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IVF treatment; It is the method that offers the highest chance of pregnancy for couples who want to have a baby but cannot conceive naturally. In vitro fertilization method can be applied as a result of unprotected intercourse for more than 1 year, when pregnancy does not occur. Although it is a successful method, it may not always be possible to achieve 100% success in IVF treatments. There are many factors that determine the probability of successful IVF treatment. 

What Factors Depends on Success in IVF Treatment?

In IVF treatment, it is aimed to catch pregnancy in the first time, but pregnancy is not possible for every woman at once. Factors affecting the success of IVF treatment include the age of the expectant mother, weight status, problems in the uterus, hydrosalpinx in the tubes, immune system problems, smoking degree, alcohol use rate, and decreased ovarian reserve. With this; Various male-related conditions such as sperm immobility, severe deformities, and absence of sperm in the semen also affect the success rate of IVF treatment. General statistical data can give you information about the success rate in IVF treatment, but it should not be forgotten that every couple is very special and unique. In IVF treatment, your doctor can better determine your individual chances, taking into account your personalized factors. 

What are the Risks of IVF Treatment?

As with any treatment, there are some risks in IVF treatment. However, some of these risks, which are likely to be encountered in IVF treatment, are predictable and can be intervened early, although these risks are very rare. We can list these risks as follows: Mild bruising, swelling and pain may occur in the areas where the drugs were injected. Overstimulation of the eggs can result in weight gain, nausea, vomiting and bloating. There may be a risk of ectopic pregnancy. Bleeding may occur during egg collection.

What Should Be Done After Unsuccessful IVF?

 Failure of one or more IVF attempts can be extremely challenging, disappointing couples. This situation is extremely natural. One of the most important reasons for a failed IVF treatment is poor embryo quality. Defective and damaged embryos cannot be attached to the uterus after they are transferred to the uterus. However, in some cases, pregnancy may not be achieved despite transferring good quality embryos. Your doctor will evaluate the reasons for the failure of your IVF process in detail to determine what the problem is. These points will be taken into account in future attempts after the problem is determined. Taking a break for at least a month after a failed IVF attempt will also be very beneficial for the process. As developments in the field of medicine increase, it becomes easier to detect and eliminate negative situations. It is important that couples who fail their first IVF attempt should not despair. When conditions are improved, the chances of pregnancy will be higher in subsequent attempts.

As couples who want to become parents cannot become parents with natural methods, couples resort to some treatments. In vitro fertilization is the first treatment method. And IVF treatment is a very advanced and effective treatment method. Some applications in IVF treatment are important for the positive outcome of the treatment. Embryo glue application, which is one of the important application methods, is a very successful application. Embryo glue is one of the applications without any known risk. As a result of the studies, it was concluded that it did not increase the risk of miscarriage or pregnancy complications. Now we will provide you with detailed information about embryo glue. We wish you pleasant reading.

What is Embryo Adhesive?

Embryo glue, a method used in IVF treatments, is a kind of liquid embryo culture medium enriched with a substance called hyaluronan, in which embryos are left before transfer to the uterus of the expectant mother.

Hyaluronan is a natural carbohydrate found in all tissues in the body. The embryo needs an environment rich in carbohydrates, amino acids and protein in order to develop healthily inside. In addition, embryo glue is also called embryo glue because it reduces the ability of the embryo to move in the uterus.

How and Who Is Embryo Adhesive Used?

Embryo adhesive application is done as follows:

After the embryos are developed in the laboratory for 3-5 days, the most suitable one for embryo transfer is selected.

· The most suitable embryos selected for transfer are taken into the embryo glue.

· Embryos are kept in this environment for about 30 minutes.

· After standing, the embryos are taken from the culture dish and drawn into the catheter (a thin tube).

· The catheter is then passed through the cervix under ultrasound guidance and the embryos are transferred to the uterus.

In expectant mothers who have repeated in vitro fertilization failure using the embryo glue method,

It is used in couples who want to have children over the age of 35, when the quality of the embryo depending on the egg or sperm is not very good.

Is the Success Rate High in Embryo Bonding?

Embryo adhesive is one of the most frequently used applications for the last 10 years in order to increase the chance of success in IVF treatment. Experts were unsure about the effectiveness of embryo glue at first. However, in recent years, the effectiveness of embryo glue has been observed as a result of scientific research. Today, embryo glue is applied by various IVF centers. Hüma IVF Center is one of these centers.

The high concentration of hyaluronan concentrates the embryo glue similar to the tissue of the fluids in the womb, so that better mixing of these fluids minimizes the mobility of the embryo. In addition, hyaluronan acts as a bridge between the embryo and the inner wall of the uterus by binding to the inner wall of the uterus and the molecules on the surface of the embryo. In this way, it helps the embryo to attach to the uterus.

We aimed to give you information on this subject by considering the embryo glue method. We talked about how this method is applied and its success rate.

IVF treatment, which is one of the methods of treatment that helps reproduction, begins with the collection of eggs from the expectant mother and the removal of sperm cells from the expectant father. The embryo, which appeared after the fertilization was carried out in the laboratory environment, is placed in the womb of the expectant mother. From this point on, pregnancy continues like a pregnancy acquired by natural means.

When should couples who cannot have children turn to IVF treatment?

A woman under the age of 35 who does not have any diseases that can prevent her from becoming pregnant should definitely be examined if she cannot conceive despite having unprotected and regular sexual intercourse for 1 year and seek treatment if deemed necessary. Women who are over the age of 35 or who have previously had any problems affecting conception should only try for 6 months.

How is IVF Performed? What are the Necessary Conditions?

In vitro fertilization can be defined as the process of placing the healthiest embryo in the womb obtained as a result of fertilization of eggs collected from the expectant mother with the sperm of the expectant father in the laboratory environment. Before starting IVF treatment, the reproductive abilities of both a man and a woman are evaluated. Then hormone therapy is started to allow the expectant mother's eggs to enter the maturation process. Then, a cracking needle is made and the eggs are released from the follicles. During the egg collection process, the ripening eggs of the expectant mother are collected with the help of transvaginal ultrasound. At this time, sperm cells are taken from the expectant father. 

Fertilization is achieved by means of reproductive cells that are brought together in a laboratory environment dec The healthiest of the embryos that occur, or in other words, the best IVF, is transferred to the expectant mother's uterus accompanied by ultrasound. After about half an hour after this procedure, the couple is sent home. In some cases, more than one embryo needs to be transferred to the mother's womb.

Blastocyst transfer, which is one of the advanced in vitro fertilization techniques applied today, is a method that offers a much higher chance of pregnancy to couples who want to have children. The blastocyst transfer method, which is a method that minimizes the possibility of multiple pregnancy, which is frequently encountered in IVF treatments, supports families in making their plans to have a child more effectively. The blastocyst is defined as the 5th or 6th day of the egg becoming an embryo. Before transfer, one or two embryos of the highest quality are selected and the transfer is carried out. This method is among the most important processes of IVF treatment. What is blastocyst transfer, what are its advantages and risks? You can continue reading our article, which includes the details of blastocyst transfer with questions.

What is blastocyst transfer?

Blastocyst transfer, which has an extremely important place in the IVF treatment process, is the process of transferring the embryo created in the laboratory environment to the woman on the 5th or 6th development day. Embryos are followed in incubators in the laboratory and when they reach the blastocyst stage, transfer to the uterus is performed. Blastocyst transfer has many positive contributions to the IVF process, such as enabling better quality embryo transfer and reducing the risk of multiple pregnancy.

What are the advantages of blastocyst transfer?

Blastocyst transfer is a method that has been used frequently in recent years, depending on the developing technologies. In the first years of in vitro fertilization treatment, the expected time for transfer was 48 hours, but this period has been extended in parallel with the developments experienced today. In the blastocyst transfer method, embryos with the highest success rate are selected more easily with transfers made after 5 and 6 days. In general, the advantages of blastocyst transfer can be listed as follows;

The chance to achieve better results against recurrent pregnancy failures, thanks to the selection of embryos with better development potential and compatibility with the uterus,

Reducing the possibility of multiple pregnancy by transferring fewer embryos with high viability,

The chance to observe the embryo development more clearly and healthily,

Freezing of embryos at the time when they have the highest developmental power, that is, at the blastocyst stage,

· Allowing different methods to examine embryo viability.

What is the risk of blastocyst transfer?

The condition that can be encountered frequently as a result of blastocyst transfer is the factor of multiple pregnancy. For this reason, some legal restrictions have been imposed on the number of embryos to be transferred in order to be protected from the risks of multiple pregnancy. For our country, this limit has been determined to be a maximum of 2 embryos. By performing 1 or 2 blastocyst transfers in embryo transfer on the 5th day, both the risk of multiple pregnancy is reduced and the chance of pregnancy is increased. The aim of IVF treatment is to achieve a healthy fertilization. In this direction, better quality but less number of embryo transfers will minimize the risks that may be encountered and will facilitate healthy results.

Who is blastocyst transfer suitable for?

Blastocyst transfer can be applied to all couples with a high number of fertilized eggs and good embryo quality on the 2nd day. Since a single embryo can be transferred in the first two attempts under the age of 35, a blastocyst transfer will be made to them, thus preventing multiple pregnancy. In our country, blastocyst transfer is successfully applied and high success rates are achieved. However, the remaining quality embryos after the transfer are successfully frozen with the vitrification method, which is a new and fast freezing technique, giving couples a second chance. You can visit our website for more information and to make an appointment.

Recently, it has been revealed that egg quality obtained from patients with low reserve is lower and genetic problems in the embryo are higher. In this direction, it is aimed to create fewer but better quality embryos by obtaining higher quality eggs with less drugs. Mini IVF appears as a simplified in vitro fertilization practice, unlike the known in vitro fertilization practices performed with daily injections and high-dose drug use. Especially in patients with a low number of eggs or in advanced age, the success rates are higher than conventional treatments. What is mini IVF, who is it applied to and what are the drugs used in its treatment? You can continue reading our article for questions and all the details.

What is mini IVF?

Mini IVF is an in vitro fertilization application that enables the development of fewer but higher quality eggs by using lower doses of drugs. Eggs developed with this method are taken and fertilization is performed by applying the microinjection technique. Embryos formed after fertilization are transferred to the patient, assuming that the probability of attachment is higher.

In addition to the advantages such as less drug use, less cost and less time spent with mini IVF treatment, high success rates can be obtained in patients with a low number of eggs and advancing age.

Who is mini IVF applied to?

In cases where pregnancy does not occur naturally;

Those who want to use hormone drugs less,

At risk of developing OHSS (overstimulation of the ovaries),

Concerned about the daily injection process in IVF treatment,

Those who have problems in the fallopian tubes and are younger than 35 years old,

Having low egg reserve that cannot be increased with treatment,

Looking for a more economical solution than conventional treatment,

People who have tried many times in vitro fertilization but have not achieved a result, and

Mini IVF treatment can be applied to women who want to reduce the possibility of multiple pregnancy.

However, a treatment plan should be made by a specialist by listening to the patient's history of the disease, analyzing their expectations and performing health checks in detail.

What are the drugs used in mini IVF treatment?

Mini IVF treatment is a type of in vitro fertilization that uses little or no medication to increase and develop the number of eggs. In standard IVF treatments, hormone injections are made for 8-10 days to reproduce eggs, while these drugs are not used in the Mini IVF method. Oral tablets and very low dose hormone injections are used instead. With Mini IVF, which is a natural in vitro fertilization method, it is ensured that the highest quality eggs are produced by using the least amount of medication.

Mini IVF method is aimed to obtain better quality eggs with the use of low doses of drugs. At this point, it is possible to determine your treatment plan by consulting your doctor. You can visit our website for more information.

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IVF treatments are supported by a wide range of tests and analyzes to get a healthy result. With the help of these tests, problems that may occur before and after pregnancy are also detected and planning is carried out in this direction. NGS, a genetic analysis technology that allows comprehensive chromosome screening to be performed in embryos, is a test that gives extremely effective results as technological developments gain momentum. With NGS, embryos are scanned quickly and effectively, and genetic problems at the chromosome level are detected before pregnancy. The aim of this method is to select a healthy embryo by performing genetic analysis on embryos before the transfer process and to increase the chances of a healthy pregnancy. You can continue reading our article for the details of the NGS test.

What is Comprehensive Chromosome Screening (NGS)?

It is extremely important that the embryos obtained in IVF treatments are successfully transferred to the uterus. But in some cases, pregnancy may not be achieved. One of the most important reasons why a healthy pregnancy cannot be achieved despite embryo transfer in treatment has been identified as chromosome disorders that occur in embryos. In order to achieve a healthy and successful result in IVF treatments, it is necessary to analyze the embryos in detail and detect chromosomal abnormalities. Previously, the multidimensional and complex structure of chromosomes would have made multiple tests necessary. While this situation is quite time consuming and costly, the NGS (Next Generation Sequencing) test appears as a result of the developing technology today. The NGS method is a newly developed genetic analysis technology that allows comprehensive chromosome screening of embryos. The NGS method allows all embryos to be screened within a short period of time. With NGS, which offers a quick and detailed scan, chromosome-related problems are diagnosed before pregnancy. All 24 chromosomes are scanned with the NGS test.

Comprehensive chromosomal screening practices performed by the NGS method play an extremely important role in diagnosing disorders and have an effect on facilitating healthy outcomes in IVF treatments.

What are the Features of the NGS Technique?

Chromosomal abnormalities are determined by screening with the NGS method. Embryos containing more than two or more cell communities with different chromosomal structures are called “mosaic embryos”. Mosaic embryos are detected more easily with the NGS technique. After these chromosomal abnormalities detected by the NGS test are detected accurately and in detail, the process is advanced by including them in the treatment planning. Compared to the different PGD methods used to date and known, the NGS method provides a high-intensity scanning area, allowing you to detect even some genetic disorders, as well as numerical changes occurring in chromosomes.

What Genetic Defects Can Be Detected with NGS-Based PGS?

Embryos obtained in IVF treatment are evaluated according to various criteria in terms of the characteristics they have, and a healthy result is sought by ensuring the transfer of the embryo with the best developmental characteristics to the uterus. Examination of the developmental characteristics of the embryo under a microscope by classical methods does not give a clear information about the chromosomal state of the embryo. This information is only reached by performing a genetic screening with PGS. Even if the embryos have a good quality structure, they can contain various chromosomal problems, and this can also lead to problems such as early miscarriages, some structural disorders in the developing fetus, or the embryo does not hold on to the uterus. The main purpose of using the PGS method, which is an NGS-based method, is to increase the adhesion of the embryo to the uterus, which is found to have a chromosomally normal structure, to reduce the likelihood of miscarriage that may occur later, and as a result, to increase the likelihood of couples having healthy babies. The NGS-based PGS operation is performed by embryologists who have the necessary education and experience in this regard. The process takes a short time and does not cause any harm to the embryo. The PGS process begins by combining the egg taken from the expectant mother and the sperm taken from the expectant father outside the body. 5. Development of embryos from formed embryos. or 6. on the day when the blastocyst is at the stage, several cells are taken by biopsy without damaging the embryo. These received cells are sent to the genetic laboratory for a scan of 24 chromosomes, while the embryos are frozen. At this point, it is extremely important that the procedure is performed by a qualified embryologist so that the embryo does not get damaged. At the end of this examination, the embryo or embryos whose genetic structure has been determined to be healthy are transferred after completion of intrauterine preparation and pregnancy results that reach higher rates are obtained, especially.

To summarize briefly; NGS-based PGS is a genetic screening method and can be used to detect numerical and structural imbalances in chromosomes. However, single gene diseases, especially those with familial transmission, cannot be detected with the PGS method.

Who are the Groups of Patients Who Can Be Administered NGS?

The benefits of the NGS method, which is a new generation genetic analysis technology, also raises the question of which patient groups this technique can be applied to. Before answering this question, we can state that the intended point of the NGS method is to be able to detect numerical and structural changes in chromosomes. Therefore, we can address the question of which people have these changes more often for groups of patients who can be administered NGS. Groups of patients for whom NGS can be applied can be listed as follows;

· In cases of repeated miscarriage,

· in expectant mothers over the age of 38,

· In severe male infertility,

* In cases of infertility, the cause of which is unknown,

· It is applied in cycles of continuous self-recurring treatment failures.

The NGS method, which is a rapidly developing field, is actively used in many countries today due to its possibilities and facilitating and accelerating effects for the process.

What are the Advantages of Preimplantastone Genetic Screening with NGS?

NGS, a new genetic examination method used to screen for 24 chromosomes in embryos, provides the opportunity to examine and sequence the entire human genome both numerically and structurally in a short period of time, such as a single day. It offers us a revolutionary technology in this aspect. The improved NGS method can detect mosaic embryos better than other PGD methods. The main advantages of Preimplantastone Genetic Screening with NGS are that it allows you to quickly scan a large area of genes, both numerically and structurally. In addition to scanning gene fields numerically and structurally, the NGS method also has advantages such as obtaining a more accurate result with a low margin of error, achieving faster results, and having a lower cost. With this method, 24 chromosome screening can also be performed simultaneously with the study of single gene diseases and HLA typing.

Does NGS Damage the Embryo?

IVF treatments are an extremely exciting period for couples. During this period, in order to obtain a healthy result, various tests are applied to the embryos obtained to determine the success rate. In some cases, couples may have a high risk of genetically abnormal embryo development. Advanced maternal age is one of these conditions. Embryos that are not genetically normal are not suitable for transfer. In order to be able to determine the chromosomal status of embryos and to obtain a healthy result, process planning is carried out in the light of the NGS result. Another confusing situation for couples at this point is whether NGS causes any damage to the embryo during the application phase. Doctors who specialize in their field and NGS performed under appropriate conditions do not pose a danger risk to the embryo. At this point, managing and planning the process in accordance with the needs with a reliable specialist and institution will also be an extremely important step.

Does Pregnancy Always Occur With a Smoothly Detected Embryo?

After the tests and examinations, embryos that do not carry any genetic abnormalities are placed in the uterus. The probability of the occurrence of pregnancy after this procedure develops due to various factors. These factors;

· Women's age

· The amount of ovarian reserve of the woman

* Sperm quality

· Embryo quality

· Ensuring a proper intrauterine environment

· The presence of hydrosalpinx

· Conditions encountered during embryo transfer

it can be sorted as follows. All these factors are among the dec that affect the occurrence of pregnancy. From this point of view, it is impossible to say that pregnancy always occurs with an embryo that is detected without problems.

Studies have shown that age-related embryos are less likely to be chromosomally normal. For this reason, pregnancy rates are also decreasing due to the increasing age of women, especially in IVF trials that have not been applied to PGS. In women under the age of forty, NGS-based PGS normal embryos vary between 40 and 60 percent probability with the results of the analysis, the rate falls below twenty percent in people over the age of 40.

In women over the age of forty, a low pregnancy rate is achieved by transferring an embryo that has not been genetically screened with NGS, while this rate is increased by transferring an embryo that has been diagnosed with NGS and is chromosomally normal.

How Many Days Do NGS Results Come Out?

The embryos that have been biopsied are 5 or 6 until they reach the blastocyst stage. by following it up to the day, only embryos that have not been detected as abnormalities are transferred to the expectant mother's uterus (uterus). The NGS process applied to the embryos is completed within the same day. In this way, treatment planning is quickly directed.

What are the NGS Test Prices?

The information obtained from the results of the NGS test gives a comprehensive information for the IVF process. At this point, NGS, a new generation genetic screening test, has entered our lives as a result of high technology. It is a method that also has many advantages, especially if it provides a quick and wide information about the chromosomal state of the embryo. In addition to the advantages it provides, NGS is a method that also has an extremely low cost. This is a situation that also increases the availability of the test. As the Huma IVF family, we continue to be there for our couples during this exciting process. For all your questions about NGS, you can review our site and contact us for detailed information.

In this article, we have included details about the NGS method. It is important to detect embryos that do not have chromosomal abnormalities, as well as to successfully transfer the embryos obtained in IVF treatments to the uterus. Comprehensive chromosomal screening practices performed by the NGS method play an extremely effective role in detecting chromosomal disorders in embryos and increase the risk of a positive outcome of the process.