Why Hüma
About Hüma International Hospital
Founded in March 2004 as Kayseri’s first dedicated Women’s Health Center, Hüma has continually expanded its scope of medical services to meet the evolving needs of its patients. In 2006, the institution grew into a full-fledged Gynecology and Obstetrics Hospital, broadening its reach and enhancing its capacity to provide specialized care for women. The hospital further solidified its position as a leader in women’s healthcare by establishing a state-of-the-art IVF Center in 2014, offering cutting-edge fertility treatments backed by the latest advancements in reproductive medicine.
Today, Hüma International Hospital has become a trusted name in gynecology, obstetrics, fertility, and urogynecology, providing evidence-based, modern, and patient-centered healthcare. With a team of highly experienced physicians, nurses, and medical specialists, Hüma is committed to delivering superior healthcare services through advanced medical technology and a compassionate approach.
International Patient Services
Understanding the unique needs of international patients, Hüma International Hospital has established a comprehensive International Patient Services Center, designed as a “one-stop” service hub. This center is dedicated to ensuring a seamless and comfortable healthcare experience for patients traveling from abroad. From the initial inquiry to post-treatment follow-up and the patient’s safe return home, the International Patient Services Team provides personalized support at every step of the journey.
Why Choose Hüma International Hospital?
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Highly Experienced Medical Team: Renowned physicians, nurses, and fertility specialists with extensive expertise.
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Exceptional Success Rates: Proven track record in IVF, gynecology, and obstetrics.
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Personalized Treatment Plans: Tailored medical approaches designed to meet each patient’s specific needs.
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Uncompromising Patient Satisfaction: A commitment to excellence in healthcare and patient care.
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Affordable & Transparent Pricing: Cost-effective treatments with no hidden fees, offering Europe’s most competitive pricing in fertility and gynecological care.
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Best Price Guarantee: High-quality treatments at the most affordable rates.
At Hüma International Hospital, we prioritize medical excellence, patient well-being, and ethical healthcare practices, ensuring that every patient receives the highest standard of treatment in a safe and comfortable environment
TESE - TESA Practices
Micro TESE is a painless procedure performed under anesthesia. The aim here is to enlarge the tissue under the microscope and remove the tissues with a high probability of containing sperm. Therefore, while the probability of finding sperm increases in theory, the damage to the testis decreases as less tissue is taken. Tissue samples taken are subjected to a series of processes and living sperm cells are separated. While these cells are used in the microinjection process, sperm are stored in other observed tissues for use in different experiments. Points to consider before micro-TESE You should not eat or drink anything (including water) for at least 6 hours before the operation. · Clean the operation area with a razor blade. Take a bath.
Bring loose
trousers or sweatpants with you as pressure on the testicles will cause pain after the operation. You will be discharged 1-2 hours after the operation. Points to consider after micro TESE Liquid food intake can be started within 3 hours after the
operation. You can take a bath on the 5th day after the operation. · Do not have sexual intercourse for 1 week. If you have pain, you can use painkillers. If you experience redness, swelling or bleeding at the operation site, inform your doctor.
Since
self-dissolving sutures are used during Micro TESE, there is no suture removal process. The stitches will dissolve by themselves in 7-10 days. Risks As a result of micro TESE, viable sperm cells may not be obtained. This risk depends on the underlying cause. The chance of finding sperm in a patient with obstruction in the sperm ducts; higher than the patient with hormonal or genetic problems. Postoperatively, infection and bleeding may occur at the operation site.
Microchip
In patients with low sperm viability, quantity, number and structural quality, microfluidic technology, also known as the "chip baby method", ensures that the best quality sperm cells are selected by competing with each other in a way similar to the natural environment in the uterus, and ICSI is defined in in vitro fertilization treatment. With the application, it is left into the egg cell by microinjection method.
In this method, sperm cells with the best structural form, genetics and physiology are selected without causing cell damage, since techniques such as centrifugation (settling), vortex (mixing with high vibration) or mixing with a pipette are not applied to the sperm cells, which can physically damage the sperm cells. In classical preparation methods, sperm cells are prepared in a shorter time without being subjected to manipulation by skipping processes such as washing, flotation, gradient (grading), centrifugation (precipitation at high speeds). Thus, the sperm cells with the best DNA quality and physiologically are selected by themselves, and the sperm cells that pass this pre-screening are again screened under the microscope and the sperm cells of excellent quality are used for microinjection.
The above-mentioned classical preparation methods cause sperm cells to undergo respiratory stress, known as oxidative stress, and it has been scientifically proven that this can also cause DNA damage in healthy sperm cells. Better quality embryos are tried to be obtained with sperm cells that have been proven to be of the best quality by scientific data, and thus embryos with the highest potential for implantation (attachment) and development are obtained. The average total mobility in suckling samples taken from male individuals with microchip technology increased by 1.7 times.
The sperm cells obtained by this method were found 3 times faster than the classical preparation methods, and the forward motile sperm cells increased 3.8 times.
WHAT IS THE SPERMIOGRAM TEST FOR ANALYSIS OF SPERM CELL?
Parents who want to have children generally prefer the most common in vitro fertilization treatment. Before this treatment, both mother-to-be and father-to-be go through many tests. Father-to-be passed; The first of the tests to test for infertility or other problems is the sperm test, also known as the spermiogram test. What is the spermiogram test for the analysis of the sperm cell? How is spermiogram done? What do spermiogram test results mean? We will answer all these questions for you in detail below. We recommend that you continue reading our article to have detailed information about the sperm test.
What is a test (spermiogram)?
Sperm test done to men; It is a test to determine sperm health, sperm count, and whether the sperm are moving correctly in the channels. As a result of the sperm test, if the sperm shape is normal and there is a sufficient number of sperm, it is concluded that your reproductive ability is high. However, in some cases, men may have low sperm count or the ability to reproduce despite having abnormal semen. That's why doctors order a second test for the accuracy of the results. If your results are normal in your first sperm test, you give the other test and if it is normal, these two normal tests show that you do not have an infertility problem. If there are different conditions, your doctor may order other tests.
If there is no semen or sperm as a result of the sperm test, this may indicate that your ducts are blocked. If this is the case, your doctor will plan different surgeries to open the channels.
Issues and Precautions to Consider While Giving Sperm Sample
There are important points to be considered before giving the sperm sample and while giving the sperm sample. Among the things to be considered before giving a sperm sample, we can count that "men should abstain from sexual intercourse for 3 days". Fasting for 3 to 5 days is sufficient. These numbers are important because if you fast for less than 3 days, the sperm count may be low as a result of the sperm test. For this reason, we can say that fasting between 3 and 5 days is sufficient. It is possible to list the issues to be considered while giving a sperm sample as follows;
· Storing the sample in a sterile environment: It is important to protect your sample from the outside environment for a healthy and accurate spermiogram test result. If a sterile environment is not provided, the test result may be inaccurate. Therefore, do not put your hands, especially sample containers, etc. It is important that you keep it as sterile as possible.
· Protecting the delivered sperm from heat: Another important point is to keep your sample away from extreme temperature changes after ejaculation. Because these extreme temperature changes negatively affect spermatozoa. Ideal temperatures for the sample cup should be between 20°C and 37°C.
· Sperm volume, amount: Volume is extremely important in the sperm test. Your sperm volume is expected to be at least 1.5 ml. The reason why you cannot reach the lower limit of 1.5 ml may be external discharge during ejaculation. It is important to be careful about this.
· Use of lubricating foreign substances during the sperm test: It is important not to use any lubricant during the sperm test because these substances seriously affect the sperm parameters. External factors with such an impact can lead to wrong conclusions.
How is the Sperm Test Done?
For the sperm test, you must first be at the IVF center or hospital. There are rooms specially prepared for men in hospitals or IVF centers. In these rooms, men give their sperm in a special container. For the effectiveness of the sperm test, the sperm sample is immediately delivered to the laboratory. The sperm sample given in the laboratory is subjected to many processes and the best quality sperms are selected. The purpose of the procedures is to examine the sperm count, motility and shape in the semen and to reach quality sperm as a result.
Apart from the hospital, sperm samples can be placed in a container and brought to the hospital in the home environment. However, this is highly not recommended. Even if this is accepted, the sperm samples should be brought to the hospital and delivered within half an hour.
Issues and Precautions to Consider When Analyzing Sperm Sample
For the sperm test, you must first be at the IVF center or hospital. There are rooms specially prepared for men in hospitals or IVF centers. In these rooms, men give their sperm in a special container. For the effectiveness of the sperm test, the sperm sample is immediately delivered to the laboratory. The sperm sample given in the laboratory is subjected to many processes and the best quality sperms are selected. The purpose of the procedures is to examine the sperm count, motility and shape in the semen and to reach quality sperm as a result.
Apart from the hospital, sperm samples can be placed in a container and brought to the hospital in the home environment. However, this is highly not recommended. Even if this is accepted, the sperm samples should be brought to the hospital and delivered within half an hour.
Issues and Precautions to Consider When Analyzing Sperm Sample
After the sperm test is given by the prospective fathers, it is examined in the laboratory environment. This examination takes approximately 1-2 hours and after the first hour, active results begin to be obtained. However, sometimes different situations can be encountered. For example, the test is given, but no sperm can be seen when looked at. In these cases, sperm are taken again and centrifuged. When faced with such a situation, the time may be extended. If there is no additional test to be done, the test results are immediately available in an average of 1-1.5 hours.
What Do Sperm Test Results Mean?
Sperm test results can be evaluated in many ways. Sperm analysis evaluates the sperm by analyzing it from various aspects. We can list these analyzes as follows:
· Sperm count and density:
Sperm count describes the number of sperm in 1 ml of semen. The World Health Organization advocates that a normal sperm count should be at least 15 million per ml or at least 39 million per sample. Having fewer sperm than these numbers indicates a low sperm count.
· Sperm morphology:
Non-abnormal sperm have a long tail and oval head. Morphology refers to the size and shape of the sperm a person has. Sperm that do not have a normal size or are weak in shape have difficulty reaching the egg and fertilization.
· Sperm motility:
The ability of sperm to move efficiently is one of the most important factors for fertilization.
· PH level of sperm:
When the pH level is too high or too low, it can affect the health of sperm and its ability to pass through the female reproductive tract.
Apart from these, sperm health is examined by looking at many factors such as semen volume, liquefaction, and seminal fructose levels while performing the sperm test. After examining all factors in detail, the results are examined and reported to the patient.
What is the Sperm Test Result of a Healthy Individual?
Low sperm count can have many different causes. The first reason is smoking addiction. Smoking addiction is one of the important factors that reduce the sperm count. In addition to smoking, alcohol and drug addiction also affect sperm count. Sperm count can also be adversely affected when there is a deficiency in hormones, depending on the clogged ducts.
Hormones are one of the important factors for reproduction on their own. Since the deficiency in reproductive hormones directly affects sperm production, it increases the possibility of encountering problems in reproduction. Apart from these, mistakes made by couples who want to have children also affect the sperm count. Using natural products unconsciously and continuing to use them uncontrollably, without knowing the limit, does harm to the person instead of providing benefits. Long-term treatment and drugs used during the treatment also affect the sperm count.
IMSI in Sperm Selection
The IMSI (Intracytoplasmic Morpholgically Selected Sperm Injection) method is the magnification and examination of even the smallest cells using special microscopes. In the past, in the microinjection procedures applied in IVF treatments, living sperm cells could be enlarged up to 400 times. However, with IMSI, sperm can now be enlarged between 6000 and 8000 times. It is possible to examine and detect in detail the disorders called "vacuoles" that indicate the intracellular structures of the sperm and their genetic damage.
The IMSI technique is an extremely useful method. Selected sperm injection; It allows advanced morphological analysis of sperm without damaging the living sperm cell. Sperm with the highest fertilization ability are selected and a high chance of fertilization between 20% and 40% can be obtained with the applied microinjection application.
Precautions to be Considered for Sperm Quality
Couples who want to have children should pay attention to egg and sperm health and be careful in this regard. There are many factors that affect sperm quality, such as those that affect egg quality. One of these factors is undoubtedly a healthy diet. A healthy diet is extremely important for every organ in the body, of course also in sperm health.
In addition, exercise is very important in making you more vigorous and increasing your body's stamina and activity. Regular exercise will make you recover in a short time and will positively affect both your mental and physical health. Alcohol and smoking are substances that affect reproductive cells and should be avoided. This is a proven fact as a result of research. If we gather all these under one title, we can say that one should take care of his own health. Nutrition, avoiding alcohol, smoking, exercising regularly will first affect your health and therefore your sperm quality.
This process, which is sensitive and special for couples who want to have a child, is extremely important for them. In this process, prospective parents experience excitement on the one hand and a lot of stress on the other. Hüma IVF Center, which understands the emotions experienced best and does not spare its support by being by their side throughout the process, is always ready to accompany you.
WHAT IS COMPREHENSIVE CHROMOSOME SCREENING (NGS)?
IVF treatments are supported by a wide range of tests and analyzes to get a healthy result. With the help of these tests, problems that may occur before and after pregnancy are also detected and planning is carried out in this direction. NGS, a genetic analysis technology that allows comprehensive chromosome screening to be performed in embryos, is a test that gives extremely effective results as technological developments gain momentum. With NGS, embryos are scanned quickly and effectively, and genetic problems at the chromosome level are detected before pregnancy. The aim of this method is to select a healthy embryo by performing genetic analysis on embryos before the transfer process and to increase the chances of a healthy pregnancy. You can continue reading our article for the details of the NGS test.
What is Comprehensive Chromosome Screening (NGS)?
It is extremely important that the embryos obtained in IVF treatments are successfully transferred to the uterus. But in some cases, pregnancy may not be achieved. One of the most important reasons why a healthy pregnancy cannot be achieved despite embryo transfer in treatment has been identified as chromosome disorders that occur in embryos. In order to achieve a healthy and successful result in IVF treatments, it is necessary to analyze the embryos in detail and detect chromosomal abnormalities. Previously, the multidimensional and complex structure of chromosomes would have made multiple tests necessary. While this situation is quite time consuming and costly, the NGS (Next Generation Sequencing) test appears as a result of the developing technology today. The NGS method is a newly developed genetic analysis technology that allows comprehensive chromosome screening of embryos. The NGS method allows all embryos to be screened within a short period of time. With NGS, which offers a quick and detailed scan, chromosome-related problems are diagnosed before pregnancy. All 24 chromosomes are scanned with the NGS test.
Comprehensive chromosomal screening practices performed by the NGS method play an extremely important role in diagnosing disorders and have an effect on facilitating healthy outcomes in IVF treatments.
What are the Features of the NGS Technique?
Chromosomal abnormalities are determined by screening with the NGS method. Embryos containing more than two or more cell communities with different chromosomal structures are called “mosaic embryos”. Mosaic embryos are detected more easily with the NGS technique. After these chromosomal abnormalities detected by the NGS test are detected accurately and in detail, the process is advanced by including them in the treatment planning. Compared to the different PGD methods used to date and known, the NGS method provides a high-intensity scanning area, allowing you to detect even some genetic disorders, as well as numerical changes occurring in chromosomes.
What Genetic Defects Can Be Detected with NGS-Based PGS?
Embryos obtained in IVF treatment are evaluated according to various criteria in terms of the characteristics they have, and a healthy result is sought by ensuring the transfer of the embryo with the best developmental characteristics to the uterus. Examination of the developmental characteristics of the embryo under a microscope by classical methods does not give a clear information about the chromosomal state of the embryo. This information is only reached by performing a genetic screening with PGS. Even if the embryos have a good quality structure, they can contain various chromosomal problems, and this can also lead to problems such as early miscarriages, some structural disorders in the developing fetus, or the embryo does not hold on to the uterus. The main purpose of using the PGS method, which is an NGS-based method, is to increase the adhesion of the embryo to the uterus, which is found to have a chromosomally normal structure, to reduce the likelihood of miscarriage that may occur later, and as a result, to increase the likelihood of couples having healthy babies. The NGS-based PGS operation is performed by embryologists who have the necessary education and experience in this regard. The process takes a short time and does not cause any harm to the embryo. The PGS process begins by combining the egg taken from the expectant mother and the sperm taken from the expectant father outside the body. 5. Development of embryos from formed embryos. or 6. on the day when the blastocyst is at the stage, several cells are taken by biopsy without damaging the embryo. These received cells are sent to the genetic laboratory for a scan of 24 chromosomes, while the embryos are frozen. At this point, it is extremely important that the procedure is performed by a qualified embryologist so that the embryo does not get damaged. At the end of this examination, the embryo or embryos whose genetic structure has been determined to be healthy are transferred after completion of intrauterine preparation and pregnancy results that reach higher rates are obtained, especially.
To summarize briefly; NGS-based PGS is a genetic screening method and can be used to detect numerical and structural imbalances in chromosomes. However, single gene diseases, especially those with familial transmission, cannot be detected with the PGS method.
Who are the Groups of Patients Who Can Be Administered NGS?
The benefits of the NGS method, which is a new generation genetic analysis technology, also raises the question of which patient groups this technique can be applied to. Before answering this question, we can state that the intended point of the NGS method is to be able to detect numerical and structural changes in chromosomes. Therefore, we can address the question of which people have these changes more often for groups of patients who can be administered NGS. Groups of patients for whom NGS can be applied can be listed as follows;
· In cases of repeated miscarriage,
· in expectant mothers over the age of 38,
· In severe male infertility,
* In cases of infertility, the cause of which is unknown,
· It is applied in cycles of continuous self-recurring treatment failures.
The NGS method, which is a rapidly developing field, is actively used in many countries today due to its possibilities and facilitating and accelerating effects for the process.
What are the Advantages of Preimplantastone Genetic Screening with NGS?
NGS, a new genetic examination method used to screen for 24 chromosomes in embryos, provides the opportunity to examine and sequence the entire human genome both numerically and structurally in a short period of time, such as a single day. It offers us a revolutionary technology in this aspect. The improved NGS method can detect mosaic embryos better than other PGD methods. The main advantages of Preimplantastone Genetic Screening with NGS are that it allows you to quickly scan a large area of genes, both numerically and structurally. In addition to scanning gene fields numerically and structurally, the NGS method also has advantages such as obtaining a more accurate result with a low margin of error, achieving faster results, and having a lower cost. With this method, 24 chromosome screening can also be performed simultaneously with the study of single gene diseases and HLA typing.
Does NGS Damage the Embryo?
IVF treatments are an extremely exciting period for couples. During this period, in order to obtain a healthy result, various tests are applied to the embryos obtained to determine the success rate. In some cases, couples may have a high risk of genetically abnormal embryo development. Advanced maternal age is one of these conditions. Embryos that are not genetically normal are not suitable for transfer. In order to be able to determine the chromosomal status of embryos and to obtain a healthy result, process planning is carried out in the light of the NGS result. Another confusing situation for couples at this point is whether NGS causes any damage to the embryo during the application phase. Doctors who specialize in their field and NGS performed under appropriate conditions do not pose a danger risk to the embryo. At this point, managing and planning the process in accordance with the needs with a reliable specialist and institution will also be an extremely important step.
Does Pregnancy Always Occur With a Smoothly Detected Embryo?
After the tests and examinations, embryos that do not carry any genetic abnormalities are placed in the uterus. The probability of the occurrence of pregnancy after this procedure develops due to various factors. These factors;
· Women's age
· The amount of ovarian reserve of the woman
* Sperm quality
· Embryo quality
· Ensuring a proper intrauterine environment
· The presence of hydrosalpinx
· Conditions encountered during embryo transfer
it can be sorted as follows. All these factors are among the dec that affect the occurrence of pregnancy. From this point of view, it is impossible to say that pregnancy always occurs with an embryo that is detected without problems.
Studies have shown that age-related embryos are less likely to be chromosomally normal. For this reason, pregnancy rates are also decreasing due to the increasing age of women, especially in IVF trials that have not been applied to PGS. In women under the age of forty, NGS-based PGS normal embryos vary between 40 and 60 percent probability with the results of the analysis, the rate falls below twenty percent in people over the age of 40.
In women over the age of forty, a low pregnancy rate is achieved by transferring an embryo that has not been genetically screened with NGS, while this rate is increased by transferring an embryo that has been diagnosed with NGS and is chromosomally normal.
How Many Days Do NGS Results Come Out?
The embryos that have been biopsied are 5 or 6 until they reach the blastocyst stage. by following it up to the day, only embryos that have not been detected as abnormalities are transferred to the expectant mother's uterus (uterus). The NGS process applied to the embryos is completed within the same day. In this way, treatment planning is quickly directed.
What are the NGS Test Prices?
The information obtained from the results of the NGS test gives a comprehensive information for the IVF process. At this point, NGS, a new generation genetic screening test, has entered our lives as a result of high technology. It is a method that also has many advantages, especially if it provides a quick and wide information about the chromosomal state of the embryo. In addition to the advantages it provides, NGS is a method that also has an extremely low cost. This is a situation that also increases the availability of the test. As the Huma IVF family, we continue to be there for our couples during this exciting process. For all your questions about NGS, you can review our site and contact us for detailed information.
In this article, we have included details about the NGS method. It is important to detect embryos that do not have chromosomal abnormalities, as well as to successfully transfer the embryos obtained in IVF treatments to the uterus. Comprehensive chromosomal screening practices performed by the NGS method play an extremely effective role in detecting chromosomal disorders in embryos and increase the risk of a positive outcome of the process.
