Internal Medicine
Internal medicine is a branch of medicine that diagnoses diseases of internal organs and plans non-surgical treatments.
In our Internal Medicine branch, which is the department that carries out the diagnosis and treatment of the structure and function of the internal organ systems of adult patients, and the diagnosis and treatment of diseases occurring in these organs, in addition to the early diagnosis of diseases, the patient's awareness about how to prevent diseases, the stages to be experienced in the treatment process of existing diseases and, if necessary, referral to different units are made.
Policlinic examinations, inpatient diagnosis, follow-up and treatments, emergency services, pre- and post-surgical patient evaluations, consultation services with other branches and Check-Up services are offered in the field of Internal Medicine with its expert and experienced physician staff.
In Our Internal Diseases (Internal Medicine) Department
• Upper and lower respiratory tract diseases
• Infectious Diseases
• Hypertension
• Stomach and intestinal system diseases
• Kidney diseases
• Heart and Lung and Liver diseases
• Thyroid diseases
• Diabetes disease
• Rheumatic diseases
• Insulin resistance and obesity treatment
• Hematological diseases
• Rheumatological Diseases and Vasculitides
• Oncological Diseases
• Treatments for Internal Medicine Check-Up Programs are implemented.
Ear, Nose, Throat
Ear Nose Throat
In our Ear Nose and Throat Polyclinic, ear diseases such as ear infections, hearing loss, balance disorders and tinnitus, nasal congestion, nasal discharge, olfactory disorders, sinusitis, nasal diseases such as allergic rhinitis, throat diseases such as pharyngitis, tonsillitis, other rare diseases of the mouth and throat ; In addition to hoarseness, dysphagia and speech disorders, cancer diagnosis and treatment of the neck are performed. Our ENT polyclinic is equipped with devices and equipment that allow endoscopic examinations in addition to classical examination tools.
Nose Aesthetics (Rhinoplasty)
Rhinoplasty is an aesthetic operation performed to correct or reconstruct the appearance of the nose. Apart from visual purposes, rhinoplasty is also performed to eliminate structural defects that cause breathing problems. It is also a frequently performed surgery in the treatment of nasal fractures.
The size of the nose, shape and angle of the nose can be changed with Rhinoplasty (nose aesthetics), which is the most preferred operation among aesthetic surgeries and is performed to create a beautiful nose that is compatible with the face and liked by the person himself and his surroundings.
In which cases is rhinoplasty necessary?
• If the patient has aesthetic concerns
• If there are breathing problems due to various functional disorders
• In sinus problems
• In nasal fractures
• In case of cleft lip (with other operations)
• In severe facial burns
How Is Rhinoplasty Performed?
With the first examination to be performed by the surgeon, the patient's complaints, the desired visual changes and whether they are suitable for the nose or face structure are evaluated by sharing ideas between the doctor and the patient. With a detailed examination, it can be determined whether there is any problem in the nose that may prevent the rhinoplasty operation. In the absence of a structural problem, general health checks should also be carried out, and the presence of conditions that may interfere with the surgical operation, such as bleeding diseases, should be investigated. It is very important for the doctor and the patient to establish a good communication with the patient in terms of the shape changes to be made in the patients who are determined to be suitable for the operation, and to explain the patient's expectations to the doctor in a good way. The planning phase is completed by taking photographs of the nose from various angles.
When the day of the operation comes, general anesthesia is usually applied depending on the type of surgery. The duration of the operation also varies according to the procedures to be performed. On average, a rhinoplasty operation is expected to take approximately 1.5-2 hours. After the operation, which is performed by choosing the most suitable method for the patient, open or closed methods, the patients are discharged after being kept under observation for a certain period of time.
How long does the recovery process take in rhinoplasty?
After the rhinoplasty operation, it is of great importance to preserve the shape of the nose and the operation area in order to be successful in the treatment applications performed on the nose. Therefore, any trauma that will adversely affect the shape of the nose should be avoided. Apart from trauma, it is extremely important not to use heavy glasses, not to lie on your side or to apply pressure to the nose area for a period of time. After the surgery, resting adequately, especially for the first two or three days, and avoiding strenuous activities for a week will accelerate the healing process. In addition, medications prescribed by the physician should be used regularly. The control examinations given should not be interrupted, and if there is a dressing suggestion, they should be done regularly.
Today, rhinoplasty surgery gives extremely successful results thanks to the advanced techniques applied. Success in rhinoplasty means a nose that is both visually pleasing to the patient and performing its functions in a healthy way.
Who is suitable for Eyelid Aesthetics (Blepharoplasty)?
Eyelid aesthetics are mostly performed by individuals over the age of 35. It is possible for anyone with a medical need to have it done at any age. One of the first structures to show aging on the human face is the upper eyelid. Eyelid aesthetics (blepharoplasty) surgery cannot stop the ongoing aging of the eyelids; but the tired appearance on the face can be stopped for about 10 years.
How is upper eyelid aesthetics performed?
Upper eyelid aesthetics (blepharoplasty) or droopy eyelid surgery is the process of removing excess skin and fat tissue from the area due to the loss of tension in the skin. The surgical scar does not attract much attention as it will remain on the upper eyelid and will be open during the day. However, in order to avoid the scar, an incision is made from the eyelid fold line and aesthetic stitches are applied. Of course, this deformation of the skin does not occur only on the eyelid, so it gives better cosmetic results when applied together with forehead lift and eyebrow lifting operations.
In addition, interventions such as almond eye aesthetics along with upper eyelid aesthetics (blepharoplasty) are frequently preferred by patients.
How is lower eyelid aesthetics performed?
The fat pads located on the cheekbones atrophy (weak) with the effect of gravity along with the aging process. This causes signs of aging in the form of slumping or edema under the lower eyelid and prominent smile lines around the mouth. The lower eyelid should be evaluated by your physician and checked for bagging and sagging. The form of treatment should be evaluated. If surgery is required, the specialist physician should initiate the planning and process. In lower eyelid aesthetics, the surgical incision is made just below the eyelashes. The skin is lifted and the fat packets are removed. If the under-eye sunkenness continues after the surgery, an under-eye fat injection may be required after recovery.
How long does it take for Eyelid Aesthetics (Blepharoplasty) surgery and post-operative recovery?
After Eyelid Aesthetic Surgery, patients do not have serious pain. Movement is allowed, provided that it is nourished and not heavy. The patient, who is discharged on the same day, is evaluated again the next day and 5 days later. Stitches are often dissolving stitches. However, when necessary, the stitches are removed painlessly without waiting for them to dissolve. After the 5th day, it is allowed to shower and return to normal life. In order to reduce scars in Eyelid Aesthetics, scar reducing creams are sometimes recommended to patients.
WHAT IS SECONDARY INFERTILITY?
In some cases, it is not enough if only the reproductive system is healthy for pregnancy to occur. Along with the reproductive system, it is extremely important for the pregnancy process that many factors work in harmony with each other. Depending on the factors that affect the process, pregnancy may not occur in people. This condition can also be observed if the person has already become pregnant or had a healthy birth.
Infertility, which occurs as a result of a couple having regular sexual intercourse for 12 months and not being able to get pregnant even though they are not using a method of protection, can be seen in two different ways. Never before pregnancy occurs when primary infertility; a live birth or not, regardless of if at least one pregnancy occurred, secondary (secondary) infertility is defined as.
You can continue reading our article about what is secondary infertility, what are its causes, important risk factors and treatment topics.
Causes of Secondary Infertility
Secondary infertility can occur due to both of the couples. The causes of secondary male infertility; the presence of varicose veins in sperm vessels, known as varicocele, infections, traumas and testicular tumors can be listed in the form of. The causes of secondary infertility in women are causes such as differences in ovulation patterns, damage or blockage of the tubes, deterioration of the structure of the uterus, and cervical and cervical cancer, especially as age progresses.
Autoimmune diseases and sexually transmitted diseases are also among the causes dec lead to secondary infertility.
In order to determine which of the many factors considered to cause the development of secondary infertility in people and to make appropriate planning, the couple should consult a specialist physician.
Risk Factors for Secondary Infertility
One of the most curious points about secondary infertility is the risk factors of secondary infertility. Many risk factors can cause the development of secondary infertility in people. These factors;
• Progression of age
• Different disorders such as polycystic ovary syndrome
* Excess weight
• Previous miscarriages
* Stress
* Alcohol, smoking and substance use
It can be sorted as follows. Along with all this, various factors that may differ from person to person can also lead to the development of secondary infertility in people.
Treatment of Secondary Infertility
The causes of secondary infertility, which are an obstacle to a person's conception, can be studied in an extremely wide range. For this reason, first of all, the points that prevent a person from becoming pregnant should be determined by taking into account different factors and an appropriate treatment plan should be developed accordingly. As a result of the evaluations made by taking the patient's history, vaccination and IVF treatments may be recommended to support conception. In order to determine the condition, specific infertility tests can be administered to people after a physical and pelvic examination. The ovulation test and other hormone tests are some of them.
As Huma IVF center, we continue to be with you in this process with our expert staff. For all the questions you have in mind, you can contact us by checking out our experts on our website.
WHAT IS THE SPERMIOGRAM TEST FOR ANALYSIS OF SPERM CELL?
Parents who want to have children generally prefer the most common in vitro fertilization treatment. Before this treatment, both mother-to-be and father-to-be go through many tests. Father-to-be passed; The first of the tests to test for infertility or other problems is the sperm test, also known as the spermiogram test. What is the spermiogram test for the analysis of the sperm cell? How is spermiogram done? What do spermiogram test results mean? We will answer all these questions for you in detail below. We recommend that you continue reading our article to have detailed information about the sperm test.
What is a test (spermiogram)?
Sperm test done to men; It is a test to determine sperm health, sperm count, and whether the sperm are moving correctly in the channels. As a result of the sperm test, if the sperm shape is normal and there is a sufficient number of sperm, it is concluded that your reproductive ability is high. However, in some cases, men may have low sperm count or the ability to reproduce despite having abnormal semen. That's why doctors order a second test for the accuracy of the results. If your results are normal in your first sperm test, you give the other test and if it is normal, these two normal tests show that you do not have an infertility problem. If there are different conditions, your doctor may order other tests.
If there is no semen or sperm as a result of the sperm test, this may indicate that your ducts are blocked. If this is the case, your doctor will plan different surgeries to open the channels.
Issues and Precautions to Consider While Giving Sperm Sample
There are important points to be considered before giving the sperm sample and while giving the sperm sample. Among the things to be considered before giving a sperm sample, we can count that "men should abstain from sexual intercourse for 3 days". Fasting for 3 to 5 days is sufficient. These numbers are important because if you fast for less than 3 days, the sperm count may be low as a result of the sperm test. For this reason, we can say that fasting between 3 and 5 days is sufficient. It is possible to list the issues to be considered while giving a sperm sample as follows;
· Storing the sample in a sterile environment: It is important to protect your sample from the outside environment for a healthy and accurate spermiogram test result. If a sterile environment is not provided, the test result may be inaccurate. Therefore, do not put your hands, especially sample containers, etc. It is important that you keep it as sterile as possible.
· Protecting the delivered sperm from heat: Another important point is to keep your sample away from extreme temperature changes after ejaculation. Because these extreme temperature changes negatively affect spermatozoa. Ideal temperatures for the sample cup should be between 20°C and 37°C.
· Sperm volume, amount: Volume is extremely important in the sperm test. Your sperm volume is expected to be at least 1.5 ml. The reason why you cannot reach the lower limit of 1.5 ml may be external discharge during ejaculation. It is important to be careful about this.
· Use of lubricating foreign substances during the sperm test: It is important not to use any lubricant during the sperm test because these substances seriously affect the sperm parameters. External factors with such an impact can lead to wrong conclusions.
How is the Sperm Test Done?
For the sperm test, you must first be at the IVF center or hospital. There are rooms specially prepared for men in hospitals or IVF centers. In these rooms, men give their sperm in a special container. For the effectiveness of the sperm test, the sperm sample is immediately delivered to the laboratory. The sperm sample given in the laboratory is subjected to many processes and the best quality sperms are selected. The purpose of the procedures is to examine the sperm count, motility and shape in the semen and to reach quality sperm as a result.
Apart from the hospital, sperm samples can be placed in a container and brought to the hospital in the home environment. However, this is highly not recommended. Even if this is accepted, the sperm samples should be brought to the hospital and delivered within half an hour.
Issues and Precautions to Consider When Analyzing Sperm Sample
For the sperm test, you must first be at the IVF center or hospital. There are rooms specially prepared for men in hospitals or IVF centers. In these rooms, men give their sperm in a special container. For the effectiveness of the sperm test, the sperm sample is immediately delivered to the laboratory. The sperm sample given in the laboratory is subjected to many processes and the best quality sperms are selected. The purpose of the procedures is to examine the sperm count, motility and shape in the semen and to reach quality sperm as a result.
Apart from the hospital, sperm samples can be placed in a container and brought to the hospital in the home environment. However, this is highly not recommended. Even if this is accepted, the sperm samples should be brought to the hospital and delivered within half an hour.
Issues and Precautions to Consider When Analyzing Sperm Sample
After the sperm test is given by the prospective fathers, it is examined in the laboratory environment. This examination takes approximately 1-2 hours and after the first hour, active results begin to be obtained. However, sometimes different situations can be encountered. For example, the test is given, but no sperm can be seen when looked at. In these cases, sperm are taken again and centrifuged. When faced with such a situation, the time may be extended. If there is no additional test to be done, the test results are immediately available in an average of 1-1.5 hours.
What Do Sperm Test Results Mean?
Sperm test results can be evaluated in many ways. Sperm analysis evaluates the sperm by analyzing it from various aspects. We can list these analyzes as follows:
· Sperm count and density:
Sperm count describes the number of sperm in 1 ml of semen. The World Health Organization advocates that a normal sperm count should be at least 15 million per ml or at least 39 million per sample. Having fewer sperm than these numbers indicates a low sperm count.
· Sperm morphology:
Non-abnormal sperm have a long tail and oval head. Morphology refers to the size and shape of the sperm a person has. Sperm that do not have a normal size or are weak in shape have difficulty reaching the egg and fertilization.
· Sperm motility:
The ability of sperm to move efficiently is one of the most important factors for fertilization.
· PH level of sperm:
When the pH level is too high or too low, it can affect the health of sperm and its ability to pass through the female reproductive tract.
Apart from these, sperm health is examined by looking at many factors such as semen volume, liquefaction, and seminal fructose levels while performing the sperm test. After examining all factors in detail, the results are examined and reported to the patient.
What is the Sperm Test Result of a Healthy Individual?
Low sperm count can have many different causes. The first reason is smoking addiction. Smoking addiction is one of the important factors that reduce the sperm count. In addition to smoking, alcohol and drug addiction also affect sperm count. Sperm count can also be adversely affected when there is a deficiency in hormones, depending on the clogged ducts.
Hormones are one of the important factors for reproduction on their own. Since the deficiency in reproductive hormones directly affects sperm production, it increases the possibility of encountering problems in reproduction. Apart from these, mistakes made by couples who want to have children also affect the sperm count. Using natural products unconsciously and continuing to use them uncontrollably, without knowing the limit, does harm to the person instead of providing benefits. Long-term treatment and drugs used during the treatment also affect the sperm count.
IMSI in Sperm Selection
The IMSI (Intracytoplasmic Morpholgically Selected Sperm Injection) method is the magnification and examination of even the smallest cells using special microscopes. In the past, in the microinjection procedures applied in IVF treatments, living sperm cells could be enlarged up to 400 times. However, with IMSI, sperm can now be enlarged between 6000 and 8000 times. It is possible to examine and detect in detail the disorders called "vacuoles" that indicate the intracellular structures of the sperm and their genetic damage.
The IMSI technique is an extremely useful method. Selected sperm injection; It allows advanced morphological analysis of sperm without damaging the living sperm cell. Sperm with the highest fertilization ability are selected and a high chance of fertilization between 20% and 40% can be obtained with the applied microinjection application.
Precautions to be Considered for Sperm Quality
Couples who want to have children should pay attention to egg and sperm health and be careful in this regard. There are many factors that affect sperm quality, such as those that affect egg quality. One of these factors is undoubtedly a healthy diet. A healthy diet is extremely important for every organ in the body, of course also in sperm health.
In addition, exercise is very important in making you more vigorous and increasing your body's stamina and activity. Regular exercise will make you recover in a short time and will positively affect both your mental and physical health. Alcohol and smoking are substances that affect reproductive cells and should be avoided. This is a proven fact as a result of research. If we gather all these under one title, we can say that one should take care of his own health. Nutrition, avoiding alcohol, smoking, exercising regularly will first affect your health and therefore your sperm quality.
This process, which is sensitive and special for couples who want to have a child, is extremely important for them. In this process, prospective parents experience excitement on the one hand and a lot of stress on the other. Hüma IVF Center, which understands the emotions experienced best and does not spare its support by being by their side throughout the process, is always ready to accompany you.
What is infertility, what are its symptoms, what kind of treatment method is applied?
What is infertility, what are its symptoms, what kind of treatment method is applied?
Infertility, as it is called in the medical literature, is one of the most important health problems affecting millions of people around the world. In addition to being a health problem that can be seen in women and men, today the number of couples who cannot have children is quite high. According to researches, 10-15% of couples who have unprotected sexual intercourse for a year cannot have a child.
In our article, about infertility, one of the most important health problems in the world; We will try to give short answers about what is infertility, what are the symptoms of infertility and how to apply the treatment method.
What is infertility?
According to the definition of the World Health Organization, infertility; “Failure to conceive within one year of a sexually active couple who had unprotected intercourse without using contraception.” is the status. In other words, in order to be able to talk about infertility exactly, couples must have unprotected intercourse for one year and be unable to conceive. Infertility is one of the important health problems affecting 25% of the world population. In the researches, it can be seen depending on the woman or the man.
What are the symptoms of infertility?
The most important sign of infertility for both men and women is the inability to get pregnant despite having unprotected sexual intercourse for one year. However, some symptoms seen in men and women can be seen as a sign of infertility and an examination may be required accordingly.
infertility in women;
- Imbalances in the menstrual cycle can be considered as a symptom. If you have periods longer than 35 days or shorter than 21 days, you should definitely see a specialist.
- If you are in your 30s and younger, it is expected to get pregnant within 1 year.
- If you are in your 35s and 40s, pregnancy is expected within 6 months. If pregnancy does not occur within 6 months, it is useful to see a doctor.
Infertility in men;
- Sexual dysfunctions are considered a sign of infertility. Example; impotence, ejaculation, such as strain.
- Pain, swelling or a lump in the testicle area during sexual intercourse may also be a sign of infertility.
- Infertility in men can often be caused by hormonal disorders.
Although all these symptoms are not exactly the cause of infertility, they are among the factors affecting it and may be symptoms of infertility.
What kind of treatment method is applied in infertility?
There can be many different reasons for the occurrence of infertility. Therefore, first of all, the causes of infertility are investigated. Different treatment methods are tried according to the detected cause. Some of the treatment methods applied are as follows;
- IVF Treatment
- Vaccination
- Microinjection
In vitro fertilization is one of the most well-known and most preferred and effective treatment methods among other treatment methods.
As Hüma IVF Center team, we tried to give information about what is infertility, what are its symptoms and what kind of treatment method is applied in our article. We hope it was useful. You can contact us via our website to get more detailed information about infertility or to ask your questions.
What Is The Importance Of Genital Examination?
Going to the gynecologist can be a scary idea for many women. Even accepting this idea can be stressful for women because genital examination is thought to hurt and the feeling of shame prevents women from going to the gynecologist unless they have to. However, gynecological examination is not painful. It does not pose an ethical problem either. Just because of some perceptions, women are hesitant to go to the gynecologist. However, many diseases that have given symptoms during genital examination can be pre-diagnosed. The vagina is entered with a speculum, then a smear is taken and this sample is sent to the laboratory. Necessary procedures are applied in cases where further examination is required according to the result.
How is Genital Examination Performed?
Genital examination is done by a healthcare professional. The presence of viruses such as HPV can be detected in the gynecological examination. Since detecting the presence of this virus before pregnancy will affect the pregnancy process, genital examination is important for precaution. Examination is essential in the presence of conditions such as vaginal bleeding, pain in the groin, and discharge. The appearance, smell and quality of the discharge are also very important. Genital examination is of great importance as transparent, milky, yellow or brown discharges can each be a sign of different diseases.
What are the Points to Consider?
The necessity of vaginal examination in case of menstrual irregularity, determining a contraceptive method, cervical infections, and pregnancy is indisputable. It can be life-saving for women not to be afraid of genital examination and to go to a gynecologist for diagnosis. Genital examination is of great importance in terms of early diagnosis in very serious diseases such as endometrial cancers, ovarian ca, ovarian cysts, and cervical cancer. Regardless of what, when they see a disease symptom in themselves, it is important not to infect other reproductive organs, so they should consult an obstetrician. While taking anamnesis, they should tell their stories clearly and do their best to regain their health.
HOW TO UNDERSTAND THAT INSEMINATION WAS SUCCESSFUL?
Insemination treatment is a method of selecting the sperm that is the highest quality of the sperm taken from the expectant father during the ovulation period, that is, during the period when the probability of conception of the expectant mother is the highest, and then putting it into the womb of the expectant mother. A state of fertilization that has been tried many times by natural means, but no successful results have been obtained, thanks to vaccination treatment, sperm and egg dec easily combined and fertilized. So, how will expectant parents understand this situation when Insemination gives a successful result? We will answer this question and give you more detailed information about Insemination treatment. We wish you a pleasant reading in advance.
What is Insemination?
Insemination is a treatment applied by people who want to become parents but have not been able to achieve this condition by natural means. This treatment, which is performed before starting IVF treatment, is aimed at increasing the chances of pregnancy. Insemination takes place exactly as follows;
· Several necessary tests are applied to prospective parents before.
· Male sperm is taken and the best quality sperm is selected by special procedures.
* Spermatozoa are released into the uterus when the woman's eggs are laid. Here this process is known as the vaccination process.
The vaccination method is a method used in cases where the man's sperm count or mobility is low, when there are problems with the excretion of semen during intercourse, when the woman's cervix is narrow. The cause of infertility cannot be explained in any way.
To Whom Is Insemination Therapy Prescribed?
“Who is the Insemination method applied to?"we can explain the question as follows; It is a form of treatment applied to expectant parents who want to have children, but for various reasons some kind of pregnancy condition cannot be created. For the implementation of this treatment, the man or woman must have some problems that he is experiencing. We can list the problems encountered as follows:
· If there is a lack of sperm count and mobility in a man,
· If there is a problem of unexplained infertility (infertility)
· If the woman has ovulation problems and therefore pregnancy could not be done with egg tracking
· It can be applied in couples who want to accelerate the possibility of pregnancy due to social reasons experienced by couples.
What is the Success Rate of Insemination?
With the development of technology in the medical field and the scientific studies conducted, the success rate of Insemination treatment is quite high. And every day these treatments are being enriched with a new way and it is aimed to increase the success rate of Insemination to the highest level.
When Do the Symptoms of Pregnancy Begin With the Success of Insemination?
There is no difference between the occurrence of pregnancy with Insemination and the occurrence of pregnancy by natural means and the appearance of symptoms in terms of the occurrence of pregnancy Dec In other words, expectant mothers are 3rd of pregnancy, as in naturally occurring pregnancies. from the week she begins to experience signs of pregnancy. These symptoms can be considered as complaints such as dizziness, weakness, nausea and vomiting that occur in the morning. Expectant mothers who have these symptoms can find out if they are pregnant by taking a pregnancy test. 12-14 after Insemination to see if pregnancy has occurred. on the day, the Beta HCG hormone is checked in the blood and it is understood whether pregnancy exists or not. If the pregnancy result is positive, you will need to contact your doctor and undergo an examination to keep it under control. After this examination, a clearer result will be obtained by looking at it with ultrasound and it will be determined whether there is a pregnancy or not.
After Insemination, expectant parents should continue their normal lifestyle. They do not need to change anything in their lives with the introduction of Insemination therapy. In this process, they should only take care of regular and balanced nutrition and protect themselves in the best way. We have shared all the details of the vaccination method with you in this article. If you also want to become a parent and are looking for various treatment methods for this, you can check out our page.
WHAT IS COMPREHENSIVE CHROMOSOME SCREENING (NGS)?
IVF treatments are supported by a wide range of tests and analyzes to get a healthy result. With the help of these tests, problems that may occur before and after pregnancy are also detected and planning is carried out in this direction. NGS, a genetic analysis technology that allows comprehensive chromosome screening to be performed in embryos, is a test that gives extremely effective results as technological developments gain momentum. With NGS, embryos are scanned quickly and effectively, and genetic problems at the chromosome level are detected before pregnancy. The aim of this method is to select a healthy embryo by performing genetic analysis on embryos before the transfer process and to increase the chances of a healthy pregnancy. You can continue reading our article for the details of the NGS test.
What is Comprehensive Chromosome Screening (NGS)?
It is extremely important that the embryos obtained in IVF treatments are successfully transferred to the uterus. But in some cases, pregnancy may not be achieved. One of the most important reasons why a healthy pregnancy cannot be achieved despite embryo transfer in treatment has been identified as chromosome disorders that occur in embryos. In order to achieve a healthy and successful result in IVF treatments, it is necessary to analyze the embryos in detail and detect chromosomal abnormalities. Previously, the multidimensional and complex structure of chromosomes would have made multiple tests necessary. While this situation is quite time consuming and costly, the NGS (Next Generation Sequencing) test appears as a result of the developing technology today. The NGS method is a newly developed genetic analysis technology that allows comprehensive chromosome screening of embryos. The NGS method allows all embryos to be screened within a short period of time. With NGS, which offers a quick and detailed scan, chromosome-related problems are diagnosed before pregnancy. All 24 chromosomes are scanned with the NGS test.
Comprehensive chromosomal screening practices performed by the NGS method play an extremely important role in diagnosing disorders and have an effect on facilitating healthy outcomes in IVF treatments.
What are the Features of the NGS Technique?
Chromosomal abnormalities are determined by screening with the NGS method. Embryos containing more than two or more cell communities with different chromosomal structures are called “mosaic embryos”. Mosaic embryos are detected more easily with the NGS technique. After these chromosomal abnormalities detected by the NGS test are detected accurately and in detail, the process is advanced by including them in the treatment planning. Compared to the different PGD methods used to date and known, the NGS method provides a high-intensity scanning area, allowing you to detect even some genetic disorders, as well as numerical changes occurring in chromosomes.
What Genetic Defects Can Be Detected with NGS-Based PGS?
Embryos obtained in IVF treatment are evaluated according to various criteria in terms of the characteristics they have, and a healthy result is sought by ensuring the transfer of the embryo with the best developmental characteristics to the uterus. Examination of the developmental characteristics of the embryo under a microscope by classical methods does not give a clear information about the chromosomal state of the embryo. This information is only reached by performing a genetic screening with PGS. Even if the embryos have a good quality structure, they can contain various chromosomal problems, and this can also lead to problems such as early miscarriages, some structural disorders in the developing fetus, or the embryo does not hold on to the uterus. The main purpose of using the PGS method, which is an NGS-based method, is to increase the adhesion of the embryo to the uterus, which is found to have a chromosomally normal structure, to reduce the likelihood of miscarriage that may occur later, and as a result, to increase the likelihood of couples having healthy babies. The NGS-based PGS operation is performed by embryologists who have the necessary education and experience in this regard. The process takes a short time and does not cause any harm to the embryo. The PGS process begins by combining the egg taken from the expectant mother and the sperm taken from the expectant father outside the body. 5. Development of embryos from formed embryos. or 6. on the day when the blastocyst is at the stage, several cells are taken by biopsy without damaging the embryo. These received cells are sent to the genetic laboratory for a scan of 24 chromosomes, while the embryos are frozen. At this point, it is extremely important that the procedure is performed by a qualified embryologist so that the embryo does not get damaged. At the end of this examination, the embryo or embryos whose genetic structure has been determined to be healthy are transferred after completion of intrauterine preparation and pregnancy results that reach higher rates are obtained, especially.
To summarize briefly; NGS-based PGS is a genetic screening method and can be used to detect numerical and structural imbalances in chromosomes. However, single gene diseases, especially those with familial transmission, cannot be detected with the PGS method.
Who are the Groups of Patients Who Can Be Administered NGS?
The benefits of the NGS method, which is a new generation genetic analysis technology, also raises the question of which patient groups this technique can be applied to. Before answering this question, we can state that the intended point of the NGS method is to be able to detect numerical and structural changes in chromosomes. Therefore, we can address the question of which people have these changes more often for groups of patients who can be administered NGS. Groups of patients for whom NGS can be applied can be listed as follows;
· In cases of repeated miscarriage,
· in expectant mothers over the age of 38,
· In severe male infertility,
* In cases of infertility, the cause of which is unknown,
· It is applied in cycles of continuous self-recurring treatment failures.
The NGS method, which is a rapidly developing field, is actively used in many countries today due to its possibilities and facilitating and accelerating effects for the process.
What are the Advantages of Preimplantastone Genetic Screening with NGS?
NGS, a new genetic examination method used to screen for 24 chromosomes in embryos, provides the opportunity to examine and sequence the entire human genome both numerically and structurally in a short period of time, such as a single day. It offers us a revolutionary technology in this aspect. The improved NGS method can detect mosaic embryos better than other PGD methods. The main advantages of Preimplantastone Genetic Screening with NGS are that it allows you to quickly scan a large area of genes, both numerically and structurally. In addition to scanning gene fields numerically and structurally, the NGS method also has advantages such as obtaining a more accurate result with a low margin of error, achieving faster results, and having a lower cost. With this method, 24 chromosome screening can also be performed simultaneously with the study of single gene diseases and HLA typing.
Does NGS Damage the Embryo?
IVF treatments are an extremely exciting period for couples. During this period, in order to obtain a healthy result, various tests are applied to the embryos obtained to determine the success rate. In some cases, couples may have a high risk of genetically abnormal embryo development. Advanced maternal age is one of these conditions. Embryos that are not genetically normal are not suitable for transfer. In order to be able to determine the chromosomal status of embryos and to obtain a healthy result, process planning is carried out in the light of the NGS result. Another confusing situation for couples at this point is whether NGS causes any damage to the embryo during the application phase. Doctors who specialize in their field and NGS performed under appropriate conditions do not pose a danger risk to the embryo. At this point, managing and planning the process in accordance with the needs with a reliable specialist and institution will also be an extremely important step.
Does Pregnancy Always Occur With a Smoothly Detected Embryo?
After the tests and examinations, embryos that do not carry any genetic abnormalities are placed in the uterus. The probability of the occurrence of pregnancy after this procedure develops due to various factors. These factors;
· Women's age
· The amount of ovarian reserve of the woman
* Sperm quality
· Embryo quality
· Ensuring a proper intrauterine environment
· The presence of hydrosalpinx
· Conditions encountered during embryo transfer
it can be sorted as follows. All these factors are among the dec that affect the occurrence of pregnancy. From this point of view, it is impossible to say that pregnancy always occurs with an embryo that is detected without problems.
Studies have shown that age-related embryos are less likely to be chromosomally normal. For this reason, pregnancy rates are also decreasing due to the increasing age of women, especially in IVF trials that have not been applied to PGS. In women under the age of forty, NGS-based PGS normal embryos vary between 40 and 60 percent probability with the results of the analysis, the rate falls below twenty percent in people over the age of 40.
In women over the age of forty, a low pregnancy rate is achieved by transferring an embryo that has not been genetically screened with NGS, while this rate is increased by transferring an embryo that has been diagnosed with NGS and is chromosomally normal.
How Many Days Do NGS Results Come Out?
The embryos that have been biopsied are 5 or 6 until they reach the blastocyst stage. by following it up to the day, only embryos that have not been detected as abnormalities are transferred to the expectant mother's uterus (uterus). The NGS process applied to the embryos is completed within the same day. In this way, treatment planning is quickly directed.
What are the NGS Test Prices?
The information obtained from the results of the NGS test gives a comprehensive information for the IVF process. At this point, NGS, a new generation genetic screening test, has entered our lives as a result of high technology. It is a method that also has many advantages, especially if it provides a quick and wide information about the chromosomal state of the embryo. In addition to the advantages it provides, NGS is a method that also has an extremely low cost. This is a situation that also increases the availability of the test. As the Huma IVF family, we continue to be there for our couples during this exciting process. For all your questions about NGS, you can review our site and contact us for detailed information.
In this article, we have included details about the NGS method. It is important to detect embryos that do not have chromosomal abnormalities, as well as to successfully transfer the embryos obtained in IVF treatments to the uterus. Comprehensive chromosomal screening practices performed by the NGS method play an extremely effective role in detecting chromosomal disorders in embryos and increase the risk of a positive outcome of the process.
