IVF Treatment And Fertility
Every woman wants to feel the maternity. We try to see smiling on your face for that very small breath to be included into your world. We, as Huma IVF Center, plan to be with you in this process from the first step of your treatment to your birth with awareness of your infertility problems. We target to bring you together with the healthy individuals in your home while starting with the slogan ‘Let us Add Your Imagination into Your Life’, believe that you will feel safe and in peace in our center. We take the fair pride in presenting the high quality service to you with a principle trying to catch the world standards with our knowledge.
WHY IS HUMA IVF CENTER?
Our success in the assisted reproductive treatments is based on a team working in plan and in coordination.
Our team consisted of the gynaecologists, embryologists, nurses and the patient consultants expert at their subjects, open to share information shall be glad to give service to you in this way where you started in order to be able to have a child.
Huma IVF Center started out by making renewing itself every passing day in the infertility practices a rule. We are over the world standards at rates of pregnancy to be obtained by using the assisted reproductive techniques.
Our patient consultants are in your service in all stages of your treatments in order to ease the IVF center treatment processes of our patients who will come to our center for treatment from abroad. We enable accommodation at a discount in our contractual hotels and the transportation support, prepare the programs where you will be able to follow your treatment at a distance.
IVF Center Treatment Techniques
• TESE- TESA Practices
• PGT (Pre-implantation Genetic Diagnostic)
• Calcium Ionophore
• Intra lipid
• Asisted Hatching
• Microchip
• Embryoscopy
• Pool Method
• Uterus Resting
• PRP
Medical Aesthetic
Natural and artificial factors, especially aging, can cause the skin to lose its old appearance and become deformed. Surgical and non-surgical methods continue to be frequently preferred by people who are dissatisfied with their external appearance.
Hüma Hospital offers you health and beauty together in its Medical Aesthetics Clinic, which prioritizes professionalism and high-level technology.
BOTOX PROCESSES
What is Botox?
Botox , botulinum It is an abbreviation of the word toxin . Bacteria is a condensed type of protein. By acting on a substance called acetylcholine , which provides this communication between the brain and muscle , Botox prevents the contraction of small muscle groups that cause the appearance of wrinkles on the face and ensures that wrinkles are minimized.
It provides a more aesthetic appearance to the person by showing the effect of eliminating the appearance of wrinkled and old skin in a short time. Botox also provides expression design.
Because of the lines on the face, people who have an angry and stressful stance can easily get rid of this situation with botox .
How is Botox applied?
Botox application is done through a thin needle tip. Specially designed small injectors are used with a thin needle. The application is made to the muscle layer. During the Botox procedure, a slight burning sensation, like a needle stick, is felt. Other than that, no pain is felt. However, local anesthetic cream and ice are applied to sensitive individuals during the procedure.
How Long Does Botox Effect Last?
of Botox lasts up to 4-6 months. In repetitive botox applications, this period is prolonged in many patients. The effect of Botox does not end abruptly 4-6 months after it is made, it disappears over time. A person who has had botox for a long time will have fewer wrinkles than if he has never had botox, even after the procedure has lost its effect. That's why botox is also used as an anti-wrinkle treatment.
Facial Botox
Eye area Botox
Forehead Botox
Between Eyebrows Botox
Upper lip (Smoking lines) Botox
Lip Edge (sad face) Botox
Gummy Smile (The appearance of the gums when smiling) Botox
Upper Nose (Rabbit lines) Botox
Masseter (Chewing) Botox
Nefertiti (Neck and Decollete) Botox
Hands and palms Botox
Sweating Botox
Migraine Botox
FILLING PROCESSES
Nose Filling: It is a painless and painless procedure that provides an aesthetic nose appearance without the need for surgery in people who have problems such as curvature and symmetry in the nose area, droopy nose tip .
anesthetic cream is applied to the area to be applied, waiting for 15-20 minutes and the area is disinfected, and the filling material is injected under the skin in appropriate doses.
After this procedure, which lasts for an average of 1-1.5 years and takes about 15-20 minutes, the person can return to his daily life immediately.
The biggest advantage of nasal filling is that the desired shape can be given to the nose of the person. A better profile view can be obtained by filling the gaps in the main bone. In the same way, nasal tip deformities can be eliminated to a certain extent and the nose can be given a more upturned appearance.
Cheek-Cheek Filling : With the cheek filling technique, which is made to find practical and quick solutions to aesthetic problems on the face, volume deficiencies in the cheeks of the person can be successfully treated with an operation that takes 15 minutes. Hyaluronic acid filling , which is found in the natural structure of the skin, is generally preferred as a filling material.
Lip Filling : Lip augmentation, which is applied to add volume to the lips and increase their aesthetic appearance, is a painless filling process that takes 10-15 minutes.
Nasolabial Filling: Nasolabial lines , which are known as laugh lines among the people, appear more clearly when people laugh. With the nasolabial filling process, the appearance of deep pits is eliminated and the tissues in this area have a more vivid and fuller appearance.
Under-Eye Light Filling: Under-eye bags, bruises and swellings, depending on the genetic structure of the person, usually begin to become more pronounced in the 30s . With under-eye light filling, people's under-eyes get a healthy appearance without pain and pain. The permanence of this process, which is made by allowing the gel with a high water content of hyaluronic acid to dissolve in the body, is 1-1.5 years.
Chin and Jawline Filling:It is a method applied to people whose forward or backward stance in the chin impairs facial aesthetics or who want a more pronounced chin appearance. It is done by anesthetizing the person's chin area and injecting the appropriate dose of hyaluronic acid filler . The chin filling session takes about 15 minutes and the healing process is fast.
Temple Filling: It is a botox procedure that is performed to ensure facial harmony and makes the temples more pronounced .
PINK GLOW:
One of the most popular applications of the last period, which ensures the renewal of the skin, Paris Shine is one of the aesthetic applications performed to make the face shadow look younger and healthier.
How to Apply Paris Shine?
Local After skin cleansing, anesthetic cream is applied to sensitive individuals and waited for 20 minutes. It is then injected with a mesotherapy needle by forming a papule (with a slight swelling of the skin).
It can be applied to points of aging such as face, neck, décolleté and hands to give a fresher and brighter appearance. With the Paris glow, which can be repeated with certain sessions, the differences in your skin will show itself as vitality, brightness and youth, and you will feel more beautiful.
Face Lift with Rope Strap (French Strap): It is one of the non-surgical face rejuvenation methods with flexible ropes compatible with the human body to raise the tissue under the skin surface. People who are dissatisfied with their facial features and have complaints of wrinkles and sagging can make their choices with expert opinion Rope Strap alternatives according to their skin conditions.
Rope Axis Application Areas
In this method, although the application areas of the rope hanger may vary according to mimic movements, they are mostly the same. We can list the rope suspension application areas on the face and body as follows:
• cheeks
• Gill
• cheekbones
• oval line of the face
• forehead lines
• crow's feet
• Kas region
• Neck
Process time
• The patient does not feel pain or pain during the rope suspension application under local anesthesia.
• Depending on the procedure to be performed, the time may vary. However, it is usually completed in 20 minutes.
• There is no need for stitches in the rope suspension application applied to the patient.
• During the procedure, it is ensured that the threads are attached to the ear inside the head.
• In case of stretching for the body, rope hangers are attached to different areas.
• No clinical rest or home rest is required after the procedure.
• Individuals can return to their daily life.
TESE - TESA Practices
Micro TESE is a painless procedure performed under anesthesia. The aim here is to enlarge the tissue under the microscope and remove the tissues with a high probability of containing sperm. Therefore, while the probability of finding sperm increases in theory, the damage to the testis decreases as less tissue is taken. Tissue samples taken are subjected to a series of processes and living sperm cells are separated. While these cells are used in the microinjection process, sperm are stored in other observed tissues for use in different experiments. Points to consider before micro-TESE You should not eat or drink anything (including water) for at least 6 hours before the operation. · Clean the operation area with a razor blade. Take a bath.
Bring loose
trousers or sweatpants with you as pressure on the testicles will cause pain after the operation. You will be discharged 1-2 hours after the operation. Points to consider after micro TESE Liquid food intake can be started within 3 hours after the
operation. You can take a bath on the 5th day after the operation. · Do not have sexual intercourse for 1 week. If you have pain, you can use painkillers. If you experience redness, swelling or bleeding at the operation site, inform your doctor.
Since
self-dissolving sutures are used during Micro TESE, there is no suture removal process. The stitches will dissolve by themselves in 7-10 days. Risks As a result of micro TESE, viable sperm cells may not be obtained. This risk depends on the underlying cause. The chance of finding sperm in a patient with obstruction in the sperm ducts; higher than the patient with hormonal or genetic problems. Postoperatively, infection and bleeding may occur at the operation site.
PGD (Pre-implantation Genetic Diagnostic)
PREIMPLANTATION GENETIC DIAGNOSIS
In recent years, developments in genetics allow genetic analysis to be carried out on embryos developed in vitro by in vitro fertilization ethods and the placement of selected healthy embryos in the uterus of the mother before pregnancy occurs. This method is called pre- regnancy genetic diagnosis (Preimplantation Genetic Diagnosis-PGD).
One of the most important application areas of the PGT technique embryos that do not have a genetic disease but may not have a genetic disorder in their chromosomes.
These disorders are more common in women of advanced age (35 years and older). This situation may result in infertility as it both reduces the chance of attachment of the embryo (implantation) and may cause unwanted abortions. As a matter of fact, 40 out of every 100 pregnancies in women aged 39 and over have problems that occur due to a numerical chromosomal disorder
The aim of PGD is to increase implantation rates, reduce spontaneous abortions and increase healthy baby birth rates by selecting hromosomally normal embryos. Indeed, the miscarriage rate, which can reach up to 23 percent in normal pregnancy due to chromosomal disorders, may decrease to 9 percent after PGD.
Pre-pregnancy genetic diagnosis is performed by taking 1 or 2 cells from embryos developed as a result of fertilization of egg and sperm cells obtained from mother and father candidates in laboratory environment. Special methods called Fluorescence In Situ Hybridization (FISH), Microarray-based comparative genomic hybridization (aCGH) or Polymerase Chain Reaction (PCR) are used for genetic diagnosis. Diagnosis of numerical chromosomal disorders such as monosomy or trisomy (Down syndrome and other trisomies) and single gene diseases (such as hemophilia, Mediterranean anemia, cystic fibrosis, muscular dystrophies) in the baby to be born is possible with PGD. Thus, healthy babies are born by transferring disease-free, healthy embryos to the expectant mother.
DIAGNOSIS BEFORE PREGNANCY
- In couples with a genetic or hereditary disease carrier,
- In couples who have a child or children with a previous genetic disease,
- For the purpose of HLA genotyping (tissue typing),
- In the identification of diseases showing genetic predisposition (tendency)
- Women in the advanced age group (37 years and over) who have been accepted for assisted reproductive techniques,
- In couples with recurrent early pregnancy miscarriages,
- In couples who could not achieve pregnancy with assisted reproductive techniques despite multiple applications or who lost their pregnancy due to miscarriage,
- It is applied in cases of chromosomal disorders or genetic diseases associated with severe male infertility.
HOW IS THE PGT TEST DONE?
- Whether the patient is suitable for PGD is evaluated by the reproductive health specialist, genetic counselor and the doctor of the related disease.
- The couple is prepared for the IVF procedure.
- The egg taken from the mother is fertilized in the laboratory with the sperm taken from the father.
- 1-2 blastomere cells are removed from the obtained embryo by biopsy by embryologists
- Cells obtained by biopsy are prepared and tested according to the method to be applied.
- Embryos with genetic diseases or chromosomal disorders are selected and discarded and healthy embryos are transferred to the mothers womb.
Microchip
In patients with low sperm viability, quantity, number and structural quality, microfluidic technology, also known as the "chip baby method", ensures that the best quality sperm cells are selected by competing with each other in a way similar to the natural environment in the uterus, and ICSI is defined in in vitro fertilization treatment. With the application, it is left into the egg cell by microinjection method.
In this method, sperm cells with the best structural form, genetics and physiology are selected without causing cell damage, since techniques such as centrifugation (settling), vortex (mixing with high vibration) or mixing with a pipette are not applied to the sperm cells, which can physically damage the sperm cells. In classical preparation methods, sperm cells are prepared in a shorter time without being subjected to manipulation by skipping processes such as washing, flotation, gradient (grading), centrifugation (precipitation at high speeds). Thus, the sperm cells with the best DNA quality and physiologically are selected by themselves, and the sperm cells that pass this pre-screening are again screened under the microscope and the sperm cells of excellent quality are used for microinjection.
The above-mentioned classical preparation methods cause sperm cells to undergo respiratory stress, known as oxidative stress, and it has been scientifically proven that this can also cause DNA damage in healthy sperm cells. Better quality embryos are tried to be obtained with sperm cells that have been proven to be of the best quality by scientific data, and thus embryos with the highest potential for implantation (attachment) and development are obtained. The average total mobility in suckling samples taken from male individuals with microchip technology increased by 1.7 times.
The sperm cells obtained by this method were found 3 times faster than the classical preparation methods, and the forward motile sperm cells increased 3.8 times.
Liposuction (Fat Removal)
Liposuction; It is the process of removing fat from the body such as abdomen, hips and neck using the vacuuming technique. Depending on genetic factors and lifestyle, fat may accumulate in different parts of a persons body, even if they are not overweight. Those who have disproportion in the upper and lower areas, fat accumulation in the abdominal area, and a double chin that does not disappear despite losing weight can achieve the look they want with the liposuction method.
Liposuction can also be performed with ultrasound or laser energy. The advantage of these methods, known as Vaser and laser liposuction, is that they break down the fat better, shorten the operation time and reduce the edema that occurs after the operation, helping to achieve an appearance that meets the persons expectations.Abdomen, hips, upper legs, knees, upper arms, under the chin, cheeks and neck are the areas where liposuction method can be applied. This process is a regional shaping method on the body and should not be perceived as a general slimming method. The people most suitable for liposuction are those who can lose weight by applying slimming methods but still have protrusions in some areas.
The duration of surgery depends primarily on the size of the area or areas to be liposuctioned. The operation takes approximately 1 – 1.5 hours. You may need to stay in the hospital on the same day after liposuction performed under local anesthesia, and for 1 day during your surgery under general anesthesia.
WHAT IS THE SPERMIOGRAM TEST FOR ANALYSIS OF SPERM CELL?
Parents who want to have children generally prefer the most common in vitro fertilization treatment. Before this treatment, both mother-to-be and father-to-be go through many tests. Father-to-be passed; The first of the tests to test for infertility or other problems is the sperm test, also known as the spermiogram test. What is the spermiogram test for the analysis of the sperm cell? How is spermiogram done? What do spermiogram test results mean? We will answer all these questions for you in detail below. We recommend that you continue reading our article to have detailed information about the sperm test.
What is a test (spermiogram)?
Sperm test done to men; It is a test to determine sperm health, sperm count, and whether the sperm are moving correctly in the channels. As a result of the sperm test, if the sperm shape is normal and there is a sufficient number of sperm, it is concluded that your reproductive ability is high. However, in some cases, men may have low sperm count or the ability to reproduce despite having abnormal semen. That's why doctors order a second test for the accuracy of the results. If your results are normal in your first sperm test, you give the other test and if it is normal, these two normal tests show that you do not have an infertility problem. If there are different conditions, your doctor may order other tests.
If there is no semen or sperm as a result of the sperm test, this may indicate that your ducts are blocked. If this is the case, your doctor will plan different surgeries to open the channels.
Issues and Precautions to Consider While Giving Sperm Sample
There are important points to be considered before giving the sperm sample and while giving the sperm sample. Among the things to be considered before giving a sperm sample, we can count that "men should abstain from sexual intercourse for 3 days". Fasting for 3 to 5 days is sufficient. These numbers are important because if you fast for less than 3 days, the sperm count may be low as a result of the sperm test. For this reason, we can say that fasting between 3 and 5 days is sufficient. It is possible to list the issues to be considered while giving a sperm sample as follows;
· Storing the sample in a sterile environment: It is important to protect your sample from the outside environment for a healthy and accurate spermiogram test result. If a sterile environment is not provided, the test result may be inaccurate. Therefore, do not put your hands, especially sample containers, etc. It is important that you keep it as sterile as possible.
· Protecting the delivered sperm from heat: Another important point is to keep your sample away from extreme temperature changes after ejaculation. Because these extreme temperature changes negatively affect spermatozoa. Ideal temperatures for the sample cup should be between 20°C and 37°C.
· Sperm volume, amount: Volume is extremely important in the sperm test. Your sperm volume is expected to be at least 1.5 ml. The reason why you cannot reach the lower limit of 1.5 ml may be external discharge during ejaculation. It is important to be careful about this.
· Use of lubricating foreign substances during the sperm test: It is important not to use any lubricant during the sperm test because these substances seriously affect the sperm parameters. External factors with such an impact can lead to wrong conclusions.
How is the Sperm Test Done?
For the sperm test, you must first be at the IVF center or hospital. There are rooms specially prepared for men in hospitals or IVF centers. In these rooms, men give their sperm in a special container. For the effectiveness of the sperm test, the sperm sample is immediately delivered to the laboratory. The sperm sample given in the laboratory is subjected to many processes and the best quality sperms are selected. The purpose of the procedures is to examine the sperm count, motility and shape in the semen and to reach quality sperm as a result.
Apart from the hospital, sperm samples can be placed in a container and brought to the hospital in the home environment. However, this is highly not recommended. Even if this is accepted, the sperm samples should be brought to the hospital and delivered within half an hour.
Issues and Precautions to Consider When Analyzing Sperm Sample
For the sperm test, you must first be at the IVF center or hospital. There are rooms specially prepared for men in hospitals or IVF centers. In these rooms, men give their sperm in a special container. For the effectiveness of the sperm test, the sperm sample is immediately delivered to the laboratory. The sperm sample given in the laboratory is subjected to many processes and the best quality sperms are selected. The purpose of the procedures is to examine the sperm count, motility and shape in the semen and to reach quality sperm as a result.
Apart from the hospital, sperm samples can be placed in a container and brought to the hospital in the home environment. However, this is highly not recommended. Even if this is accepted, the sperm samples should be brought to the hospital and delivered within half an hour.
Issues and Precautions to Consider When Analyzing Sperm Sample
After the sperm test is given by the prospective fathers, it is examined in the laboratory environment. This examination takes approximately 1-2 hours and after the first hour, active results begin to be obtained. However, sometimes different situations can be encountered. For example, the test is given, but no sperm can be seen when looked at. In these cases, sperm are taken again and centrifuged. When faced with such a situation, the time may be extended. If there is no additional test to be done, the test results are immediately available in an average of 1-1.5 hours.
What Do Sperm Test Results Mean?
Sperm test results can be evaluated in many ways. Sperm analysis evaluates the sperm by analyzing it from various aspects. We can list these analyzes as follows:
· Sperm count and density:
Sperm count describes the number of sperm in 1 ml of semen. The World Health Organization advocates that a normal sperm count should be at least 15 million per ml or at least 39 million per sample. Having fewer sperm than these numbers indicates a low sperm count.
· Sperm morphology:
Non-abnormal sperm have a long tail and oval head. Morphology refers to the size and shape of the sperm a person has. Sperm that do not have a normal size or are weak in shape have difficulty reaching the egg and fertilization.
· Sperm motility:
The ability of sperm to move efficiently is one of the most important factors for fertilization.
· PH level of sperm:
When the pH level is too high or too low, it can affect the health of sperm and its ability to pass through the female reproductive tract.
Apart from these, sperm health is examined by looking at many factors such as semen volume, liquefaction, and seminal fructose levels while performing the sperm test. After examining all factors in detail, the results are examined and reported to the patient.
What is the Sperm Test Result of a Healthy Individual?
Low sperm count can have many different causes. The first reason is smoking addiction. Smoking addiction is one of the important factors that reduce the sperm count. In addition to smoking, alcohol and drug addiction also affect sperm count. Sperm count can also be adversely affected when there is a deficiency in hormones, depending on the clogged ducts.
Hormones are one of the important factors for reproduction on their own. Since the deficiency in reproductive hormones directly affects sperm production, it increases the possibility of encountering problems in reproduction. Apart from these, mistakes made by couples who want to have children also affect the sperm count. Using natural products unconsciously and continuing to use them uncontrollably, without knowing the limit, does harm to the person instead of providing benefits. Long-term treatment and drugs used during the treatment also affect the sperm count.
IMSI in Sperm Selection
The IMSI (Intracytoplasmic Morpholgically Selected Sperm Injection) method is the magnification and examination of even the smallest cells using special microscopes. In the past, in the microinjection procedures applied in IVF treatments, living sperm cells could be enlarged up to 400 times. However, with IMSI, sperm can now be enlarged between 6000 and 8000 times. It is possible to examine and detect in detail the disorders called "vacuoles" that indicate the intracellular structures of the sperm and their genetic damage.
The IMSI technique is an extremely useful method. Selected sperm injection; It allows advanced morphological analysis of sperm without damaging the living sperm cell. Sperm with the highest fertilization ability are selected and a high chance of fertilization between 20% and 40% can be obtained with the applied microinjection application.
Precautions to be Considered for Sperm Quality
Couples who want to have children should pay attention to egg and sperm health and be careful in this regard. There are many factors that affect sperm quality, such as those that affect egg quality. One of these factors is undoubtedly a healthy diet. A healthy diet is extremely important for every organ in the body, of course also in sperm health.
In addition, exercise is very important in making you more vigorous and increasing your body's stamina and activity. Regular exercise will make you recover in a short time and will positively affect both your mental and physical health. Alcohol and smoking are substances that affect reproductive cells and should be avoided. This is a proven fact as a result of research. If we gather all these under one title, we can say that one should take care of his own health. Nutrition, avoiding alcohol, smoking, exercising regularly will first affect your health and therefore your sperm quality.
This process, which is sensitive and special for couples who want to have a child, is extremely important for them. In this process, prospective parents experience excitement on the one hand and a lot of stress on the other. Hüma IVF Center, which understands the emotions experienced best and does not spare its support by being by their side throughout the process, is always ready to accompany you.
WHAT IS A REDUCED OVER RESERVE (AMH)?
Ovarian reserve, known as the ovary, is a term used to determine the fertilization ability of the ovary to provide egg cells and to determine the probability of a successful pregnancy. With the advancing age of the expectant mother, the number of egg cells obtained from the follicles for pregnancy decreases. decreased ovarian reserve (AMH); It is a condition in which the ovaries begin to lose their normal production capabilities, reducing fertility. Decreased ovarian reserve reduces women's chances of conceiving spontaneously or with treatment. However, it is aimed to minimize the effects of this situation with various methods. The main causes of decreased ovarian reserve can be listed as follows:
· Smoking,
Chronic diseases,
Coffee consumption
Age of the expectant mother,
Genetic abnormalities (X chromosome abnormalities)
Various treatments (such as radiation for cancer)
· Having undergone ovarian surgery.
You can continue reading our article for reduced ovarian reserve and all its details.
How to Identify Decreased Ovarian Reserve?
Decreased ovarian reserve is determined by examining the hormone tests to be performed on the 2nd or 3rd day of the menstrual period of the expectant mother. FSH hormone gives information about the status of ovarian reserves. If the FSH value is higher than 10, it indicates decreased ovarian capacity.
The best indication of the capacity of the ovaries is the vaginal ultrasound. Existing and developing egg structures can be easily detected here. If there are less than six egg structures in the total ovaries, decreased ovarian reserve may be in question.
In summary, decreased ovarian reserve; It can be understood by clinical evaluation of the person, vaginal ultrasound, measurement of AMH hormone and FSH hormone in the blood.
Can a Woman with a Decreased Ovarian Reserve Get Pregnant?
Existing studies show that women with reduced ovarian reserve can become pregnant both spontaneously and with IVF treatment. Although it has been shown that high serum FSH levels in women are associated with low pregnancy rates, it is not sufficient to make a decision based on this alone. Egg cells also regulate their size under the influence of genetic factors. The speed of the aging process of the ovaries varies greatly among women, except for the age factor. In addition to the successful results of endocrine tests and imaging methods in the numerical evaluation of ovarian reserve, their values in determining the chance of pregnancy remain at a limited level.
The chance of conceiving of a woman who is determined to have decreased ovarian reserve with ovarian reserve tests and clinical evaluations by specialist physicians can be increased by applying appropriate ovulation treatment protocols. Patients with reduced ovarian reserve can become mothers with different techniques today. In order to determine these methods, it is important to plan and apply special treatment methods suitable for patients by considering various factors.
How Is Decreased Ovarian Reserve Treated?
Currently, there is no treatment for decreased ovarian reserve that prevents or slows down ovarian aging. In addition, lifestyle changes have an extremely important role in preventing premature aging of the ovaries and in order to ensure the healthy continuation of egg quality, that is, to increase egg reserve and quality. These;
· Eating a balanced and healthy diet,
Doing regular exercise,
Quality and adequate sleep,
Avoiding chemicals, high glycemic index and fast food style foods,
Not to use substances such as cigarettes and alcohol,
· Using antioxidant drugs under the control of a physician.
If you have decreased ovarian reserve and want to have a child according to your required tests and vaginal ultrasound results, it is extremely important to seek in vitro fertilization treatment in the presence of a specialist doctor, without wasting time.
As Hüma IVF Center, we choose the most appropriate treatment method for you, apply it and continue to serve.
WHAT IS MINI IVF? WHO IS APPLIED? WHAT ARE THE MEDICINES USED IN MINI IVF TREATMENT?
Recently, it has been revealed that egg quality obtained from patients with low reserve is lower and genetic problems in the embryo are higher. In this direction, it is aimed to create fewer but better quality embryos by obtaining higher quality eggs with less drugs. Mini IVF appears as a simplified in vitro fertilization practice, unlike the known in vitro fertilization practices performed with daily injections and high-dose drug use. Especially in patients with a low number of eggs or in advanced age, the success rates are higher than conventional treatments. What is mini IVF, who is it applied to and what are the drugs used in its treatment? You can continue reading our article for questions and all the details.
What is mini IVF?
Mini IVF is an in vitro fertilization application that enables the development of fewer but higher quality eggs by using lower doses of drugs. Eggs developed with this method are taken and fertilization is performed by applying the microinjection technique. Embryos formed after fertilization are transferred to the patient, assuming that the probability of attachment is higher.
In addition to the advantages such as less drug use, less cost and less time spent with mini IVF treatment, high success rates can be obtained in patients with a low number of eggs and advancing age.
Who is mini IVF applied to?
In cases where pregnancy does not occur naturally;
Those who want to use hormone drugs less,
At risk of developing OHSS (overstimulation of the ovaries),
Concerned about the daily injection process in IVF treatment,
Those who have problems in the fallopian tubes and are younger than 35 years old,
Having low egg reserve that cannot be increased with treatment,
Looking for a more economical solution than conventional treatment,
People who have tried many times in vitro fertilization but have not achieved a result, and
Mini IVF treatment can be applied to women who want to reduce the possibility of multiple pregnancy.
However, a treatment plan should be made by a specialist by listening to the patient's history of the disease, analyzing their expectations and performing health checks in detail.
What are the drugs used in mini IVF treatment?
Mini IVF treatment is a type of in vitro fertilization that uses little or no medication to increase and develop the number of eggs. In standard IVF treatments, hormone injections are made for 8-10 days to reproduce eggs, while these drugs are not used in the Mini IVF method. Oral tablets and very low dose hormone injections are used instead. With Mini IVF, which is a natural in vitro fertilization method, it is ensured that the highest quality eggs are produced by using the least amount of medication.
Mini IVF method is aimed to obtain better quality eggs with the use of low doses of drugs. At this point, it is possible to determine your treatment plan by consulting your doctor. You can visit our website for more information.
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WHAT IS COMPREHENSIVE CHROMOSOME SCREENING (NGS)?
IVF treatments are supported by a wide range of tests and analyzes to get a healthy result. With the help of these tests, problems that may occur before and after pregnancy are also detected and planning is carried out in this direction. NGS, a genetic analysis technology that allows comprehensive chromosome screening to be performed in embryos, is a test that gives extremely effective results as technological developments gain momentum. With NGS, embryos are scanned quickly and effectively, and genetic problems at the chromosome level are detected before pregnancy. The aim of this method is to select a healthy embryo by performing genetic analysis on embryos before the transfer process and to increase the chances of a healthy pregnancy. You can continue reading our article for the details of the NGS test.
What is Comprehensive Chromosome Screening (NGS)?
It is extremely important that the embryos obtained in IVF treatments are successfully transferred to the uterus. But in some cases, pregnancy may not be achieved. One of the most important reasons why a healthy pregnancy cannot be achieved despite embryo transfer in treatment has been identified as chromosome disorders that occur in embryos. In order to achieve a healthy and successful result in IVF treatments, it is necessary to analyze the embryos in detail and detect chromosomal abnormalities. Previously, the multidimensional and complex structure of chromosomes would have made multiple tests necessary. While this situation is quite time consuming and costly, the NGS (Next Generation Sequencing) test appears as a result of the developing technology today. The NGS method is a newly developed genetic analysis technology that allows comprehensive chromosome screening of embryos. The NGS method allows all embryos to be screened within a short period of time. With NGS, which offers a quick and detailed scan, chromosome-related problems are diagnosed before pregnancy. All 24 chromosomes are scanned with the NGS test.
Comprehensive chromosomal screening practices performed by the NGS method play an extremely important role in diagnosing disorders and have an effect on facilitating healthy outcomes in IVF treatments.
What are the Features of the NGS Technique?
Chromosomal abnormalities are determined by screening with the NGS method. Embryos containing more than two or more cell communities with different chromosomal structures are called “mosaic embryos”. Mosaic embryos are detected more easily with the NGS technique. After these chromosomal abnormalities detected by the NGS test are detected accurately and in detail, the process is advanced by including them in the treatment planning. Compared to the different PGD methods used to date and known, the NGS method provides a high-intensity scanning area, allowing you to detect even some genetic disorders, as well as numerical changes occurring in chromosomes.
What Genetic Defects Can Be Detected with NGS-Based PGS?
Embryos obtained in IVF treatment are evaluated according to various criteria in terms of the characteristics they have, and a healthy result is sought by ensuring the transfer of the embryo with the best developmental characteristics to the uterus. Examination of the developmental characteristics of the embryo under a microscope by classical methods does not give a clear information about the chromosomal state of the embryo. This information is only reached by performing a genetic screening with PGS. Even if the embryos have a good quality structure, they can contain various chromosomal problems, and this can also lead to problems such as early miscarriages, some structural disorders in the developing fetus, or the embryo does not hold on to the uterus. The main purpose of using the PGS method, which is an NGS-based method, is to increase the adhesion of the embryo to the uterus, which is found to have a chromosomally normal structure, to reduce the likelihood of miscarriage that may occur later, and as a result, to increase the likelihood of couples having healthy babies. The NGS-based PGS operation is performed by embryologists who have the necessary education and experience in this regard. The process takes a short time and does not cause any harm to the embryo. The PGS process begins by combining the egg taken from the expectant mother and the sperm taken from the expectant father outside the body. 5. Development of embryos from formed embryos. or 6. on the day when the blastocyst is at the stage, several cells are taken by biopsy without damaging the embryo. These received cells are sent to the genetic laboratory for a scan of 24 chromosomes, while the embryos are frozen. At this point, it is extremely important that the procedure is performed by a qualified embryologist so that the embryo does not get damaged. At the end of this examination, the embryo or embryos whose genetic structure has been determined to be healthy are transferred after completion of intrauterine preparation and pregnancy results that reach higher rates are obtained, especially.
To summarize briefly; NGS-based PGS is a genetic screening method and can be used to detect numerical and structural imbalances in chromosomes. However, single gene diseases, especially those with familial transmission, cannot be detected with the PGS method.
Who are the Groups of Patients Who Can Be Administered NGS?
The benefits of the NGS method, which is a new generation genetic analysis technology, also raises the question of which patient groups this technique can be applied to. Before answering this question, we can state that the intended point of the NGS method is to be able to detect numerical and structural changes in chromosomes. Therefore, we can address the question of which people have these changes more often for groups of patients who can be administered NGS. Groups of patients for whom NGS can be applied can be listed as follows;
· In cases of repeated miscarriage,
· in expectant mothers over the age of 38,
· In severe male infertility,
* In cases of infertility, the cause of which is unknown,
· It is applied in cycles of continuous self-recurring treatment failures.
The NGS method, which is a rapidly developing field, is actively used in many countries today due to its possibilities and facilitating and accelerating effects for the process.
What are the Advantages of Preimplantastone Genetic Screening with NGS?
NGS, a new genetic examination method used to screen for 24 chromosomes in embryos, provides the opportunity to examine and sequence the entire human genome both numerically and structurally in a short period of time, such as a single day. It offers us a revolutionary technology in this aspect. The improved NGS method can detect mosaic embryos better than other PGD methods. The main advantages of Preimplantastone Genetic Screening with NGS are that it allows you to quickly scan a large area of genes, both numerically and structurally. In addition to scanning gene fields numerically and structurally, the NGS method also has advantages such as obtaining a more accurate result with a low margin of error, achieving faster results, and having a lower cost. With this method, 24 chromosome screening can also be performed simultaneously with the study of single gene diseases and HLA typing.
Does NGS Damage the Embryo?
IVF treatments are an extremely exciting period for couples. During this period, in order to obtain a healthy result, various tests are applied to the embryos obtained to determine the success rate. In some cases, couples may have a high risk of genetically abnormal embryo development. Advanced maternal age is one of these conditions. Embryos that are not genetically normal are not suitable for transfer. In order to be able to determine the chromosomal status of embryos and to obtain a healthy result, process planning is carried out in the light of the NGS result. Another confusing situation for couples at this point is whether NGS causes any damage to the embryo during the application phase. Doctors who specialize in their field and NGS performed under appropriate conditions do not pose a danger risk to the embryo. At this point, managing and planning the process in accordance with the needs with a reliable specialist and institution will also be an extremely important step.
Does Pregnancy Always Occur With a Smoothly Detected Embryo?
After the tests and examinations, embryos that do not carry any genetic abnormalities are placed in the uterus. The probability of the occurrence of pregnancy after this procedure develops due to various factors. These factors;
· Women's age
· The amount of ovarian reserve of the woman
* Sperm quality
· Embryo quality
· Ensuring a proper intrauterine environment
· The presence of hydrosalpinx
· Conditions encountered during embryo transfer
it can be sorted as follows. All these factors are among the dec that affect the occurrence of pregnancy. From this point of view, it is impossible to say that pregnancy always occurs with an embryo that is detected without problems.
Studies have shown that age-related embryos are less likely to be chromosomally normal. For this reason, pregnancy rates are also decreasing due to the increasing age of women, especially in IVF trials that have not been applied to PGS. In women under the age of forty, NGS-based PGS normal embryos vary between 40 and 60 percent probability with the results of the analysis, the rate falls below twenty percent in people over the age of 40.
In women over the age of forty, a low pregnancy rate is achieved by transferring an embryo that has not been genetically screened with NGS, while this rate is increased by transferring an embryo that has been diagnosed with NGS and is chromosomally normal.
How Many Days Do NGS Results Come Out?
The embryos that have been biopsied are 5 or 6 until they reach the blastocyst stage. by following it up to the day, only embryos that have not been detected as abnormalities are transferred to the expectant mother's uterus (uterus). The NGS process applied to the embryos is completed within the same day. In this way, treatment planning is quickly directed.
What are the NGS Test Prices?
The information obtained from the results of the NGS test gives a comprehensive information for the IVF process. At this point, NGS, a new generation genetic screening test, has entered our lives as a result of high technology. It is a method that also has many advantages, especially if it provides a quick and wide information about the chromosomal state of the embryo. In addition to the advantages it provides, NGS is a method that also has an extremely low cost. This is a situation that also increases the availability of the test. As the Huma IVF family, we continue to be there for our couples during this exciting process. For all your questions about NGS, you can review our site and contact us for detailed information.
In this article, we have included details about the NGS method. It is important to detect embryos that do not have chromosomal abnormalities, as well as to successfully transfer the embryos obtained in IVF treatments to the uterus. Comprehensive chromosomal screening practices performed by the NGS method play an extremely effective role in detecting chromosomal disorders in embryos and increase the risk of a positive outcome of the process.
Cheek Implants (Malar Augmentation): Enhancing Facial Contours for a Youthful Look
Cheek Implants (Malar Augmentation): Enhancing Facial Contours for a Youthful Look
Introduction
Cheek implants, also known as malar augmentation, are a cosmetic surgical procedure designed to enhance the shape and definition of the cheeks. This procedure is ideal for individuals who have flat or sunken cheeks due to aging, genetics, or weight loss. By adding volume to the midface, cheek implants create a more youthful and balanced appearance.
Why Consider Cheek Implants?
The structure of the face changes over time due to aging, loss of collagen, and fat redistribution. These changes can lead to a sunken or hollow look in the midface region. Some people naturally have less prominent cheekbones, making their facial features appear less defined. Cheek implants offer a long-lasting solution to enhance facial contours and restore lost volume.
Types of Cheek Implants
There are different types of cheek implants, each designed to address specific concerns:
Malar Implants: Placed directly on the cheekbones to create more definition and prominence.
Submalar Implants: Positioned below the cheekbones to restore volume to the midface and improve a hollow appearance.
Combined Implants: A combination of both malar and submalar implants for a more comprehensive enhancement.
The Procedure
Cheek augmentation with implants is typically performed under general anesthesia or local anesthesia with sedation. The surgeon makes small incisions inside the mouth (intraoral approach) or along the lower eyelid (transcutaneous approach) to insert the implants. The implants, made from biocompatible materials such as silicone or porous polyethylene, are carefully positioned and secured to achieve the desired shape.
The procedure generally takes about one to two hours, depending on the complexity. Once the implants are placed, the incisions are closed with dissolvable stitches.
Recovery and Aftercare
Following the procedure, patients can expect some swelling, bruising, and mild discomfort for the first few days. Most individuals can return to work within a week, but full recovery may take several weeks. Postoperative care includes:
Keeping the head elevated to minimize swelling
Avoiding strenuous activities for at least two weeks
Following the surgeon’s dietary and hygiene instructions if the incision was made inside the mouth
Attending follow-up appointments to monitor healing
Benefits of Cheek Implants
Long-Lasting Results: Unlike dermal fillers, which require regular maintenance, cheek implants provide a permanent solution.
Natural-Looking Enhancement: Well-placed implants can create a naturally contoured face.
Customizable Options: Various sizes and shapes are available to meet individual aesthetic goals.
Minimally Visible Scars: With incisions made inside the mouth or discreetly along the lower eyelid, scarring is minimal.
Potential Risks and Considerations
As with any surgical procedure, cheek augmentation carries some risks, including:
Infection
Implant displacement
Nerve damage leading to temporary numbness
Asymmetry
Prolonged swelling
Choosing an experienced and board-certified surgeon significantly reduces these risks and ensures optimal results.
Alternatives to Cheek Implants
For those who want to enhance their cheeks without surgery, non-invasive alternatives include:
Dermal Fillers: Hyaluronic acid or calcium hydroxylapatite-based fillers can add volume temporarily.
Fat Grafting: A natural alternative using the patient’s own fat harvested from another area of the body.
Thread Lifts: A minimally invasive procedure that lifts and contours the cheeks with dissolvable threads.
Who is an Ideal Candidate?
The best candidates for cheek implants are individuals who:
Desire permanent cheek enhancement
Have a weak or flat midface structure
Are in good overall health
Have realistic expectations about the results
Conclusion
Cheek implants are a highly effective way to achieve a defined and youthful facial structure. Whether to restore lost volume or enhance natural contours, malar augmentation provides a permanent solution for a well-proportioned and aesthetically pleasing look. Consultation with a qualified plastic surgeon is essential to determine the best approach for achieving your aesthetic goals.
