to make appropriate planning, the couple should consult a specialist physician.
Risk Factors for Secondary Infertility
One of the most curious points about secondary infertility is the risk factors of secondary infertility. Many risk factors can cause the development of secondary infertility in people. These factors;
• Progression of age
• Different disorders such as polycystic ovary syndrome
* Excess weight
• Previous miscarriages
* Stress
* Alcohol, smoking and substance use
It can be sorted as follows. Along with all this, various factors that may differ from person to person can also lead to the development of secondary infertility in people.
Treatment of Secondary Infertility
The causes of secondary infertility, which are an obstacle to a person's conception, can be studied in an extremely wide range. For this reason, first of all, the points that prevent a person from becoming pregnant should be determined by taking into account different factors and an appropriate treatment plan should be developed accordingly. As a result of the evaluations made by taking the patient's history, vaccination and IVF treatments may be recommended to support conception. In order to determine the condition, specific infertility tests can be administered to people after a physical and pelvic examination. The ovulation test and other hormone tests are some of them.
As Huma IVF center, we continue to be with you in this process with our expert staff. For all the questions you have in mind, you can contact us by checking out our experts on our website.
What Is insemination? How Is It Done?
There are 2 treatment methods most commonly preferred by couples who want to have a baby but do not have a baby for various reasons. One of them is in vitro fertilization treatment and the other is insemination method. In our article, we will try to answer the most frequently asked questions about the vaccination method, what is insemination and how it is done.
What is insemination?
If couples cannot get a pregnancy result after one year after unprotected sexual intercourse, infertility is diagnosed. Infertility can have many causes, depending on the woman and the man. Thanks to science and developing technology, there are now many treatment methods for infertility. One of these methods is the vaccination method. In its simplest form, the method of vaccination is to prepare the sperm in the laboratory and inoculate the woman's uterus at the time of ovulation to ensure fertilization. In order for the vaccination method to be performed, some tests must be done to make sure that there is no problem in the uterus of the expectant mother. In addition, at least one of the tubes of the expectant mother must be in working condition. The purpose of the vaccination method is to select the motile, normal sperm with a higher probability of fertilization and send them to the uterus of the expectant mother. Thus, it will be more likely to be fertilized with eggs and selected sperm supported by drugs or pills.
How is insemination done?
Before the insemination method, the development of the egg is supported with pills or low-dose injections given to the expectant mother. During this process, the egg is tracked. When the eggs mature and reach certain sizes, a cracking needle is given and the eggs are cracked. Just at this time of cracking, the sperm prepared in the laboratory are transferred to the uterus. Thus, the most suitable time of ovulation is provided for the woman and the best sperm are transferred to the uterus at the right time. insemination is a natural method. Only sperms that will increase the probability of fertilization are carefully selected. From the sperms taken from the father-to-be, those that are of good quality, motile and washed in a certain number, that is, processed. As Hüma IVF Center team, we tried to give information about what is insemination and how it is done in our article. We hope it was useful. You can contact us via our website to get more detailed information about IVF treatment or to ask your questions.
WHAT IS EMBRYO GLUE? HOW AND WHO USE IT? IS THE SUCCESS RATE HIGH?
As couples who want to become parents cannot become parents with natural methods, couples resort to some treatments. In vitro fertilization is the first treatment method. And IVF treatment is a very advanced and effective treatment method. Some applications in IVF treatment are important for the positive outcome of the treatment. Embryo glue application, which is one of the important application methods, is a very successful application. Embryo glue is one of the applications without any known risk. As a result of the studies, it was concluded that it did not increase the risk of miscarriage or pregnancy complications. Now we will provide you with detailed information about embryo glue. We wish you pleasant reading.
What is Embryo Adhesive?
Embryo glue, a method used in IVF treatments, is a kind of liquid embryo culture medium enriched with a substance called hyaluronan, in which embryos are left before transfer to the uterus of the expectant mother.
Hyaluronan is a natural carbohydrate found in all tissues in the body. The embryo needs an environment rich in carbohydrates, amino acids and protein in order to develop healthily inside. In addition, embryo glue is also called embryo glue because it reduces the ability of the embryo to move in the uterus.
How and Who Is Embryo Adhesive Used?
Embryo adhesive application is done as follows:
After the embryos are developed in the laboratory for 3-5 days, the most suitable one for embryo transfer is selected.
· The most suitable embryos selected for transfer are taken into the embryo glue.
· Embryos are kept in this environment for about 30 minutes.
· After standing, the embryos are taken from the culture dish and drawn into the catheter (a thin tube).
· The catheter is then passed through the cervix under ultrasound guidance and the embryos are transferred to the uterus.
In expectant mothers who have repeated in vitro fertilization failure using the embryo glue method,
It is used in couples who want to have children over the age of 35, when the quality of the embryo depending on the egg or sperm is not very good.
Is the Success Rate High in Embryo Bonding?
Embryo adhesive is one of the most frequently used applications for the last 10 years in order to increase the chance of success in IVF treatment. Experts were unsure about the effectiveness of embryo glue at first. However, in recent years, the effectiveness of embryo glue has been observed as a result of scientific research. Today, embryo glue is applied by various IVF centers. Hüma IVF Center is one of these centers.
The high concentration of hyaluronan concentrates the embryo glue similar to the tissue of the fluids in the womb, so that better mixing of these fluids minimizes the mobility of the embryo. In addition, hyaluronan acts as a bridge between the embryo and the inner wall of the uterus by binding to the inner wall of the uterus and the molecules on the surface of the embryo. In this way, it helps the embryo to attach to the uterus.
We aimed to give you information on this subject by considering the embryo glue method. We talked about how this method is applied and its success rate.
WHAT IS POLYCYSTIC OVER SYNDROME? WHAT ARE THE SYMPTOMS AND TREATMENT METHODS OF POLYCYSTIC OVER SYNDROME?
Polycystic ovary syndrome, which occurs due to irregular hormone production, is one of the most common hormonal disorders in women of reproductive age. Polycystic ovary syndrome, which is seen in one out of every 10 women, is manifested by menstrual irregularities such as abortion or long-term periods. So, what is polycystic ovary syndrome, the incidence of which has increased in recent years? What are the symptoms of polycystic ovary and treatment of polycystic ovary?
What is Polycystic Ovary Syndrome?
Follicles in different developmental stages in a normal ovary are selected during the menstrual period and become secondary and mature follicles. This selected follicle is then thrown out of the ovary with ovulation. In polycystic ovary syndrome, there are many immature follicles in the ovary and ovulation does not occur. Some changes are also seen in the hormone production of the ovary.
WHAT IS POLYCYSTIC OVER SYNDROME? WHAT ARE THE SYMPTOMS AND TREATMENT METHODS OF POLYCYSTIC OVER SYNDROME?
Polycystic ovary syndrome, which occurs due to irregular hormone production, is one of the most common hormonal disorders in women of reproductive age. Polycystic ovary syndrome, which is seen in one out of every 10 women, is manifested by menstrual irregularities such as abortion or long-term periods. So, what is polycystic ovary syndrome, the incidence of which has increased in recent years? What are the symptoms of polycystic ovary and treatment of polycystic ovary?
What is Polycystic Ovary Syndrome?
Follicles in different developmental stages in a normal ovary are selected during the menstrual period and become secondary and mature follicles. This selected follicle is then thrown out of the ovary with ovulation. In polycystic ovary syndrome, there are many immature follicles in the ovary and ovulation does not occur. Some changes are also seen in the hormone production of the ovary.
WHAT IS THE SPERMIOGRAM TEST FOR ANALYSIS OF SPERM CELL?
Parents who want to have children generally prefer the most common in vitro fertilization treatment. Before this treatment, both mother-to-be and father-to-be go through many tests. Father-to-be passed; The first of the tests to test for infertility or other problems is the sperm test, also known as the spermiogram test. What is the spermiogram test for the analysis of the sperm cell? How is spermiogram done? What do spermiogram test results mean? We will answer all these questions for you in detail below. We recommend that you continue reading our article to have detailed information about the sperm test.
What is a test (spermiogram)?
Sperm test done to men; It is a test to determine sperm health, sperm count, and whether the sperm are moving correctly in the channels. As a result of the sperm test, if the sperm shape is normal and there is a sufficient number of sperm, it is concluded that your reproductive ability is high. However, in some cases, men may have low sperm count or the ability to reproduce despite having abnormal semen. That's why doctors order a second test for the accuracy of the results. If your results are normal in your first sperm test, you give the other test and if it is normal, these two normal tests show that you do not have an infertility problem. If there are different conditions, your doctor may order other tests.
If there is no semen or sperm as a result of the sperm test, this may indicate that your ducts are blocked. If this is the case, your doctor will plan different surgeries to open the channels.
Issues and Precautions to Consider While Giving Sperm Sample
There are important points to be considered before giving the sperm sample and while giving the sperm sample. Among the things to be considered before giving a sperm sample, we can count that "men should abstain from sexual intercourse for 3 days". Fasting for 3 to 5 days is sufficient. These numbers are important because if you fast for less than 3 days, the sperm count may be low as a result of the sperm test. For this reason, we can say that fasting between 3 and 5 days is sufficient. It is possible to list the issues to be considered while giving a sperm sample as follows;
· Storing the sample in a sterile environment: It is important to protect your sample from the outside environment for a healthy and accurate spermiogram test result. If a sterile environment is not provided, the test result may be inaccurate. Therefore, do not put your hands, especially sample containers, etc. It is important that you keep it as sterile as possible.
· Protecting the delivered sperm from heat: Another important point is to keep your sample away from extreme temperature changes after ejaculation. Because these extreme temperature changes negatively affect spermatozoa. Ideal temperatures for the sample cup should be between 20°C and 37°C.
· Sperm volume, amount: Volume is extremely important in the sperm test. Your sperm volume is expected to be at least 1.5 ml. The reason why you cannot reach the lower limit of 1.5 ml may be external discharge during ejaculation. It is important to be careful about this.
· Use of lubricating foreign substances during the sperm test: It is important not to use any lubricant during the sperm test because these substances seriously affect the sperm parameters. External factors with such an impact can lead to wrong conclusions.
How is the Sperm Test Done?
For the sperm test, you must first be at the IVF center or hospital. There are rooms specially prepared for men in hospitals or IVF centers. In these rooms, men give their sperm in a special container. For the effectiveness of the sperm test, the sperm sample is immediately delivered to the laboratory. The sperm sample given in the laboratory is subjected to many processes and the best quality sperms are selected. The purpose of the procedures is to examine the sperm count, motility and shape in the semen and to reach quality sperm as a result.
Apart from the hospital, sperm samples can be placed in a container and brought to the hospital in the home environment. However, this is highly not recommended. Even if this is accepted, the sperm samples should be brought to the hospital and delivered within half an hour.
Issues and Precautions to Consider When Analyzing Sperm Sample
For the sperm test, you must first be at the IVF center or hospital. There are rooms specially prepared for men in hospitals or IVF centers. In these rooms, men give their sperm in a special container. For the effectiveness of the sperm test, the sperm sample is immediately delivered to the laboratory. The sperm sample given in the laboratory is subjected to many processes and the best quality sperms are selected. The purpose of the procedures is to examine the sperm count, motility and shape in the semen and to reach quality sperm as a result.
Apart from the hospital, sperm samples can be placed in a container and brought to the hospital in the home environment. However, this is highly not recommended. Even if this is accepted, the sperm samples should be brought to the hospital and delivered within half an hour.
Issues and Precautions to Consider When Analyzing Sperm Sample
After the sperm test is given by the prospective fathers, it is examined in the laboratory environment. This examination takes approximately 1-2 hours and after the first hour, active results begin to be obtained. However, sometimes different situations can be encountered. For example, the test is given, but no sperm can be seen when looked at. In these cases, sperm are taken again and centrifuged. When faced with such a situation, the time may be extended. If there is no additional test to be done, the test results are immediately available in an average of 1-1.5 hours.
What Do Sperm Test Results Mean?
Sperm test results can be evaluated in many ways. Sperm analysis evaluates the sperm by analyzing it from various aspects. We can list these analyzes as follows:
· Sperm count and density:
Sperm count describes the number of sperm in 1 ml of semen. The World Health Organization advocates that a normal sperm count should be at least 15 million per ml or at least 39 million per sample. Having fewer sperm than these numbers indicates a low sperm count.
· Sperm morphology:
Non-abnormal sperm have a long tail and oval head. Morphology refers to the size and shape of the sperm a person has. Sperm that do not have a normal size or are weak in shape have difficulty reaching the egg and fertilization.
· Sperm motility:
The ability of sperm to move efficiently is one of the most important factors for fertilization.
· PH level of sperm:
When the pH level is too high or too low, it can affect the health of sperm and its ability to pass through the female reproductive tract.
Apart from these, sperm health is examined by looking at many factors such as semen volume, liquefaction, and seminal fructose levels while performing the sperm test. After examining all factors in detail, the results are examined and reported to the patient.
What is the Sperm Test Result of a Healthy Individual?
Low sperm count can have many different causes. The first reason is smoking addiction. Smoking addiction is one of the important factors that reduce the sperm count. In addition to smoking, alcohol and drug addiction also affect sperm count. Sperm count can also be adversely affected when there is a deficiency in hormones, depending on the clogged ducts.
Hormones are one of the important factors for reproduction on their own. Since the deficiency in reproductive hormones directly affects sperm production, it increases the possibility of encountering problems in reproduction. Apart from these, mistakes made by couples who want to have children also affect the sperm count. Using natural products unconsciously and continuing to use them uncontrollably, without knowing the limit, does harm to the person instead of providing benefits. Long-term treatment and drugs used during the treatment also affect the sperm count.
IMSI in Sperm Selection
The IMSI (Intracytoplasmic Morpholgically Selected Sperm Injection) method is the magnification and examination of even the smallest cells using special microscopes. In the past, in the microinjection procedures applied in IVF treatments, living sperm cells could be enlarged up to 400 times. However, with IMSI, sperm can now be enlarged between 6000 and 8000 times. It is possible to examine and detect in detail the disorders called "vacuoles" that indicate the intracellular structures of the sperm and their genetic damage.
The IMSI technique is an extremely useful method. Selected sperm injection; It allows advanced morphological analysis of sperm without damaging the living sperm cell. Sperm with the highest fertilization ability are selected and a high chance of fertilization between 20% and 40% can be obtained with the applied microinjection application.
Precautions to be Considered for Sperm Quality
Couples who want to have children should pay attention to egg and sperm health and be careful in this regard. There are many factors that affect sperm quality, such as those that affect egg quality. One of these factors is undoubtedly a healthy diet. A healthy diet is extremely important for every organ in the body, of course also in sperm health.
In addition, exercise is very important in making you more vigorous and increasing your body's stamina and activity. Regular exercise will make you recover in a short time and will positively affect both your mental and physical health. Alcohol and smoking are substances that affect reproductive cells and should be avoided. This is a proven fact as a result of research. If we gather all these under one title, we can say that one should take care of his own health. Nutrition, avoiding alcohol, smoking, exercising regularly will first affect your health and therefore your sperm quality.
This process, which is sensitive and special for couples who want to have a child, is extremely important for them. In this process, prospective parents experience excitement on the one hand and a lot of stress on the other. Hüma IVF Center, which understands the emotions experienced best and does not spare its support by being by their side throughout the process, is always ready to accompany you.
What is infertility, what are its symptoms, what kind of treatment method is applied?
What is infertility, what are its symptoms, what kind of treatment method is applied?
Infertility, as it is called in the medical literature, is one of the most important health problems affecting millions of people around the world. In addition to being a health problem that can be seen in women and men, today the number of couples who cannot have children is quite high. According to researches, 10-15% of couples who have unprotected sexual intercourse for a year cannot have a child.
In our article, about infertility, one of the most important health problems in the world; We will try to give short answers about what is infertility, what are the symptoms of infertility and how to apply the treatment method.
What is infertility?
According to the definition of the World Health Organization, infertility; “Failure to conceive within one year of a sexually active couple who had unprotected intercourse without using contraception.” is the status. In other words, in order to be able to talk about infertility exactly, couples must have unprotected intercourse for one year and be unable to conceive. Infertility is one of the important health problems affecting 25% of the world population. In the researches, it can be seen depending on the woman or the man.
What are the symptoms of infertility?
The most important sign of infertility for both men and women is the inability to get pregnant despite having unprotected sexual intercourse for one year. However, some symptoms seen in men and women can be seen as a sign of infertility and an examination may be required accordingly.
infertility in women;
- Imbalances in the menstrual cycle can be considered as a symptom. If you have periods longer than 35 days or shorter than 21 days, you should definitely see a specialist.
- If you are in your 30s and younger, it is expected to get pregnant within 1 year.
- If you are in your 35s and 40s, pregnancy is expected within 6 months. If pregnancy does not occur within 6 months, it is useful to see a doctor.
Infertility in men;
- Sexual dysfunctions are considered a sign of infertility. Example; impotence, ejaculation, such as strain.
- Pain, swelling or a lump in the testicle area during sexual intercourse may also be a sign of infertility.
- Infertility in men can often be caused by hormonal disorders.
Although all these symptoms are not exactly the cause of infertility, they are among the factors affecting it and may be symptoms of infertility.
What kind of treatment method is applied in infertility?
There can be many different reasons for the occurrence of infertility. Therefore, first of all, the causes of infertility are investigated. Different treatment methods are tried according to the detected cause. Some of the treatment methods applied are as follows;
- IVF Treatment
- Vaccination
- Microinjection
In vitro fertilization is one of the most well-known and most preferred and effective treatment methods among other treatment methods.
As Hüma IVF Center team, we tried to give information about what is infertility, what are its symptoms and what kind of treatment method is applied in our article. We hope it was useful. You can contact us via our website to get more detailed information about infertility or to ask your questions.
WHAT IS ADENOMYOSIS AND WHAT ARE THE CAUSES? WHAT IS THE RELATIONSHIP OF ADENOMYOSIS AND INfertility? WHAT IS ADENOMYOSIS TREATMENT?
Adenomyosis is a female disease that occurs in women, especially as age increases. Women with adenomyosis experience extremely painful, painful and excessive bleeding menstrual periods. This heavy menstrual period also affects the daily life of women with adenomyosis. In addition, it causes anemia. If you are experiencing these problems and want to know more about Adenomyosis, you can continue reading our article.
What is Adenomyosis?
The uterus contains an inner lining of the uterus called the endometrium. The task of this inner membrane is to limit the inner surface of the uterus. The inner membrane inside the uterus is renewed every month with the menstrual period and in some women it moves towards the uterine muscle layer. Adenomyosis occurs as a result of thickening of the inner membrane in the uterine muscle layer.
There are two types of adenomyosis: benign and malignant. It is a benign type that is usually seen in women, but some women may also have a malignant type that requires surgery and poses a risk.
Women with adenomyosis have difficult days during their menstrual periods. During this period, they may have to cope with excessive pain and excessive bleeding. Again, they may feel uncomfortable bloating before the menstrual period and may experience pain and pain during sexual intercourse.
What are the Causes of Adenomyosis?
Although the causes of adenomyosis disease in women are not known clearly, it is known that hormones such as estrogen, prolactin, and progesterone trigger this ailment. Apart from this, external interventions in cesarean deliveries, surgical cuts or inflammation of the inner lining of the uterus during birth trigger the cells that regulate the uterus to leave their borders and cause adenomyosis. Development-related adenomyosis can also be seen. During the developmental process, the endometrial accumulation formed between the muscles during the first formation of the fetus in the uterus may cause adenomyosis.
What is the Relationship Between Adenomyosis and Infertility?
The age at which adenomyosis is most common is people between the ages of 40 and 50. Adenomyosis is a female disease related to the uterus. For this reason, we can say that adenomyosis is directly related to infertility and pregnancy. Adenomyosis is a disease whose incidence increases with increasing age, so infertility and adenomyosis can be seen together when pregnancy is considered in older women. Expectant mothers who encounter this situation can achieve their dreams of having a child by trying the in vitro fertilization method after receiving adenomyosis treatment.
What is Adenomyosis Treatment?
Experts have done many studies to treat adenomyosis disease and as a result, they have found various treatment methods. We can talk about hormonal therapy as the first treatment method. With hormonal therapy, it is tried to relieve the pain caused by adenomyosis and to reduce the excess blood. For this, birth control pills, temporary menopause treatments or medicated spiral methods can be used. As a second method, we can consider MRI Focused Ultrasound. In MRI focused ultrasound treatment, high-intensity heat waves are used to destroy the tissue that causes adenomyosis. Another form of treatment is hysterectomy. This form of treatment is the most permanent solution, but because it results in the removal of the uterus, it is applied only to women who do not plan to have children or in severe cases that do not respond to any treatment.
In this article, we discussed adenomyosis, which is common in older women. What is adenomyosis, what are the causes of this disease, what is the relationship between adenomyosis and infertility, and what are the treatment methods for this disease, based on all these questions, we have made detailed explanations about adenomyosis for you. We wish you a pleasant reading. You can visit our website for more.
WHAT IS A REDUCED OVER RESERVE (AMH)?
Ovarian reserve, known as the ovary, is a term used to determine the fertilization ability of the ovary to provide egg cells and to determine the probability of a successful pregnancy. With the advancing age of the expectant mother, the number of egg cells obtained from the follicles for pregnancy decreases. decreased ovarian reserve (AMH); It is a condition in which the ovaries begin to lose their normal production capabilities, reducing fertility. Decreased ovarian reserve reduces women's chances of conceiving spontaneously or with treatment. However, it is aimed to minimize the effects of this situation with various methods. The main causes of decreased ovarian reserve can be listed as follows:
· Smoking,
Chronic diseases,
Coffee consumption
Age of the expectant mother,
Genetic abnormalities (X chromosome abnormalities)
Various treatments (such as radiation for cancer)
· Having undergone ovarian surgery.
You can continue reading our article for reduced ovarian reserve and all its details.
How to Identify Decreased Ovarian Reserve?
Decreased ovarian reserve is determined by examining the hormone tests to be performed on the 2nd or 3rd day of the menstrual period of the expectant mother. FSH hormone gives information about the status of ovarian reserves. If the FSH value is higher than 10, it indicates decreased ovarian capacity.
The best indication of the capacity of the ovaries is the vaginal ultrasound. Existing and developing egg structures can be easily detected here. If there are less than six egg structures in the total ovaries, decreased ovarian reserve may be in question.
In summary, decreased ovarian reserve; It can be understood by clinical evaluation of the person, vaginal ultrasound, measurement of AMH hormone and FSH hormone in the blood.
Can a Woman with a Decreased Ovarian Reserve Get Pregnant?
Existing studies show that women with reduced ovarian reserve can become pregnant both spontaneously and with IVF treatment. Although it has been shown that high serum FSH levels in women are associated with low pregnancy rates, it is not sufficient to make a decision based on this alone. Egg cells also regulate their size under the influence of genetic factors. The speed of the aging process of the ovaries varies greatly among women, except for the age factor. In addition to the successful results of endocrine tests and imaging methods in the numerical evaluation of ovarian reserve, their values in determining the chance of pregnancy remain at a limited level.
The chance of conceiving of a woman who is determined to have decreased ovarian reserve with ovarian reserve tests and clinical evaluations by specialist physicians can be increased by applying appropriate ovulation treatment protocols. Patients with reduced ovarian reserve can become mothers with different techniques today. In order to determine these methods, it is important to plan and apply special treatment methods suitable for patients by considering various factors.
How Is Decreased Ovarian Reserve Treated?
Currently, there is no treatment for decreased ovarian reserve that prevents or slows down ovarian aging. In addition, lifestyle changes have an extremely important role in preventing premature aging of the ovaries and in order to ensure the healthy continuation of egg quality, that is, to increase egg reserve and quality. These;
· Eating a balanced and healthy diet,
Doing regular exercise,
Quality and adequate sleep,
Avoiding chemicals, high glycemic index and fast food style foods,
Not to use substances such as cigarettes and alcohol,
· Using antioxidant drugs under the control of a physician.
If you have decreased ovarian reserve and want to have a child according to your required tests and vaginal ultrasound results, it is extremely important to seek in vitro fertilization treatment in the presence of a specialist doctor, without wasting time.
As Hüma IVF Center, we choose the most appropriate treatment method for you, apply it and continue to serve.
WHAT IS BLASTOCYST TRANSFER? WHAT ARE THE ADVANTAGES OF BLASTOCYST TRANSFER?
Blastocyst transfer, which is one of the advanced in vitro fertilization techniques applied today, is a method that offers a much higher chance of pregnancy to couples who want to have children. The blastocyst transfer method, which is a method that minimizes the possibility of multiple pregnancy, which is frequently encountered in IVF treatments, supports families in making their plans to have a child more effectively. The blastocyst is defined as the 5th or 6th day of the egg becoming an embryo. Before transfer, one or two embryos of the highest quality are selected and the transfer is carried out. This method is among the most important processes of IVF treatment. What is blastocyst transfer, what are its advantages and risks? You can continue reading our article, which includes the details of blastocyst transfer with questions.
What is blastocyst transfer?
Blastocyst transfer, which has an extremely important place in the IVF treatment process, is the process of transferring the embryo created in the laboratory environment to the woman on the 5th or 6th development day. Embryos are followed in incubators in the laboratory and when they reach the blastocyst stage, transfer to the uterus is performed. Blastocyst transfer has many positive contributions to the IVF process, such as enabling better quality embryo transfer and reducing the risk of multiple pregnancy.
What are the advantages of blastocyst transfer?
Blastocyst transfer is a method that has been used frequently in recent years, depending on the developing technologies. In the first years of in vitro fertilization treatment, the expected time for transfer was 48 hours, but this period has been extended in parallel with the developments experienced today. In the blastocyst transfer method, embryos with the highest success rate are selected more easily with transfers made after 5 and 6 days. In general, the advantages of blastocyst transfer can be listed as follows;
The chance to achieve better results against recurrent pregnancy failures, thanks to the selection of embryos with better development potential and compatibility with the uterus,
Reducing the possibility of multiple pregnancy by transferring fewer embryos with high viability,
The chance to observe the embryo development more clearly and healthily,
Freezing of embryos at the time when they have the highest developmental power, that is, at the blastocyst stage,
· Allowing different methods to examine embryo viability.
What is the risk of blastocyst transfer?
The condition that can be encountered frequently as a result of blastocyst transfer is the factor of multiple pregnancy. For this reason, some legal restrictions have been imposed on the number of embryos to be transferred in order to be protected from the risks of multiple pregnancy. For our country, this limit has been determined to be a maximum of 2 embryos. By performing 1 or 2 blastocyst transfers in embryo transfer on the 5th day, both the risk of multiple pregnancy is reduced and the chance of pregnancy is increased. The aim of IVF treatment is to achieve a healthy fertilization. In this direction, better quality but less number of embryo transfers will minimize the risks that may be encountered and will facilitate healthy results.
Who is blastocyst transfer suitable for?
Blastocyst transfer can be applied to all couples with a high number of fertilized eggs and good embryo quality on the 2nd day. Since a single embryo can be transferred in the first two attempts under the age of 35, a blastocyst transfer will be made to them, thus preventing multiple pregnancy. In our country, blastocyst transfer is successfully applied and high success rates are achieved. However, the remaining quality embryos after the transfer are successfully frozen with the vitrification method, which is a new and fast freezing technique, giving couples a second chance. You can visit our website for more information and to make an appointment.
CALCIUM IONOPHORE THERAPY
Calcium ionophore therapy is a treatment method applied to ensure a healthy fertilization and to obtain a high pregnancy rate. In order to talk about a healthy fertilization, when the sperm enters the egg, the enzyme in the head part of the egg must be released into the egg and the amount of calcium inside must increase.
If the amount of folfolipase C in the sperm is low, the egg cannot be fertilized because without phospholipase, the calcium rate in the egg does not increase.
Calcium ionophore therapy is an application that increases the amount of calcium in the egg. In the calcium ionophore application, the egg and sperm are first fertilized by micro-injection. After this process, the eggs are kept in a calcium ionophore for a few minutes. The main purpose here is to increase the calcium level that needs to be increased in the egg. In other words, calcium ionophore therapy helps the fertilization of the egg by supporting the reactions that should start in the egg. So, what is calcium ionophore therapy and to whom is it applied? Now we will answer all these questions for you.
What is Calcium Ionophore? To Whom Is It Applied?
It is possible to define calcium ionophore therapy as an application that increases the amount of calcium in the egg. This treatment method is generally applied to the people we will list below. Those people;
Individuals with successive fertilization problems
If very few eggs or sperm are obtained
In cases where no fertilization can be achieved with micro-injection therapy
In patients with “globosperm” of all sperms
Calcium ionophore therapy is applied.
Who Is Fertilized With Calcium Ionophore?
In cases where embryo transfer cannot be performed due to the fertilization step not taking place during IVF treatment, activation of the eggs and fertilization are aimed by using calcium ionophore. Thus, calcium ionophore therapy is applied. With this treatment method, the problem of non-fertilization can be eliminated and treatment can be applied in couples who have non-fertilization problems. This treatment method is also applied to couples who have problems as a result of obtaining a very small amount of egg and sperm. Fertilization is performed with the calcium ionophore treatment method and a high pregnancy rate is obtained.
In this article, we have given the answers to all these questions for you, what is calcium ionophore therapy, to whom this treatment method is applied and in whom fertilization occurs as a result of the treatment.
It may interest you: What is infertility, what are its symptoms, what kind of treatment method is applied?
WHAT IS COMPREHENSIVE CHROMOSOME SCREENING (NGS)?
IVF treatments are supported by a wide range of tests and analyzes to get a healthy result. With the help of these tests, problems that may occur before and after pregnancy are also detected and planning is carried out in this direction. NGS, a genetic analysis technology that allows comprehensive chromosome screening to be performed in embryos, is a test that gives extremely effective results as technological developments gain momentum. With NGS, embryos are scanned quickly and effectively, and genetic problems at the chromosome level are detected before pregnancy. The aim of this method is to select a healthy embryo by performing genetic analysis on embryos before the transfer process and to increase the chances of a healthy pregnancy. You can continue reading our article for the details of the NGS test.
What is Comprehensive Chromosome Screening (NGS)?
It is extremely important that the embryos obtained in IVF treatments are successfully transferred to the uterus. But in some cases, pregnancy may not be achieved. One of the most important reasons why a healthy pregnancy cannot be achieved despite embryo transfer in treatment has been identified as chromosome disorders that occur in embryos. In order to achieve a healthy and successful result in IVF treatments, it is necessary to analyze the embryos in detail and detect chromosomal abnormalities. Previously, the multidimensional and complex structure of chromosomes would have made multiple tests necessary. While this situation is quite time consuming and costly, the NGS (Next Generation Sequencing) test appears as a result of the developing technology today. The NGS method is a newly developed genetic analysis technology that allows comprehensive chromosome screening of embryos. The NGS method allows all embryos to be screened within a short period of time. With NGS, which offers a quick and detailed scan, chromosome-related problems are diagnosed before pregnancy. All 24 chromosomes are scanned with the NGS test.
Comprehensive chromosomal screening practices performed by the NGS method play an extremely important role in diagnosing disorders and have an effect on facilitating healthy outcomes in IVF treatments.
What are the Features of the NGS Technique?
Chromosomal abnormalities are determined by screening with the NGS method. Embryos containing more than two or more cell communities with different chromosomal structures are called “mosaic embryos”. Mosaic embryos are detected more easily with the NGS technique. After these chromosomal abnormalities detected by the NGS test are detected accurately and in detail, the process is advanced by including them in the treatment planning. Compared to the different PGD methods used to date and known, the NGS method provides a high-intensity scanning area, allowing you to detect even some genetic disorders, as well as numerical changes occurring in chromosomes.
What Genetic Defects Can Be Detected with NGS-Based PGS?
Embryos obtained in IVF treatment are evaluated according to various criteria in terms of the characteristics they have, and a healthy result is sought by ensuring the transfer of the embryo with the best developmental characteristics to the uterus. Examination of the developmental characteristics of the embryo under a microscope by classical methods does not give a clear information about the chromosomal state of the embryo. This information is only reached by performing a genetic screening with PGS. Even if the embryos have a good quality structure, they can contain various chromosomal problems, and this can also lead to problems such as early miscarriages, some structural disorders in the developing fetus, or the embryo does not hold on to the uterus. The main purpose of using the PGS method, which is an NGS-based method, is to increase the adhesion of the embryo to the uterus, which is found to have a chromosomally normal structure, to reduce the likelihood of miscarriage that may occur later, and as a result, to increase the likelihood of couples having healthy babies. The NGS-based PGS operation is performed by embryologists who have the necessary education and experience in this regard. The process takes a short time and does not cause any harm to the embryo. The PGS process begins by combining the egg taken from the expectant mother and the sperm taken from the expectant father outside the body. 5. Development of embryos from formed embryos. or 6. on the day when the blastocyst is at the stage, several cells are taken by biopsy without damaging the embryo. These received cells are sent to the genetic laboratory for a scan of 24 chromosomes, while the embryos are frozen. At this point, it is extremely important that the procedure is performed by a qualified embryologist so that the embryo does not get damaged. At the end of this examination, the embryo or embryos whose genetic structure has been determined to be healthy are transferred after completion of intrauterine preparation and pregnancy results that reach higher rates are obtained, especially.
To summarize briefly; NGS-based PGS is a genetic screening method and can be used to detect numerical and structural imbalances in chromosomes. However, single gene diseases, especially those with familial transmission, cannot be detected with the PGS method.
Who are the Groups of Patients Who Can Be Administered NGS?
The benefits of the NGS method, which is a new generation genetic analysis technology, also raises the question of which patient groups this technique can be applied to. Before answering this question, we can state that the intended point of the NGS method is to be able to detect numerical and structural changes in chromosomes. Therefore, we can address the question of which people have these changes more often for groups of patients who can be administered NGS. Groups of patients for whom NGS can be applied can be listed as follows;
· In cases of repeated miscarriage,
· in expectant mothers over the age of 38,
· In severe male infertility,
* In cases of infertility, the cause of which is unknown,
· It is applied in cycles of continuous self-recurring treatment failures.
The NGS method, which is a rapidly developing field, is actively used in many countries today due to its possibilities and facilitating and accelerating effects for the process.
What are the Advantages of Preimplantastone Genetic Screening with NGS?
NGS, a new genetic examination method used to screen for 24 chromosomes in embryos, provides the opportunity to examine and sequence the entire human genome both numerically and structurally in a short period of time, such as a single day. It offers us a revolutionary technology in this aspect. The improved NGS method can detect mosaic embryos better than other PGD methods. The main advantages of Preimplantastone Genetic Screening with NGS are that it allows you to quickly scan a large area of genes, both numerically and structurally. In addition to scanning gene fields numerically and structurally, the NGS method also has advantages such as obtaining a more accurate result with a low margin of error, achieving faster results, and having a lower cost. With this method, 24 chromosome screening can also be performed simultaneously with the study of single gene diseases and HLA typing.
Does NGS Damage the Embryo?
IVF treatments are an extremely exciting period for couples. During this period, in order to obtain a healthy result, various tests are applied to the embryos obtained to determine the success rate. In some cases, couples may have a high risk of genetically abnormal embryo development. Advanced maternal age is one of these conditions. Embryos that are not genetically normal are not suitable for transfer. In order to be able to determine the chromosomal status of embryos and to obtain a healthy result, process planning is carried out in the light of the NGS result. Another confusing situation for couples at this point is whether NGS causes any damage to the embryo during the application phase. Doctors who specialize in their field and NGS performed under appropriate conditions do not pose a danger risk to the embryo. At this point, managing and planning the process in accordance with the needs with a reliable specialist and institution will also be an extremely important step.
Does Pregnancy Always Occur With a Smoothly Detected Embryo?
After the tests and examinations, embryos that do not carry any genetic abnormalities are placed in the uterus. The probability of the occurrence of pregnancy after this procedure develops due to various factors. These factors;
· Women's age
· The amount of ovarian reserve of the woman
* Sperm quality
· Embryo quality
· Ensuring a proper intrauterine environment
· The presence of hydrosalpinx
· Conditions encountered during embryo transfer
it can be sorted as follows. All these factors are among the dec that affect the occurrence of pregnancy. From this point of view, it is impossible to say that pregnancy always occurs with an embryo that is detected without problems.
Studies have shown that age-related embryos are less likely to be chromosomally normal. For this reason, pregnancy rates are also decreasing due to the increasing age of women, especially in IVF trials that have not been applied to PGS. In women under the age of forty, NGS-based PGS normal embryos vary between 40 and 60 percent probability with the results of the analysis, the rate falls below twenty percent in people over the age of 40.
In women over the age of forty, a low pregnancy rate is achieved by transferring an embryo that has not been genetically screened with NGS, while this rate is increased by transferring an embryo that has been diagnosed with NGS and is chromosomally normal.
How Many Days Do NGS Results Come Out?
The embryos that have been biopsied are 5 or 6 until they reach the blastocyst stage. by following it up to the day, only embryos that have not been detected as abnormalities are transferred to the expectant mother's uterus (uterus). The NGS process applied to the embryos is completed within the same day. In this way, treatment planning is quickly directed.
What are the NGS Test Prices?
The information obtained from the results of the NGS test gives a comprehensive information for the IVF process. At this point, NGS, a new generation genetic screening test, has entered our lives as a result of high technology. It is a method that also has many advantages, especially if it provides a quick and wide information about the chromosomal state of the embryo. In addition to the advantages it provides, NGS is a method that also has an extremely low cost. This is a situation that also increases the availability of the test. As the Huma IVF family, we continue to be there for our couples during this exciting process. For all your questions about NGS, you can review our site and contact us for detailed information.
In this article, we have included details about the NGS method. It is important to detect embryos that do not have chromosomal abnormalities, as well as to successfully transfer the embryos obtained in IVF treatments to the uterus. Comprehensive chromosomal screening practices performed by the NGS method play an extremely effective role in detecting chromosomal disorders in embryos and increase the risk of a positive outcome of the process.
