TESE - TESA Practices
Micro TESE is a painless procedure performed under anesthesia. The aim here is to enlarge the tissue under the microscope and remove the tissues with a high probability of containing sperm. Therefore, while the probability of finding sperm increases in theory, the damage to the testis decreases as less tissue is taken. Tissue samples taken are subjected to a series of processes and living sperm cells are separated. While these cells are used in the microinjection process, sperm are stored in other observed tissues for use in different experiments. Points to consider before micro-TESE You should not eat or drink anything (including water) for at least 6 hours before the operation. · Clean the operation area with a razor blade. Take a bath.
Bring loose
trousers or sweatpants with you as pressure on the testicles will cause pain after the operation. You will be discharged 1-2 hours after the operation. Points to consider after micro TESE Liquid food intake can be started within 3 hours after the
operation. You can take a bath on the 5th day after the operation. · Do not have sexual intercourse for 1 week. If you have pain, you can use painkillers. If you experience redness, swelling or bleeding at the operation site, inform your doctor.
Since
self-dissolving sutures are used during Micro TESE, there is no suture removal process. The stitches will dissolve by themselves in 7-10 days. Risks As a result of micro TESE, viable sperm cells may not be obtained. This risk depends on the underlying cause. The chance of finding sperm in a patient with obstruction in the sperm ducts; higher than the patient with hormonal or genetic problems. Postoperatively, infection and bleeding may occur at the operation site.
PGD (Pre-implantation Genetic Diagnostic)
PREIMPLANTATION GENETIC DIAGNOSIS
In recent years, developments in genetics allow genetic analysis to be carried out on embryos developed in vitro by in vitro fertilization ethods and the placement of selected healthy embryos in the uterus of the mother before pregnancy occurs. This method is called pre- regnancy genetic diagnosis (Preimplantation Genetic Diagnosis-PGD).
One of the most important application areas of the PGT technique embryos that do not have a genetic disease but may not have a genetic disorder in their chromosomes.
These disorders are more common in women of advanced age (35 years and older). This situation may result in infertility as it both reduces the chance of attachment of the embryo (implantation) and may cause unwanted abortions. As a matter of fact, 40 out of every 100 pregnancies in women aged 39 and over have problems that occur due to a numerical chromosomal disorder
The aim of PGD is to increase implantation rates, reduce spontaneous abortions and increase healthy baby birth rates by selecting hromosomally normal embryos. Indeed, the miscarriage rate, which can reach up to 23 percent in normal pregnancy due to chromosomal disorders, may decrease to 9 percent after PGD.
Pre-pregnancy genetic diagnosis is performed by taking 1 or 2 cells from embryos developed as a result of fertilization of egg and sperm cells obtained from mother and father candidates in laboratory environment. Special methods called Fluorescence In Situ Hybridization (FISH), Microarray-based comparative genomic hybridization (aCGH) or Polymerase Chain Reaction (PCR) are used for genetic diagnosis. Diagnosis of numerical chromosomal disorders such as monosomy or trisomy (Down syndrome and other trisomies) and single gene diseases (such as hemophilia, Mediterranean anemia, cystic fibrosis, muscular dystrophies) in the baby to be born is possible with PGD. Thus, healthy babies are born by transferring disease-free, healthy embryos to the expectant mother.
DIAGNOSIS BEFORE PREGNANCY
- In couples with a genetic or hereditary disease carrier,
- In couples who have a child or children with a previous genetic disease,
- For the purpose of HLA genotyping (tissue typing),
- In the identification of diseases showing genetic predisposition (tendency)
- Women in the advanced age group (37 years and over) who have been accepted for assisted reproductive techniques,
- In couples with recurrent early pregnancy miscarriages,
- In couples who could not achieve pregnancy with assisted reproductive techniques despite multiple applications or who lost their pregnancy due to miscarriage,
- It is applied in cases of chromosomal disorders or genetic diseases associated with severe male infertility.
HOW IS THE PGT TEST DONE?
- Whether the patient is suitable for PGD is evaluated by the reproductive health specialist, genetic counselor and the doctor of the related disease.
- The couple is prepared for the IVF procedure.
- The egg taken from the mother is fertilized in the laboratory with the sperm taken from the father.
- 1-2 blastomere cells are removed from the obtained embryo by biopsy by embryologists
- Cells obtained by biopsy are prepared and tested according to the method to be applied.
- Embryos with genetic diseases or chromosomal disorders are selected and discarded and healthy embryos are transferred to the mothers womb.
Pool Method
Embryo pool technique is the method of freezing the embryos obtained by collecting two or more eggs (OPU) and transferring the accumulated embryos by thawing them together. It is possible to make an embryo pool by collecting eggs multiple times using little medication (seminatural cycle) or without using drugs (natural cycle) and transferring embryos that have reached advanced developmental stages, such as blastocyst stage. This application is recommended for couples with reduced egg reserve or concomitant IVF failures. With the embryo pool method, it will be possible to achieve more treatment with less cost, a higher chance of pregnancy per embryo transfer, and reduce the negative effects of infertility on couples.
How many times can IVF treatment be tried?
IVF treatment, which is preferred by couples who cannot conceive naturally and cannot have children, is a source of hope for couples who cannot have children due to the development of medicine and technology. IVF treatment is the fertilization of male and female reproductive cells outside the body under laboratory conditions. Currently, couples have a 95 percent chance of success with IVF treatments. IVF treatment is one of the most successful methods in the treatment of infertility, the cause of which is not clear, or which cannot be conceived in the most natural ways. If couples do not succeed in their first attempts at IVF treatments, they should not despair and stress immediately. Because there are no restrictions on IVF treatment.
How many times can IVF treatment be tried?
A study conducted on couples undergoing IVF treatment shows that the rate of achieving pregnancy in couples after the first three trials is 95 percent. In addition, no number can be given about the number of treatments in the remaining group. The experts are also 4. or 5. there is an opinion that the chances of IVF success in trials are slightly lower than in the first three trials. The success rate of IVF treatment does not depend on many attempts. Multiple factors, such as the age of the couples, obtaining a quality embryo, affect the success rate of IVF treatment at a critical point.
Is Success Achieved in the First Attempt in IVF?
The chances of pregnancy during the one-month treatment period with the insemination method or ovulation treatments are about 20% or slightly more than the chances of a healthy couple becoming pregnant in a month. These treatments can be tried 3 or 4 times until pregnancy is achieved, but most of the pregnancies are obtained in the first months of treatment. Continuing treatment for more than 4 years will not increase the chances of pregnancy, so you can switch to IVF treatment.
Currently, thanks to newly developed methods and applications, the success rate of in vitro fertilization treatment is gradually increasing, if success is not achieved at the first attempt, repeated attempts can be made. The chance of becoming pregnant in a month with IVF treatments varies depending on age, but on average it is up to 50-60%. Pregnancy rates can increase by more than 90% after 4 applications when more than one treatment is performed in a row. For this reason, the chances of becoming pregnant increase with the number of attempts in couples who do not have a specific problem.
THE PROCESS AFTER FAILED IVF AND FACTORS AFFECTING SUCCESS
IVF treatment; It is the method that offers the highest chance of pregnancy for couples who want to have a baby but cannot conceive naturally. In vitro fertilization method can be applied as a result of unprotected intercourse for more than 1 year, when pregnancy does not occur. Although it is a successful method, it may not always be possible to achieve 100% success in IVF treatments. There are many factors that determine the probability of successful IVF treatment.
What Factors Depends on Success in IVF Treatment?
In IVF treatment, it is aimed to catch pregnancy in the first time, but pregnancy is not possible for every woman at once. Factors affecting the success of IVF treatment include the age of the expectant mother, weight status, problems in the uterus, hydrosalpinx in the tubes, immune system problems, smoking degree, alcohol use rate, and decreased ovarian reserve. With this; Various male-related conditions such as sperm immobility, severe deformities, and absence of sperm in the semen also affect the success rate of IVF treatment. General statistical data can give you information about the success rate in IVF treatment, but it should not be forgotten that every couple is very special and unique. In IVF treatment, your doctor can better determine your individual chances, taking into account your personalized factors.
What are the Risks of IVF Treatment?
As with any treatment, there are some risks in IVF treatment. However, some of these risks, which are likely to be encountered in IVF treatment, are predictable and can be intervened early, although these risks are very rare. We can list these risks as follows: Mild bruising, swelling and pain may occur in the areas where the drugs were injected. Overstimulation of the eggs can result in weight gain, nausea, vomiting and bloating. There may be a risk of ectopic pregnancy. Bleeding may occur during egg collection.
What Should Be Done After Unsuccessful IVF?
Failure of one or more IVF attempts can be extremely challenging, disappointing couples. This situation is extremely natural. One of the most important reasons for a failed IVF treatment is poor embryo quality. Defective and damaged embryos cannot be attached to the uterus after they are transferred to the uterus. However, in some cases, pregnancy may not be achieved despite transferring good quality embryos. Your doctor will evaluate the reasons for the failure of your IVF process in detail to determine what the problem is. These points will be taken into account in future attempts after the problem is determined. Taking a break for at least a month after a failed IVF attempt will also be very beneficial for the process. As developments in the field of medicine increase, it becomes easier to detect and eliminate negative situations. It is important that couples who fail their first IVF attempt should not despair. When conditions are improved, the chances of pregnancy will be higher in subsequent attempts.
WHAT IS EMBRYO GLUE? HOW AND WHO USE IT? IS THE SUCCESS RATE HIGH?
As couples who want to become parents cannot become parents with natural methods, couples resort to some treatments. In vitro fertilization is the first treatment method. And IVF treatment is a very advanced and effective treatment method. Some applications in IVF treatment are important for the positive outcome of the treatment. Embryo glue application, which is one of the important application methods, is a very successful application. Embryo glue is one of the applications without any known risk. As a result of the studies, it was concluded that it did not increase the risk of miscarriage or pregnancy complications. Now we will provide you with detailed information about embryo glue. We wish you pleasant reading.
What is Embryo Adhesive?
Embryo glue, a method used in IVF treatments, is a kind of liquid embryo culture medium enriched with a substance called hyaluronan, in which embryos are left before transfer to the uterus of the expectant mother.
Hyaluronan is a natural carbohydrate found in all tissues in the body. The embryo needs an environment rich in carbohydrates, amino acids and protein in order to develop healthily inside. In addition, embryo glue is also called embryo glue because it reduces the ability of the embryo to move in the uterus.
How and Who Is Embryo Adhesive Used?
Embryo adhesive application is done as follows:
After the embryos are developed in the laboratory for 3-5 days, the most suitable one for embryo transfer is selected.
· The most suitable embryos selected for transfer are taken into the embryo glue.
· Embryos are kept in this environment for about 30 minutes.
· After standing, the embryos are taken from the culture dish and drawn into the catheter (a thin tube).
· The catheter is then passed through the cervix under ultrasound guidance and the embryos are transferred to the uterus.
In expectant mothers who have repeated in vitro fertilization failure using the embryo glue method,
It is used in couples who want to have children over the age of 35, when the quality of the embryo depending on the egg or sperm is not very good.
Is the Success Rate High in Embryo Bonding?
Embryo adhesive is one of the most frequently used applications for the last 10 years in order to increase the chance of success in IVF treatment. Experts were unsure about the effectiveness of embryo glue at first. However, in recent years, the effectiveness of embryo glue has been observed as a result of scientific research. Today, embryo glue is applied by various IVF centers. Hüma IVF Center is one of these centers.
The high concentration of hyaluronan concentrates the embryo glue similar to the tissue of the fluids in the womb, so that better mixing of these fluids minimizes the mobility of the embryo. In addition, hyaluronan acts as a bridge between the embryo and the inner wall of the uterus by binding to the inner wall of the uterus and the molecules on the surface of the embryo. In this way, it helps the embryo to attach to the uterus.
We aimed to give you information on this subject by considering the embryo glue method. We talked about how this method is applied and its success rate.
WHAT IS THE SPERMIOGRAM TEST FOR ANALYSIS OF SPERM CELL?
Parents who want to have children generally prefer the most common in vitro fertilization treatment. Before this treatment, both mother-to-be and father-to-be go through many tests. Father-to-be passed; The first of the tests to test for infertility or other problems is the sperm test, also known as the spermiogram test. What is the spermiogram test for the analysis of the sperm cell? How is spermiogram done? What do spermiogram test results mean? We will answer all these questions for you in detail below. We recommend that you continue reading our article to have detailed information about the sperm test.
What is a test (spermiogram)?
Sperm test done to men; It is a test to determine sperm health, sperm count, and whether the sperm are moving correctly in the channels. As a result of the sperm test, if the sperm shape is normal and there is a sufficient number of sperm, it is concluded that your reproductive ability is high. However, in some cases, men may have low sperm count or the ability to reproduce despite having abnormal semen. That's why doctors order a second test for the accuracy of the results. If your results are normal in your first sperm test, you give the other test and if it is normal, these two normal tests show that you do not have an infertility problem. If there are different conditions, your doctor may order other tests.
If there is no semen or sperm as a result of the sperm test, this may indicate that your ducts are blocked. If this is the case, your doctor will plan different surgeries to open the channels.
Issues and Precautions to Consider While Giving Sperm Sample
There are important points to be considered before giving the sperm sample and while giving the sperm sample. Among the things to be considered before giving a sperm sample, we can count that "men should abstain from sexual intercourse for 3 days". Fasting for 3 to 5 days is sufficient. These numbers are important because if you fast for less than 3 days, the sperm count may be low as a result of the sperm test. For this reason, we can say that fasting between 3 and 5 days is sufficient. It is possible to list the issues to be considered while giving a sperm sample as follows;
· Storing the sample in a sterile environment: It is important to protect your sample from the outside environment for a healthy and accurate spermiogram test result. If a sterile environment is not provided, the test result may be inaccurate. Therefore, do not put your hands, especially sample containers, etc. It is important that you keep it as sterile as possible.
· Protecting the delivered sperm from heat: Another important point is to keep your sample away from extreme temperature changes after ejaculation. Because these extreme temperature changes negatively affect spermatozoa. Ideal temperatures for the sample cup should be between 20°C and 37°C.
· Sperm volume, amount: Volume is extremely important in the sperm test. Your sperm volume is expected to be at least 1.5 ml. The reason why you cannot reach the lower limit of 1.5 ml may be external discharge during ejaculation. It is important to be careful about this.
· Use of lubricating foreign substances during the sperm test: It is important not to use any lubricant during the sperm test because these substances seriously affect the sperm parameters. External factors with such an impact can lead to wrong conclusions.
How is the Sperm Test Done?
For the sperm test, you must first be at the IVF center or hospital. There are rooms specially prepared for men in hospitals or IVF centers. In these rooms, men give their sperm in a special container. For the effectiveness of the sperm test, the sperm sample is immediately delivered to the laboratory. The sperm sample given in the laboratory is subjected to many processes and the best quality sperms are selected. The purpose of the procedures is to examine the sperm count, motility and shape in the semen and to reach quality sperm as a result.
Apart from the hospital, sperm samples can be placed in a container and brought to the hospital in the home environment. However, this is highly not recommended. Even if this is accepted, the sperm samples should be brought to the hospital and delivered within half an hour.
Issues and Precautions to Consider When Analyzing Sperm Sample
For the sperm test, you must first be at the IVF center or hospital. There are rooms specially prepared for men in hospitals or IVF centers. In these rooms, men give their sperm in a special container. For the effectiveness of the sperm test, the sperm sample is immediately delivered to the laboratory. The sperm sample given in the laboratory is subjected to many processes and the best quality sperms are selected. The purpose of the procedures is to examine the sperm count, motility and shape in the semen and to reach quality sperm as a result.
Apart from the hospital, sperm samples can be placed in a container and brought to the hospital in the home environment. However, this is highly not recommended. Even if this is accepted, the sperm samples should be brought to the hospital and delivered within half an hour.
Issues and Precautions to Consider When Analyzing Sperm Sample
After the sperm test is given by the prospective fathers, it is examined in the laboratory environment. This examination takes approximately 1-2 hours and after the first hour, active results begin to be obtained. However, sometimes different situations can be encountered. For example, the test is given, but no sperm can be seen when looked at. In these cases, sperm are taken again and centrifuged. When faced with such a situation, the time may be extended. If there is no additional test to be done, the test results are immediately available in an average of 1-1.5 hours.
What Do Sperm Test Results Mean?
Sperm test results can be evaluated in many ways. Sperm analysis evaluates the sperm by analyzing it from various aspects. We can list these analyzes as follows:
· Sperm count and density:
Sperm count describes the number of sperm in 1 ml of semen. The World Health Organization advocates that a normal sperm count should be at least 15 million per ml or at least 39 million per sample. Having fewer sperm than these numbers indicates a low sperm count.
· Sperm morphology:
Non-abnormal sperm have a long tail and oval head. Morphology refers to the size and shape of the sperm a person has. Sperm that do not have a normal size or are weak in shape have difficulty reaching the egg and fertilization.
· Sperm motility:
The ability of sperm to move efficiently is one of the most important factors for fertilization.
· PH level of sperm:
When the pH level is too high or too low, it can affect the health of sperm and its ability to pass through the female reproductive tract.
Apart from these, sperm health is examined by looking at many factors such as semen volume, liquefaction, and seminal fructose levels while performing the sperm test. After examining all factors in detail, the results are examined and reported to the patient.
What is the Sperm Test Result of a Healthy Individual?
Low sperm count can have many different causes. The first reason is smoking addiction. Smoking addiction is one of the important factors that reduce the sperm count. In addition to smoking, alcohol and drug addiction also affect sperm count. Sperm count can also be adversely affected when there is a deficiency in hormones, depending on the clogged ducts.
Hormones are one of the important factors for reproduction on their own. Since the deficiency in reproductive hormones directly affects sperm production, it increases the possibility of encountering problems in reproduction. Apart from these, mistakes made by couples who want to have children also affect the sperm count. Using natural products unconsciously and continuing to use them uncontrollably, without knowing the limit, does harm to the person instead of providing benefits. Long-term treatment and drugs used during the treatment also affect the sperm count.
IMSI in Sperm Selection
The IMSI (Intracytoplasmic Morpholgically Selected Sperm Injection) method is the magnification and examination of even the smallest cells using special microscopes. In the past, in the microinjection procedures applied in IVF treatments, living sperm cells could be enlarged up to 400 times. However, with IMSI, sperm can now be enlarged between 6000 and 8000 times. It is possible to examine and detect in detail the disorders called "vacuoles" that indicate the intracellular structures of the sperm and their genetic damage.
The IMSI technique is an extremely useful method. Selected sperm injection; It allows advanced morphological analysis of sperm without damaging the living sperm cell. Sperm with the highest fertilization ability are selected and a high chance of fertilization between 20% and 40% can be obtained with the applied microinjection application.
Precautions to be Considered for Sperm Quality
Couples who want to have children should pay attention to egg and sperm health and be careful in this regard. There are many factors that affect sperm quality, such as those that affect egg quality. One of these factors is undoubtedly a healthy diet. A healthy diet is extremely important for every organ in the body, of course also in sperm health.
In addition, exercise is very important in making you more vigorous and increasing your body's stamina and activity. Regular exercise will make you recover in a short time and will positively affect both your mental and physical health. Alcohol and smoking are substances that affect reproductive cells and should be avoided. This is a proven fact as a result of research. If we gather all these under one title, we can say that one should take care of his own health. Nutrition, avoiding alcohol, smoking, exercising regularly will first affect your health and therefore your sperm quality.
This process, which is sensitive and special for couples who want to have a child, is extremely important for them. In this process, prospective parents experience excitement on the one hand and a lot of stress on the other. Hüma IVF Center, which understands the emotions experienced best and does not spare its support by being by their side throughout the process, is always ready to accompany you.
WHAT IS A REDUCED OVER RESERVE (AMH)?
Ovarian reserve, known as the ovary, is a term used to determine the fertilization ability of the ovary to provide egg cells and to determine the probability of a successful pregnancy. With the advancing age of the expectant mother, the number of egg cells obtained from the follicles for pregnancy decreases. decreased ovarian reserve (AMH); It is a condition in which the ovaries begin to lose their normal production capabilities, reducing fertility. Decreased ovarian reserve reduces women's chances of conceiving spontaneously or with treatment. However, it is aimed to minimize the effects of this situation with various methods. The main causes of decreased ovarian reserve can be listed as follows:
· Smoking,
Chronic diseases,
Coffee consumption
Age of the expectant mother,
Genetic abnormalities (X chromosome abnormalities)
Various treatments (such as radiation for cancer)
· Having undergone ovarian surgery.
You can continue reading our article for reduced ovarian reserve and all its details.
How to Identify Decreased Ovarian Reserve?
Decreased ovarian reserve is determined by examining the hormone tests to be performed on the 2nd or 3rd day of the menstrual period of the expectant mother. FSH hormone gives information about the status of ovarian reserves. If the FSH value is higher than 10, it indicates decreased ovarian capacity.
The best indication of the capacity of the ovaries is the vaginal ultrasound. Existing and developing egg structures can be easily detected here. If there are less than six egg structures in the total ovaries, decreased ovarian reserve may be in question.
In summary, decreased ovarian reserve; It can be understood by clinical evaluation of the person, vaginal ultrasound, measurement of AMH hormone and FSH hormone in the blood.
Can a Woman with a Decreased Ovarian Reserve Get Pregnant?
Existing studies show that women with reduced ovarian reserve can become pregnant both spontaneously and with IVF treatment. Although it has been shown that high serum FSH levels in women are associated with low pregnancy rates, it is not sufficient to make a decision based on this alone. Egg cells also regulate their size under the influence of genetic factors. The speed of the aging process of the ovaries varies greatly among women, except for the age factor. In addition to the successful results of endocrine tests and imaging methods in the numerical evaluation of ovarian reserve, their values in determining the chance of pregnancy remain at a limited level.
The chance of conceiving of a woman who is determined to have decreased ovarian reserve with ovarian reserve tests and clinical evaluations by specialist physicians can be increased by applying appropriate ovulation treatment protocols. Patients with reduced ovarian reserve can become mothers with different techniques today. In order to determine these methods, it is important to plan and apply special treatment methods suitable for patients by considering various factors.
How Is Decreased Ovarian Reserve Treated?
Currently, there is no treatment for decreased ovarian reserve that prevents or slows down ovarian aging. In addition, lifestyle changes have an extremely important role in preventing premature aging of the ovaries and in order to ensure the healthy continuation of egg quality, that is, to increase egg reserve and quality. These;
· Eating a balanced and healthy diet,
Doing regular exercise,
Quality and adequate sleep,
Avoiding chemicals, high glycemic index and fast food style foods,
Not to use substances such as cigarettes and alcohol,
· Using antioxidant drugs under the control of a physician.
If you have decreased ovarian reserve and want to have a child according to your required tests and vaginal ultrasound results, it is extremely important to seek in vitro fertilization treatment in the presence of a specialist doctor, without wasting time.
As Hüma IVF Center, we choose the most appropriate treatment method for you, apply it and continue to serve.
WHAT IS BLASTOCYST TRANSFER? WHAT ARE THE ADVANTAGES OF BLASTOCYST TRANSFER?
Blastocyst transfer, which is one of the advanced in vitro fertilization techniques applied today, is a method that offers a much higher chance of pregnancy to couples who want to have children. The blastocyst transfer method, which is a method that minimizes the possibility of multiple pregnancy, which is frequently encountered in IVF treatments, supports families in making their plans to have a child more effectively. The blastocyst is defined as the 5th or 6th day of the egg becoming an embryo. Before transfer, one or two embryos of the highest quality are selected and the transfer is carried out. This method is among the most important processes of IVF treatment. What is blastocyst transfer, what are its advantages and risks? You can continue reading our article, which includes the details of blastocyst transfer with questions.
What is blastocyst transfer?
Blastocyst transfer, which has an extremely important place in the IVF treatment process, is the process of transferring the embryo created in the laboratory environment to the woman on the 5th or 6th development day. Embryos are followed in incubators in the laboratory and when they reach the blastocyst stage, transfer to the uterus is performed. Blastocyst transfer has many positive contributions to the IVF process, such as enabling better quality embryo transfer and reducing the risk of multiple pregnancy.
What are the advantages of blastocyst transfer?
Blastocyst transfer is a method that has been used frequently in recent years, depending on the developing technologies. In the first years of in vitro fertilization treatment, the expected time for transfer was 48 hours, but this period has been extended in parallel with the developments experienced today. In the blastocyst transfer method, embryos with the highest success rate are selected more easily with transfers made after 5 and 6 days. In general, the advantages of blastocyst transfer can be listed as follows;
The chance to achieve better results against recurrent pregnancy failures, thanks to the selection of embryos with better development potential and compatibility with the uterus,
Reducing the possibility of multiple pregnancy by transferring fewer embryos with high viability,
The chance to observe the embryo development more clearly and healthily,
Freezing of embryos at the time when they have the highest developmental power, that is, at the blastocyst stage,
· Allowing different methods to examine embryo viability.
What is the risk of blastocyst transfer?
The condition that can be encountered frequently as a result of blastocyst transfer is the factor of multiple pregnancy. For this reason, some legal restrictions have been imposed on the number of embryos to be transferred in order to be protected from the risks of multiple pregnancy. For our country, this limit has been determined to be a maximum of 2 embryos. By performing 1 or 2 blastocyst transfers in embryo transfer on the 5th day, both the risk of multiple pregnancy is reduced and the chance of pregnancy is increased. The aim of IVF treatment is to achieve a healthy fertilization. In this direction, better quality but less number of embryo transfers will minimize the risks that may be encountered and will facilitate healthy results.
Who is blastocyst transfer suitable for?
Blastocyst transfer can be applied to all couples with a high number of fertilized eggs and good embryo quality on the 2nd day. Since a single embryo can be transferred in the first two attempts under the age of 35, a blastocyst transfer will be made to them, thus preventing multiple pregnancy. In our country, blastocyst transfer is successfully applied and high success rates are achieved. However, the remaining quality embryos after the transfer are successfully frozen with the vitrification method, which is a new and fast freezing technique, giving couples a second chance. You can visit our website for more information and to make an appointment.
HOW TO UNDERSTAND THAT INSEMINATION WAS SUCCESSFUL?
Insemination treatment is a method of selecting the sperm that is the highest quality of the sperm taken from the expectant father during the ovulation period, that is, during the period when the probability of conception of the expectant mother is the highest, and then putting it into the womb of the expectant mother. A state of fertilization that has been tried many times by natural means, but no successful results have been obtained, thanks to vaccination treatment, sperm and egg dec easily combined and fertilized. So, how will expectant parents understand this situation when Insemination gives a successful result? We will answer this question and give you more detailed information about Insemination treatment. We wish you a pleasant reading in advance.
What is Insemination?
Insemination is a treatment applied by people who want to become parents but have not been able to achieve this condition by natural means. This treatment, which is performed before starting IVF treatment, is aimed at increasing the chances of pregnancy. Insemination takes place exactly as follows;
· Several necessary tests are applied to prospective parents before.
· Male sperm is taken and the best quality sperm is selected by special procedures.
* Spermatozoa are released into the uterus when the woman's eggs are laid. Here this process is known as the vaccination process.
The vaccination method is a method used in cases where the man's sperm count or mobility is low, when there are problems with the excretion of semen during intercourse, when the woman's cervix is narrow. The cause of infertility cannot be explained in any way.
To Whom Is Insemination Therapy Prescribed?
“Who is the Insemination method applied to?"we can explain the question as follows; It is a form of treatment applied to expectant parents who want to have children, but for various reasons some kind of pregnancy condition cannot be created. For the implementation of this treatment, the man or woman must have some problems that he is experiencing. We can list the problems encountered as follows:
· If there is a lack of sperm count and mobility in a man,
· If there is a problem of unexplained infertility (infertility)
· If the woman has ovulation problems and therefore pregnancy could not be done with egg tracking
· It can be applied in couples who want to accelerate the possibility of pregnancy due to social reasons experienced by couples.
What is the Success Rate of Insemination?
With the development of technology in the medical field and the scientific studies conducted, the success rate of Insemination treatment is quite high. And every day these treatments are being enriched with a new way and it is aimed to increase the success rate of Insemination to the highest level.
When Do the Symptoms of Pregnancy Begin With the Success of Insemination?
There is no difference between the occurrence of pregnancy with Insemination and the occurrence of pregnancy by natural means and the appearance of symptoms in terms of the occurrence of pregnancy Dec In other words, expectant mothers are 3rd of pregnancy, as in naturally occurring pregnancies. from the week she begins to experience signs of pregnancy. These symptoms can be considered as complaints such as dizziness, weakness, nausea and vomiting that occur in the morning. Expectant mothers who have these symptoms can find out if they are pregnant by taking a pregnancy test. 12-14 after Insemination to see if pregnancy has occurred. on the day, the Beta HCG hormone is checked in the blood and it is understood whether pregnancy exists or not. If the pregnancy result is positive, you will need to contact your doctor and undergo an examination to keep it under control. After this examination, a clearer result will be obtained by looking at it with ultrasound and it will be determined whether there is a pregnancy or not.
After Insemination, expectant parents should continue their normal lifestyle. They do not need to change anything in their lives with the introduction of Insemination therapy. In this process, they should only take care of regular and balanced nutrition and protect themselves in the best way. We have shared all the details of the vaccination method with you in this article. If you also want to become a parent and are looking for various treatment methods for this, you can check out our page.
WHAT IS COMPREHENSIVE CHROMOSOME SCREENING (NGS)?
IVF treatments are supported by a wide range of tests and analyzes to get a healthy result. With the help of these tests, problems that may occur before and after pregnancy are also detected and planning is carried out in this direction. NGS, a genetic analysis technology that allows comprehensive chromosome screening to be performed in embryos, is a test that gives extremely effective results as technological developments gain momentum. With NGS, embryos are scanned quickly and effectively, and genetic problems at the chromosome level are detected before pregnancy. The aim of this method is to select a healthy embryo by performing genetic analysis on embryos before the transfer process and to increase the chances of a healthy pregnancy. You can continue reading our article for the details of the NGS test.
What is Comprehensive Chromosome Screening (NGS)?
It is extremely important that the embryos obtained in IVF treatments are successfully transferred to the uterus. But in some cases, pregnancy may not be achieved. One of the most important reasons why a healthy pregnancy cannot be achieved despite embryo transfer in treatment has been identified as chromosome disorders that occur in embryos. In order to achieve a healthy and successful result in IVF treatments, it is necessary to analyze the embryos in detail and detect chromosomal abnormalities. Previously, the multidimensional and complex structure of chromosomes would have made multiple tests necessary. While this situation is quite time consuming and costly, the NGS (Next Generation Sequencing) test appears as a result of the developing technology today. The NGS method is a newly developed genetic analysis technology that allows comprehensive chromosome screening of embryos. The NGS method allows all embryos to be screened within a short period of time. With NGS, which offers a quick and detailed scan, chromosome-related problems are diagnosed before pregnancy. All 24 chromosomes are scanned with the NGS test.
Comprehensive chromosomal screening practices performed by the NGS method play an extremely important role in diagnosing disorders and have an effect on facilitating healthy outcomes in IVF treatments.
What are the Features of the NGS Technique?
Chromosomal abnormalities are determined by screening with the NGS method. Embryos containing more than two or more cell communities with different chromosomal structures are called “mosaic embryos”. Mosaic embryos are detected more easily with the NGS technique. After these chromosomal abnormalities detected by the NGS test are detected accurately and in detail, the process is advanced by including them in the treatment planning. Compared to the different PGD methods used to date and known, the NGS method provides a high-intensity scanning area, allowing you to detect even some genetic disorders, as well as numerical changes occurring in chromosomes.
What Genetic Defects Can Be Detected with NGS-Based PGS?
Embryos obtained in IVF treatment are evaluated according to various criteria in terms of the characteristics they have, and a healthy result is sought by ensuring the transfer of the embryo with the best developmental characteristics to the uterus. Examination of the developmental characteristics of the embryo under a microscope by classical methods does not give a clear information about the chromosomal state of the embryo. This information is only reached by performing a genetic screening with PGS. Even if the embryos have a good quality structure, they can contain various chromosomal problems, and this can also lead to problems such as early miscarriages, some structural disorders in the developing fetus, or the embryo does not hold on to the uterus. The main purpose of using the PGS method, which is an NGS-based method, is to increase the adhesion of the embryo to the uterus, which is found to have a chromosomally normal structure, to reduce the likelihood of miscarriage that may occur later, and as a result, to increase the likelihood of couples having healthy babies. The NGS-based PGS operation is performed by embryologists who have the necessary education and experience in this regard. The process takes a short time and does not cause any harm to the embryo. The PGS process begins by combining the egg taken from the expectant mother and the sperm taken from the expectant father outside the body. 5. Development of embryos from formed embryos. or 6. on the day when the blastocyst is at the stage, several cells are taken by biopsy without damaging the embryo. These received cells are sent to the genetic laboratory for a scan of 24 chromosomes, while the embryos are frozen. At this point, it is extremely important that the procedure is performed by a qualified embryologist so that the embryo does not get damaged. At the end of this examination, the embryo or embryos whose genetic structure has been determined to be healthy are transferred after completion of intrauterine preparation and pregnancy results that reach higher rates are obtained, especially.
To summarize briefly; NGS-based PGS is a genetic screening method and can be used to detect numerical and structural imbalances in chromosomes. However, single gene diseases, especially those with familial transmission, cannot be detected with the PGS method.
Who are the Groups of Patients Who Can Be Administered NGS?
The benefits of the NGS method, which is a new generation genetic analysis technology, also raises the question of which patient groups this technique can be applied to. Before answering this question, we can state that the intended point of the NGS method is to be able to detect numerical and structural changes in chromosomes. Therefore, we can address the question of which people have these changes more often for groups of patients who can be administered NGS. Groups of patients for whom NGS can be applied can be listed as follows;
· In cases of repeated miscarriage,
· in expectant mothers over the age of 38,
· In severe male infertility,
* In cases of infertility, the cause of which is unknown,
· It is applied in cycles of continuous self-recurring treatment failures.
The NGS method, which is a rapidly developing field, is actively used in many countries today due to its possibilities and facilitating and accelerating effects for the process.
What are the Advantages of Preimplantastone Genetic Screening with NGS?
NGS, a new genetic examination method used to screen for 24 chromosomes in embryos, provides the opportunity to examine and sequence the entire human genome both numerically and structurally in a short period of time, such as a single day. It offers us a revolutionary technology in this aspect. The improved NGS method can detect mosaic embryos better than other PGD methods. The main advantages of Preimplantastone Genetic Screening with NGS are that it allows you to quickly scan a large area of genes, both numerically and structurally. In addition to scanning gene fields numerically and structurally, the NGS method also has advantages such as obtaining a more accurate result with a low margin of error, achieving faster results, and having a lower cost. With this method, 24 chromosome screening can also be performed simultaneously with the study of single gene diseases and HLA typing.
Does NGS Damage the Embryo?
IVF treatments are an extremely exciting period for couples. During this period, in order to obtain a healthy result, various tests are applied to the embryos obtained to determine the success rate. In some cases, couples may have a high risk of genetically abnormal embryo development. Advanced maternal age is one of these conditions. Embryos that are not genetically normal are not suitable for transfer. In order to be able to determine the chromosomal status of embryos and to obtain a healthy result, process planning is carried out in the light of the NGS result. Another confusing situation for couples at this point is whether NGS causes any damage to the embryo during the application phase. Doctors who specialize in their field and NGS performed under appropriate conditions do not pose a danger risk to the embryo. At this point, managing and planning the process in accordance with the needs with a reliable specialist and institution will also be an extremely important step.
Does Pregnancy Always Occur With a Smoothly Detected Embryo?
After the tests and examinations, embryos that do not carry any genetic abnormalities are placed in the uterus. The probability of the occurrence of pregnancy after this procedure develops due to various factors. These factors;
· Women's age
· The amount of ovarian reserve of the woman
* Sperm quality
· Embryo quality
· Ensuring a proper intrauterine environment
· The presence of hydrosalpinx
· Conditions encountered during embryo transfer
it can be sorted as follows. All these factors are among the dec that affect the occurrence of pregnancy. From this point of view, it is impossible to say that pregnancy always occurs with an embryo that is detected without problems.
Studies have shown that age-related embryos are less likely to be chromosomally normal. For this reason, pregnancy rates are also decreasing due to the increasing age of women, especially in IVF trials that have not been applied to PGS. In women under the age of forty, NGS-based PGS normal embryos vary between 40 and 60 percent probability with the results of the analysis, the rate falls below twenty percent in people over the age of 40.
In women over the age of forty, a low pregnancy rate is achieved by transferring an embryo that has not been genetically screened with NGS, while this rate is increased by transferring an embryo that has been diagnosed with NGS and is chromosomally normal.
How Many Days Do NGS Results Come Out?
The embryos that have been biopsied are 5 or 6 until they reach the blastocyst stage. by following it up to the day, only embryos that have not been detected as abnormalities are transferred to the expectant mother's uterus (uterus). The NGS process applied to the embryos is completed within the same day. In this way, treatment planning is quickly directed.
What are the NGS Test Prices?
The information obtained from the results of the NGS test gives a comprehensive information for the IVF process. At this point, NGS, a new generation genetic screening test, has entered our lives as a result of high technology. It is a method that also has many advantages, especially if it provides a quick and wide information about the chromosomal state of the embryo. In addition to the advantages it provides, NGS is a method that also has an extremely low cost. This is a situation that also increases the availability of the test. As the Huma IVF family, we continue to be there for our couples during this exciting process. For all your questions about NGS, you can review our site and contact us for detailed information.
In this article, we have included details about the NGS method. It is important to detect embryos that do not have chromosomal abnormalities, as well as to successfully transfer the embryos obtained in IVF treatments to the uterus. Comprehensive chromosomal screening practices performed by the NGS method play an extremely effective role in detecting chromosomal disorders in embryos and increase the risk of a positive outcome of the process.
Foods That Boost Fertility: A Nutritional Guide for IVF Patients
Foods That Boost Fertility: A Nutritional Guide for IVF Patients
Embarking on an IVF journey can be both exciting and overwhelming. While medical advancements have significantly increased the chances of conception, diet plays a crucial role in supporting reproductive health and improving IVF success rates. A well-balanced diet rich in essential nutrients can enhance fertility, regulate hormones, and improve overall well-being. In this guide, we will explore the best fertility-boosting foods for IVF patients.
1. The Role of Nutrition in IVF Success
Nutrition has a direct impact on reproductive health. A diet rich in antioxidants, healthy fats, vitamins, and minerals can improve egg quality, support embryo development, and enhance uterine health. Conversely, unhealthy eating habits, excessive processed foods, and trans fats may negatively affect fertility.
2. Fertility-Boosting Foods for IVF Patients
A. Antioxidant-Rich Foods
Antioxidants help reduce oxidative stress, which can damage egg and sperm cells. Incorporate these antioxidant-rich foods into your diet:
Berries (strawberries, blueberries, raspberries) – High in vitamin C and folate.
Dark leafy greens (spinach, kale, Swiss chard) – Loaded with folic acid and iron.
Nuts and seeds (walnuts, almonds, flaxseeds, chia seeds) – Contain vitamin E and selenium, crucial for reproductive health.
Dark chocolate (with at least 70% cocoa) – Rich in flavonoids that support blood circulation to reproductive organs.
B. Healthy Fats
Healthy fats are essential for hormone production and egg quality. Opt for:
Avocados – A great source of monounsaturated fats that promote hormone balance.
Olive oil – Anti-inflammatory properties support embryo implantation.
Fatty fish (salmon, sardines, mackerel) – Rich in omega-3 fatty acids, crucial for reproductive health.
Nuts and seeds – Provide healthy fats and essential micronutrients.
C. Protein Sources
Protein is vital for cell development and hormone production. Prioritize:
Lean meats (chicken, turkey, lean beef) – Provide high-quality protein and iron.
Eggs – Contain choline and vitamin D, essential for fertility.
Legumes (lentils, chickpeas, beans) – Plant-based proteins that boost hormonal balance.
Greek yogurt – A probiotic-rich dairy option that supports gut health and nutrient absorption.
D. Whole Grains
Whole grains provide sustained energy and improve insulin sensitivity, which is crucial for reproductive health. Include:
Quinoa – A gluten-free, protein-rich grain with essential amino acids.
Brown rice – Supports blood sugar balance and ovulation.
Oats – High in fiber, promoting digestive health and hormonal balance.
Whole wheat bread – Provides essential B vitamins for reproductive function.
E. Hydration and IVF Success
Proper hydration is key to reproductive health. Drinking enough water helps maintain cervical mucus, improves egg health, and enhances nutrient absorption. Aim for at least 8-10 glasses of water daily, and include herbal teas like ginger or peppermint for additional benefits.
3. Foods to Avoid During IVF Treatment
Certain foods can negatively impact fertility and IVF success. Limit or avoid:
Processed foods – High in trans fats and artificial additives that disrupt hormonal balance.
Excess caffeine – May reduce fertility and interfere with implantation.
Sugary foods and beverages – Can cause insulin spikes, affecting ovulation.
Alcohol – Lowers fertility rates and negatively impacts egg and sperm quality.
Soy-based products – Excessive soy can disrupt estrogen levels.
4. Final Tips for a Fertility-Boosting Diet
Follow the Mediterranean diet – This diet, rich in whole foods, healthy fats, and lean proteins, is linked to improved IVF success rates.
Maintain a balanced meal plan – Aim for variety and include a mix of macronutrients.
Consult a nutritionist – If needed, seek guidance for a personalized diet plan.
Stay active and manage stress – Regular physical activity and stress reduction techniques, such as yoga or meditation, can further support fertility.
Conclusion
A fertility-focused diet can significantly enhance IVF success rates by improving egg quality, regulating hormones, and creating an optimal environment for conception. By incorporating nutrient-dense foods and avoiding fertility-disrupting substances, you can support your journey toward parenthood. Always consult with your fertility specialist or nutritionist to tailor a diet plan suited to your specific needs.
Are you ready to take charge of your IVF journey through nutrition? Start today by making small, healthy changes that will benefit your reproductive health and overall well-being!
How to Improve Egg Productivity & Quality
How to Improve Egg Productivity & Quality
Fertility is a crucial aspect of reproductive health, and for women, egg productivity and quality play a vital role in conception. The number and quality of eggs naturally decline with age, but various lifestyle changes, diet improvements, and medical interventions can help maintain and enhance ovarian health. Whether you are planning for pregnancy now or preserving fertility for the future, here are some effective ways to boost egg productivity and quality.
1. Maintain a Balanced and Nutrient-Rich Diet
What you eat directly impacts your reproductive health. A fertility-friendly diet should include:
Antioxidants: Found in berries, nuts, and leafy greens, antioxidants help protect eggs from oxidative stress.
Healthy Fats: Avocados, olive oil, and nuts support hormonal balance and egg cell membrane integrity.
Protein Sources: Include lean meats, fish, eggs, and plant-based proteins like beans and lentils to promote healthy egg development.
Folic Acid & B Vitamins: Essential for cell division and DNA synthesis. Found in leafy greens, citrus fruits, and fortified grains.
Omega-3 Fatty Acids: Found in salmon, flaxseeds, and walnuts, they enhance egg quality and overall reproductive health.
2. Stay Hydrated
Drinking enough water is essential for circulation and nutrient transport to the ovaries. Dehydration can negatively affect egg development and hormone production.
3. Maintain a Healthy Weight
Being overweight or underweight can disrupt hormonal balance and ovulation. Maintaining a BMI within a healthy range supports regular ovulation and egg maturation.
4. Reduce Stress Levels
Chronic stress increases cortisol levels, which can interfere with reproductive hormones and egg development. Stress management techniques include:
Meditation & Yoga: Help regulate stress hormones and improve blood flow to reproductive organs.
Regular Exercise: Moderate physical activity boosts circulation and hormone regulation.
Adequate Sleep: 7-9 hours of quality sleep each night supports hormone balance and overall health.
5. Avoid Toxins and Harmful Substances
Reduce Caffeine & Alcohol: Excessive intake can negatively affect fertility.
Quit Smoking: Smoking accelerates ovarian aging and reduces egg quality.
Limit Exposure to Environmental Toxins: Pesticides, plastics (BPA), and heavy metals can harm egg health. Opt for organic foods and use BPA-free products.
6. Take Fertility-Boosting Supplements
Certain vitamins and supplements can enhance egg quality:
Coenzyme Q10 (CoQ10): Improves egg cell energy and mitochondrial function.
Vitamin D: Supports ovarian function and hormonal balance.
Zinc & Selenium: Help protect eggs from oxidative stress and improve overall reproductive health.
DHEA (Dehydroepiandrosterone): A precursor hormone that can help improve ovarian reserve in some cases (consult a doctor before use).
7. Consider Medical Interventions if Necessary
If you are struggling with fertility issues, consult a specialist who may recommend:
Hormonal Therapy: Helps regulate ovulation and improve egg development.
Ovulation Induction Medications: Clomiphene citrate or Letrozole can stimulate egg production.
IVF (In Vitro Fertilization): If natural conception is difficult, IVF can retrieve multiple eggs for fertilization.
PRP (Platelet-Rich Plasma) Therapy: An emerging treatment that may help rejuvenate ovarian function.
8. Monitor Your Ovarian Reserve
Regular fertility check-ups can help assess egg quality and quantity. Tests such as:
AMH (Anti-Müllerian Hormone) Test: Measures ovarian reserve.
FSH & Estradiol Tests: Assess ovarian function and hormone levels.
Antral Follicle Count (AFC) via Ultrasound: Provides insights into egg supply.
Conclusion
Improving egg productivity and quality requires a holistic approach that includes a healthy diet, lifestyle adjustments, and, if needed, medical assistance. By adopting these strategies, you can enhance your fertility potential and increase your chances of a successful pregnancy. If you are planning for the future, consider consulting a fertility specialist for personalized guidance on preserving and optimizing your reproductive health.
